Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

Dian-Jeng Li,1,2 Kuan-Shang Chung,1 Hung-Chi Wu,1 Chih-Yao Hsu,1 Cheng-Fang Yen2,3 1Department of Addiction Science, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan; 2Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Departm...

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Autores principales:	Li DJ, Chung KS, Wu HC, Hsu CY, Yen CF
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Methadone new-onset sleep disturbance heroin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/1083f4b732764f45ba4daacddd8dfa4b
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spelling	oai:doaj.org-article:1083f4b732764f45ba4daacddd8dfa4b2021-12-02T02:19:36ZPredictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan1178-2021https://doaj.org/article/1083f4b732764f45ba4daacddd8dfa4b2018-10-01T00:00:00Zhttps://www.dovepress.com/predictors-of-sleep-disturbance-in-heroin-users-receiving-methadone-ma-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Dian-Jeng Li,1,2 Kuan-Shang Chung,1 Hung-Chi Wu,1 Chih-Yao Hsu,1 Cheng-Fang Yen2,3 1Department of Addiction Science, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan; 2Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Introduction: Sleep disturbance is a major health concern for heroin users receiving methadone maintenance treatment (MMT). The present study was aimed to investigate the predictors for new-onset clinically predominant sleep disturbance (CPSD) among heroin users receiving MMT. Methods: This 2-year retrospective study included 152 individuals (127 males and 25 females) with heroin use disorder who visited our MMT clinics for the first time. A univariate Cox proportional hazards regression model (Cox model) was used to estimate the potential factors of subsequent CPSD, followed by a multivariate Cox model to identify significant predictors of CPSD after adjusting for other covariates.Results: Twenty-nine (19.1%) participants developed CPSD during the 2-year period. After forward selection in the Cox model, earlier age at onset of heroin exposure (OR=0.95; P=0.044), lower attendance rate (OR =0.04; P=0.03), greater maximum dose of methadone (OR =1.01; P=0.022), and shorter time to maximum methadone dose (OR =0.98; P=0.007) were significantly associated with new-onset CPSD.Conclusion: We identified predictors that were significantly associated with new-onset CPSD, and clinicians should be aware of sleep disturbance in heroin users receiving MMT with these risk factors. Future studies are necessary to verify our findings and extend the applicability. Keywords: MMT, new-onset sleep disturbance, heroin, CPSDLi DJChung KSWu HCHsu CYYen CFDove Medical PressarticleMethadonenew-onset sleep disturbanceheroinNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 2853-2859 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Methadone new-onset sleep disturbance heroin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Methadone new-onset sleep disturbance heroin Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Li DJ Chung KS Wu HC Hsu CY Yen CF Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan
description	Dian-Jeng Li,1,2 Kuan-Shang Chung,1 Hung-Chi Wu,1 Chih-Yao Hsu,1 Cheng-Fang Yen2,3 1Department of Addiction Science, Kaohsiung Municipal Kai-Syuan Psychiatric Hospital, Kaohsiung, Taiwan; 2Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; 3Department of Psychiatry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan Introduction: Sleep disturbance is a major health concern for heroin users receiving methadone maintenance treatment (MMT). The present study was aimed to investigate the predictors for new-onset clinically predominant sleep disturbance (CPSD) among heroin users receiving MMT. Methods: This 2-year retrospective study included 152 individuals (127 males and 25 females) with heroin use disorder who visited our MMT clinics for the first time. A univariate Cox proportional hazards regression model (Cox model) was used to estimate the potential factors of subsequent CPSD, followed by a multivariate Cox model to identify significant predictors of CPSD after adjusting for other covariates.Results: Twenty-nine (19.1%) participants developed CPSD during the 2-year period. After forward selection in the Cox model, earlier age at onset of heroin exposure (OR=0.95; P=0.044), lower attendance rate (OR =0.04; P=0.03), greater maximum dose of methadone (OR =1.01; P=0.022), and shorter time to maximum methadone dose (OR =0.98; P=0.007) were significantly associated with new-onset CPSD.Conclusion: We identified predictors that were significantly associated with new-onset CPSD, and clinicians should be aware of sleep disturbance in heroin users receiving MMT with these risk factors. Future studies are necessary to verify our findings and extend the applicability. Keywords: MMT, new-onset sleep disturbance, heroin, CPSD
format	article
author	Li DJ Chung KS Wu HC Hsu CY Yen CF
author_facet	Li DJ Chung KS Wu HC Hsu CY Yen CF
author_sort	Li DJ
title	Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan
title_short	Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan
title_full	Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan
title_fullStr	Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan
title_full_unstemmed	Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan
title_sort	predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in taiwan
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/1083f4b732764f45ba4daacddd8dfa4b
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_version_	1718402513590288384

Predictors of sleep disturbance in heroin users receiving methadone maintenance therapy: a naturalistic study in Taiwan

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