The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview

In recent years, vaccine development using ribonucleic acid (RNA) has become the most promising and studied approach to produce safe and effective new vaccines, not only for prophylaxis but also as a treatment. The use of messenger RNA (mRNA) as an immunogenic has several advantages to vaccine devel...

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Autores principales:	Bruna Aparecida Souza Machado, Katharine Valéria Saraiva Hodel, Larissa Moraes dos Santos Fonseca, Luís Alberto Brêda Mascarenhas, Leone Peter Correia da Silva Andrade, Vinícius Pinto Costa Rocha, Milena Botelho Pereira Soares, Peter Berglund, Malcolm S. Duthie, Steven G. Reed, Roberto Badaró
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	RNA vaccines mRNA vaccines saRNA vaccines COVID-19 SARS-CoV-2 Medicine R
Acceso en línea:	https://doaj.org/article/108fa78115ec45d9a3cba35eb8b1af13
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spelling	oai:doaj.org-article:108fa78115ec45d9a3cba35eb8b1af132021-11-25T19:11:30ZThe Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview10.3390/vaccines91113452076-393Xhttps://doaj.org/article/108fa78115ec45d9a3cba35eb8b1af132021-11-01T00:00:00Zhttps://www.mdpi.com/2076-393X/9/11/1345https://doaj.org/toc/2076-393XIn recent years, vaccine development using ribonucleic acid (RNA) has become the most promising and studied approach to produce safe and effective new vaccines, not only for prophylaxis but also as a treatment. The use of messenger RNA (mRNA) as an immunogenic has several advantages to vaccine development compared to other platforms, such as lower coast, the absence of cell cultures, and the possibility to combine different targets. During the COVID-19 pandemic, the use of mRNA as a vaccine became more relevant; two out of the four most widely applied vaccines against COVID-19 in the world are based on this platform. However, even though it presents advantages for vaccine application, mRNA technology faces several pivotal challenges to improve mRNA stability, delivery, and the potential to generate the related protein needed to induce a humoral- and T-cell-mediated immune response. The application of mRNA to vaccine development emerged as a powerful tool to fight against cancer and non-infectious and infectious diseases, for example, and represents a relevant research field for future decades. Based on these advantages, this review emphasizes mRNA and self-amplifying RNA (saRNA) for vaccine development, mainly to fight against COVID-19, together with the challenges related to this approach.Bruna Aparecida Souza MachadoKatharine Valéria Saraiva HodelLarissa Moraes dos Santos FonsecaLuís Alberto Brêda MascarenhasLeone Peter Correia da Silva AndradeVinícius Pinto Costa RochaMilena Botelho Pereira SoaresPeter BerglundMalcolm S. DuthieSteven G. ReedRoberto BadaróMDPI AGarticleRNA vaccinesmRNA vaccinessaRNA vaccinesCOVID-19SARS-CoV-2MedicineRENVaccines, Vol 9, Iss 1345, p 1345 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	RNA vaccines mRNA vaccines saRNA vaccines COVID-19 SARS-CoV-2 Medicine R
spellingShingle	RNA vaccines mRNA vaccines saRNA vaccines COVID-19 SARS-CoV-2 Medicine R Bruna Aparecida Souza Machado Katharine Valéria Saraiva Hodel Larissa Moraes dos Santos Fonseca Luís Alberto Brêda Mascarenhas Leone Peter Correia da Silva Andrade Vinícius Pinto Costa Rocha Milena Botelho Pereira Soares Peter Berglund Malcolm S. Duthie Steven G. Reed Roberto Badaró The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
description	In recent years, vaccine development using ribonucleic acid (RNA) has become the most promising and studied approach to produce safe and effective new vaccines, not only for prophylaxis but also as a treatment. The use of messenger RNA (mRNA) as an immunogenic has several advantages to vaccine development compared to other platforms, such as lower coast, the absence of cell cultures, and the possibility to combine different targets. During the COVID-19 pandemic, the use of mRNA as a vaccine became more relevant; two out of the four most widely applied vaccines against COVID-19 in the world are based on this platform. However, even though it presents advantages for vaccine application, mRNA technology faces several pivotal challenges to improve mRNA stability, delivery, and the potential to generate the related protein needed to induce a humoral- and T-cell-mediated immune response. The application of mRNA to vaccine development emerged as a powerful tool to fight against cancer and non-infectious and infectious diseases, for example, and represents a relevant research field for future decades. Based on these advantages, this review emphasizes mRNA and self-amplifying RNA (saRNA) for vaccine development, mainly to fight against COVID-19, together with the challenges related to this approach.
format	article
author	Bruna Aparecida Souza Machado Katharine Valéria Saraiva Hodel Larissa Moraes dos Santos Fonseca Luís Alberto Brêda Mascarenhas Leone Peter Correia da Silva Andrade Vinícius Pinto Costa Rocha Milena Botelho Pereira Soares Peter Berglund Malcolm S. Duthie Steven G. Reed Roberto Badaró
author_facet	Bruna Aparecida Souza Machado Katharine Valéria Saraiva Hodel Larissa Moraes dos Santos Fonseca Luís Alberto Brêda Mascarenhas Leone Peter Correia da Silva Andrade Vinícius Pinto Costa Rocha Milena Botelho Pereira Soares Peter Berglund Malcolm S. Duthie Steven G. Reed Roberto Badaró
author_sort	Bruna Aparecida Souza Machado
title	The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
title_short	The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
title_full	The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
title_fullStr	The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
title_full_unstemmed	The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview
title_sort	importance of rna-based vaccines in the fight against covid-19: an overview
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/108fa78115ec45d9a3cba35eb8b1af13
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The Importance of RNA-Based Vaccines in the Fight against COVID-19: An Overview

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