A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci

Abstract Vancomycin-resistant enterococci (VRE) are prominent causes of nosocomial infections. Japanese traditional (Kampo) medicine promotes intestinal immunity and protects against bacterial infections. We assessed potential differences in the clinical course of VRE-positive patients, based on the...

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Autores principales:	Junko Kohno, Tsuyoshi Kawamura, Akiko Kikuchi, Tetsuya Akaishi, Shin Takayama, Tadashi Ishii
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1090192d3ba94fb69ef6c8c5bf8427c0
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spelling	oai:doaj.org-article:1090192d3ba94fb69ef6c8c5bf8427c02021-12-02T15:00:59ZA Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci10.1038/s41598-021-90890-42045-2322https://doaj.org/article/1090192d3ba94fb69ef6c8c5bf8427c02021-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-90890-4https://doaj.org/toc/2045-2322Abstract Vancomycin-resistant enterococci (VRE) are prominent causes of nosocomial infections. Japanese traditional (Kampo) medicine promotes intestinal immunity and protects against bacterial infections. We assessed potential differences in the clinical course of VRE-positive patients, based on their characteristics and treatment with Kampo medicines. This retrospective observational study collected data from VRE-positive patients from August 2018 to July 2019 at a tertiary-care hospital in Japan. The data of 122 consecutive VRE-positive inpatients were analyzed. Sixty-nine patients were treated with probiotics, among whom, 18 were further treated with Kampo medicines. Twenty-six of the 122 patients subsequently died. In univariate analyses, subsequent VRE negative conversion significantly reduced the mortality of VRE-detected patients (p = .0003). Administration of probiotics (p = .0065) and Kampo medicines with probiotics (p = .0002), especially of the Kampo medicine hochuekkito (p = .0014), and a higher serum albumin level positively contributed to the subsequent VRE negative conversion. Multivariate analyses demonstrated that Kampo medicines and body mass index contributed to VRE negative conversion. Hochuekkito shortened the time needed for VRE negative conversion (p = 0.0485). Administration of Kampo medicines, especially of hochuekkito, in addition to probiotics in VRE patients may promote VRE negative conversion.Junko KohnoTsuyoshi KawamuraAkiko KikuchiTetsuya AkaishiShin TakayamaTadashi IshiiNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Junko Kohno Tsuyoshi Kawamura Akiko Kikuchi Tetsuya Akaishi Shin Takayama Tadashi Ishii A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci
description	Abstract Vancomycin-resistant enterococci (VRE) are prominent causes of nosocomial infections. Japanese traditional (Kampo) medicine promotes intestinal immunity and protects against bacterial infections. We assessed potential differences in the clinical course of VRE-positive patients, based on their characteristics and treatment with Kampo medicines. This retrospective observational study collected data from VRE-positive patients from August 2018 to July 2019 at a tertiary-care hospital in Japan. The data of 122 consecutive VRE-positive inpatients were analyzed. Sixty-nine patients were treated with probiotics, among whom, 18 were further treated with Kampo medicines. Twenty-six of the 122 patients subsequently died. In univariate analyses, subsequent VRE negative conversion significantly reduced the mortality of VRE-detected patients (p = .0003). Administration of probiotics (p = .0065) and Kampo medicines with probiotics (p = .0002), especially of the Kampo medicine hochuekkito (p = .0014), and a higher serum albumin level positively contributed to the subsequent VRE negative conversion. Multivariate analyses demonstrated that Kampo medicines and body mass index contributed to VRE negative conversion. Hochuekkito shortened the time needed for VRE negative conversion (p = 0.0485). Administration of Kampo medicines, especially of hochuekkito, in addition to probiotics in VRE patients may promote VRE negative conversion.
format	article
author	Junko Kohno Tsuyoshi Kawamura Akiko Kikuchi Tetsuya Akaishi Shin Takayama Tadashi Ishii
author_facet	Junko Kohno Tsuyoshi Kawamura Akiko Kikuchi Tetsuya Akaishi Shin Takayama Tadashi Ishii
author_sort	Junko Kohno
title	A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci
title_short	A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci
title_full	A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci
title_fullStr	A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci
title_full_unstemmed	A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci
title_sort	japanese traditional medicine hochuekkito promotes negative conversion of vancomycin-resistant enterococci
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1090192d3ba94fb69ef6c8c5bf8427c0
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A Japanese traditional medicine Hochuekkito promotes negative conversion of vancomycin-resistant Enterococci

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