Preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles

In order to enhance the aqueous solubility and stability of etoposide preparation,the central composite design-response surface method was used to optimize the prescription technology of etoposide nano-mixed micelles (ETP mPEG-PLA/P123).Based on the results of single factor test,central composite de...

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Autores principales:	Xinxin ZHANG, Jie XU, Yan JIANG, Liyan ZHAO, Wanming ZHANG
Formato:	article
Lenguaje:	ZH
Publicado:	Hebei University of Science and Technology 2021
Materias:	pharmaceutics; etoposide; p123; micelles; uplc; thin film hydration method; central composite design-response surface method Technology T
Acceso en línea:	https://doaj.org/article/108e6cc8cc344cbdae74df9e54cb50b9
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spelling	oai:doaj.org-article:108e6cc8cc344cbdae74df9e54cb50b92021-11-23T07:08:58ZPreparation and evaluation of physicochemical properties of etoposide nano-mixed micelles1008-154210.7535/hbkd.2021yx04009https://doaj.org/article/108e6cc8cc344cbdae74df9e54cb50b92021-08-01T00:00:00Zhttp://xuebao.hebust.edu.cn/hbkjdx/ch/reader/create_pdf.aspx?file_no=b202104009&flag=1&journal_https://doaj.org/toc/1008-1542In order to enhance the aqueous solubility and stability of etoposide preparation,the central composite design-response surface method was used to optimize the prescription technology of etoposide nano-mixed micelles (ETP mPEG-PLA/P123).Based on the results of single factor test,central composite design-response surface method of three factors and five levels was carried out to optimize the prescription technology with drug dosage,the mass ratio of mPEG-PLA and hydration volume as independent variables,and the entrapment efficiency,drug loading and particle size as dependent variables.The critical micelle concentration (CMC) was determined by fluorescence probe method,and the physicochemical properties and release behavior of the prepared micelle preparations were evaluated.The results showed that the optimal prescription of ETP mPEG-PLA/P123 micelle preparation was that mPEG-PLA∶P123=38∶62,the drug dosage was 5 mg,and the hydration volume was 6 mL.After optimization,the entrapment efficiency and drug loading were 874% and 419%,the particle size was 1156 nm,PDI was 0216,and Zeta potential was -163 mV.The CMC value was 17×10-3 </sup>g/L,so mPEG-PLA/P123 micelles had high stability.In vitro release experiments,etoposide could be released from micelles slowly and continuously,up to 80% within 48 h.The optimized ETP mPEG-PLA/P123 nano-mixed micelles were able to enormously improve the aqueous solubility of etoposide,and the micelle preparation had good stability and a certain slow-release effect.The results of this study could provide theoretical guidance for further broadening the range of application of new etoposide preparations.Xinxin ZHANGJie XUYan JIANGLiyan ZHAOWanming ZHANGHebei University of Science and Technologyarticlepharmaceutics; etoposide; p123; micelles; uplc; thin film hydration method; central composite design-response surface methodTechnologyTZHJournal of Hebei University of Science and Technology, Vol 42, Iss 4, Pp 389-399 (2021)
institution	DOAJ
collection	DOAJ
language	ZH
topic	pharmaceutics; etoposide; p123; micelles; uplc; thin film hydration method; central composite design-response surface method Technology T
spellingShingle	pharmaceutics; etoposide; p123; micelles; uplc; thin film hydration method; central composite design-response surface method Technology T Xinxin ZHANG Jie XU Yan JIANG Liyan ZHAO Wanming ZHANG Preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles
description	In order to enhance the aqueous solubility and stability of etoposide preparation,the central composite design-response surface method was used to optimize the prescription technology of etoposide nano-mixed micelles (ETP mPEG-PLA/P123).Based on the results of single factor test,central composite design-response surface method of three factors and five levels was carried out to optimize the prescription technology with drug dosage,the mass ratio of mPEG-PLA and hydration volume as independent variables,and the entrapment efficiency,drug loading and particle size as dependent variables.The critical micelle concentration (CMC) was determined by fluorescence probe method,and the physicochemical properties and release behavior of the prepared micelle preparations were evaluated.The results showed that the optimal prescription of ETP mPEG-PLA/P123 micelle preparation was that mPEG-PLA∶P123=38∶62,the drug dosage was 5 mg,and the hydration volume was 6 mL.After optimization,the entrapment efficiency and drug loading were 874% and 419%,the particle size was 1156 nm,PDI was 0216,and Zeta potential was -163 mV.The CMC value was 17×10-3 </sup>g/L,so mPEG-PLA/P123 micelles had high stability.In vitro release experiments,etoposide could be released from micelles slowly and continuously,up to 80% within 48 h.The optimized ETP mPEG-PLA/P123 nano-mixed micelles were able to enormously improve the aqueous solubility of etoposide,and the micelle preparation had good stability and a certain slow-release effect.The results of this study could provide theoretical guidance for further broadening the range of application of new etoposide preparations.
format	article
author	Xinxin ZHANG Jie XU Yan JIANG Liyan ZHAO Wanming ZHANG
author_facet	Xinxin ZHANG Jie XU Yan JIANG Liyan ZHAO Wanming ZHANG
author_sort	Xinxin ZHANG
title	Preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles
title_short	Preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles
title_full	Preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles
title_fullStr	Preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles
title_full_unstemmed	Preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles
title_sort	preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles
publisher	Hebei University of Science and Technology
publishDate	2021
url	https://doaj.org/article/108e6cc8cc344cbdae74df9e54cb50b9
work_keys_str_mv	AT xinxinzhang preparationandevaluationofphysicochemicalpropertiesofetoposidenanomixedmicelles AT jiexu preparationandevaluationofphysicochemicalpropertiesofetoposidenanomixedmicelles AT yanjiang preparationandevaluationofphysicochemicalpropertiesofetoposidenanomixedmicelles AT liyanzhao preparationandevaluationofphysicochemicalpropertiesofetoposidenanomixedmicelles AT wanmingzhang preparationandevaluationofphysicochemicalpropertiesofetoposidenanomixedmicelles
_version_	1718416807710162944

Preparation and evaluation of physicochemical properties of etoposide nano-mixed micelles

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