A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery

Swift vaccination is necessary as a response to disease outbreaks and pandemics; otherwise, the species under attack is at risk of a high fatality rate or even mass extinction. Statistics suggest that at least 16 billion injections are administered worldwide every year. Such a high rate of needle/sy...

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Autores principales:	Mojiz Abbas Trimzi, Young-Bog Ham
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	needle-free liquid jet injection system compressed-air and spring-driven controlled release repeated injection Pharmacy and materia medica RS1-441
Acceso en línea:	https://doaj.org/article/1091d57bb4c7402db47ab670677ca006
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spelling	oai:doaj.org-article:1091d57bb4c7402db47ab670677ca0062021-11-25T18:40:33ZA Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery10.3390/pharmaceutics131117701999-4923https://doaj.org/article/1091d57bb4c7402db47ab670677ca0062021-10-01T00:00:00Zhttps://www.mdpi.com/1999-4923/13/11/1770https://doaj.org/toc/1999-4923Swift vaccination is necessary as a response to disease outbreaks and pandemics; otherwise, the species under attack is at risk of a high fatality rate or even mass extinction. Statistics suggest that at least 16 billion injections are administered worldwide every year. Such a high rate of needle/syringe injection administration worldwide is alarming due to the risk of needle-stick injuries, disease spread due to cross-contamination and the reuse of needles, and the misuse of needles. In addition, there are production, handling, and disposal costs. Needle phobia is an additional issue faced by many recipients of injections with needles. In addition to a detailed literature review highlighting the need for needle-free injection systems, a compressed air-driven needle-free jet injection system with a hydro-pneumatic mechanism was designed and developed by employing an axiomatic design approach. The proposed injection system has higher flexibility, uninterrupted force generation, and provides the possibility of delivering repeated injections at different tissue depths from the dermis to the muscle (depending on the drug delivery requirements) by controlling the inlet compressed air pressure. The designed needle-free jet injector consists of two primary circuits: the pneumatic and the hydraulic circuit. The pneumatic circuit is responsible for driving, pressurizing, and repeatability. The hydraulic circuit precisely injects and contains the liquid jet, allowing us to control the volume of the liquid jet at elevated pressure by offering flexibility in the dose volume per injection. Finally, in this paper we report on the successful design and working model of an air-driven needle-free jet injector for 0.2–0.5 mL drug delivery by ex vivo experimental validation.Mojiz Abbas TrimziYoung-Bog HamMDPI AGarticleneedle-freeliquid jetinjection systemcompressed-air and spring-drivencontrolled releaserepeated injectionPharmacy and materia medicaRS1-441ENPharmaceutics, Vol 13, Iss 1770, p 1770 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	needle-free liquid jet injection system compressed-air and spring-driven controlled release repeated injection Pharmacy and materia medica RS1-441
spellingShingle	needle-free liquid jet injection system compressed-air and spring-driven controlled release repeated injection Pharmacy and materia medica RS1-441 Mojiz Abbas Trimzi Young-Bog Ham A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery
description	Swift vaccination is necessary as a response to disease outbreaks and pandemics; otherwise, the species under attack is at risk of a high fatality rate or even mass extinction. Statistics suggest that at least 16 billion injections are administered worldwide every year. Such a high rate of needle/syringe injection administration worldwide is alarming due to the risk of needle-stick injuries, disease spread due to cross-contamination and the reuse of needles, and the misuse of needles. In addition, there are production, handling, and disposal costs. Needle phobia is an additional issue faced by many recipients of injections with needles. In addition to a detailed literature review highlighting the need for needle-free injection systems, a compressed air-driven needle-free jet injection system with a hydro-pneumatic mechanism was designed and developed by employing an axiomatic design approach. The proposed injection system has higher flexibility, uninterrupted force generation, and provides the possibility of delivering repeated injections at different tissue depths from the dermis to the muscle (depending on the drug delivery requirements) by controlling the inlet compressed air pressure. The designed needle-free jet injector consists of two primary circuits: the pneumatic and the hydraulic circuit. The pneumatic circuit is responsible for driving, pressurizing, and repeatability. The hydraulic circuit precisely injects and contains the liquid jet, allowing us to control the volume of the liquid jet at elevated pressure by offering flexibility in the dose volume per injection. Finally, in this paper we report on the successful design and working model of an air-driven needle-free jet injector for 0.2–0.5 mL drug delivery by ex vivo experimental validation.
format	article
author	Mojiz Abbas Trimzi Young-Bog Ham
author_facet	Mojiz Abbas Trimzi Young-Bog Ham
author_sort	Mojiz Abbas Trimzi
title	A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery
title_short	A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery
title_full	A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery
title_fullStr	A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery
title_full_unstemmed	A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery
title_sort	needle-free jet injection system for controlled release and repeated biopharmaceutical delivery
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/1091d57bb4c7402db47ab670677ca006
work_keys_str_mv	AT mojizabbastrimzi aneedlefreejetinjectionsystemforcontrolledreleaseandrepeatedbiopharmaceuticaldelivery AT youngbogham aneedlefreejetinjectionsystemforcontrolledreleaseandrepeatedbiopharmaceuticaldelivery AT mojizabbastrimzi needlefreejetinjectionsystemforcontrolledreleaseandrepeatedbiopharmaceuticaldelivery AT youngbogham needlefreejetinjectionsystemforcontrolledreleaseandrepeatedbiopharmaceuticaldelivery
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A Needle-Free Jet Injection System for Controlled Release and Repeated Biopharmaceutical Delivery

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