Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis

Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis

Bone loss is common in patients with diabetes, but the underlying molecular and cellular mechanisms are unclear. Here the authors show high succinate levels in mice with type 2 diabetes and that succinate can signal through succinate receptor 1 on osteoclasts to induce bone resorption.

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Autores principales: Yuqi Guo, Chengzhi Xie, Xiyan Li, Jian Yang, Tao Yu, Ruohan Zhang, Tianqing Zhang, Deepak Saxena, Michael Snyder, Yingjie Wu, Xin Li
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Science
Q
Acceso en línea:https://doaj.org/article/107d67f077f641adbe8dbcbec6310835
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spelling oai:doaj.org-article:107d67f077f641adbe8dbcbec63108352021-12-02T14:42:06ZSuccinate and its G-protein-coupled receptor stimulates osteoclastogenesis10.1038/ncomms156212041-1723https://doaj.org/article/107d67f077f641adbe8dbcbec63108352017-05-01T00:00:00Zhttps://doi.org/10.1038/ncomms15621https://doaj.org/toc/2041-1723Bone loss is common in patients with diabetes, but the underlying molecular and cellular mechanisms are unclear. Here the authors show high succinate levels in mice with type 2 diabetes and that succinate can signal through succinate receptor 1 on osteoclasts to induce bone resorption.Yuqi GuoChengzhi XieXiyan LiJian YangTao YuRuohan ZhangTianqing ZhangDeepak SaxenaMichael SnyderYingjie WuXin LiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution DOAJ
collection DOAJ
language EN
topic Science
Q
spellingShingle Science
Q
Yuqi Guo
Chengzhi Xie
Xiyan Li
Jian Yang
Tao Yu
Ruohan Zhang
Tianqing Zhang
Deepak Saxena
Michael Snyder
Yingjie Wu
Xin Li
Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
description Bone loss is common in patients with diabetes, but the underlying molecular and cellular mechanisms are unclear. Here the authors show high succinate levels in mice with type 2 diabetes and that succinate can signal through succinate receptor 1 on osteoclasts to induce bone resorption.
format article
author Yuqi Guo
Chengzhi Xie
Xiyan Li
Jian Yang
Tao Yu
Ruohan Zhang
Tianqing Zhang
Deepak Saxena
Michael Snyder
Yingjie Wu
Xin Li
author_facet Yuqi Guo
Chengzhi Xie
Xiyan Li
Jian Yang
Tao Yu
Ruohan Zhang
Tianqing Zhang
Deepak Saxena
Michael Snyder
Yingjie Wu
Xin Li
author_sort Yuqi Guo
title Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
title_short Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
title_full Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
title_fullStr Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
title_full_unstemmed Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis
title_sort succinate and its g-protein-coupled receptor stimulates osteoclastogenesis
publisher Nature Portfolio
publishDate 2017
url https://doaj.org/article/107d67f077f641adbe8dbcbec6310835
work_keys_str_mv AT yuqiguo succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT chengzhixie succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT xiyanli succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT jianyang succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT taoyu succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT ruohanzhang succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT tianqingzhang succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT deepaksaxena succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT michaelsnyder succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT yingjiewu succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
AT xinli succinateanditsgproteincoupledreceptorstimulatesosteoclastogenesis
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