Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study

Abstract Circulating levels of inflammatory proteins have to be prognostic markers of all-cause mortality. α1-Antitrypsin (AAT) is a major inflammatory plasma protein, but its association with all-cause mortality is unclear. We aimed to evaluate the prognostic significance of AAT levels for all-caus...

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Autores principales:	Yasuharu Tabara, Kazuya Setoh, Takahisa Kawaguchi, Shinji Kosugi, Takeo Nakayama, Fumihiko Matsuda
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/1096629d25124e6ea232d1b137bf1f50
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spelling	oai:doaj.org-article:1096629d25124e6ea232d1b137bf1f502021-12-02T15:09:23ZAssociation between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study10.1038/s41598-021-96833-32045-2322https://doaj.org/article/1096629d25124e6ea232d1b137bf1f502021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-96833-3https://doaj.org/toc/2045-2322Abstract Circulating levels of inflammatory proteins have to be prognostic markers of all-cause mortality. α1-Antitrypsin (AAT) is a major inflammatory plasma protein, but its association with all-cause mortality is unclear. We aimed to evaluate the prognostic significance of AAT levels for all-cause mortality. Study participants comprised 9682 community residents (53.5 ± 13.3 years old). During the 9.8-year follow-up period, 313 participants died from any cause. The mortality rate increased linearly with AAT quintiles (Q1, 18.2; Q2, 24.7; Q3, 23.8; Q4, 31.9; Q5, 64.6 per 10,000 person-years). There were significant correlations between AAT and high-sensitivity C-reactive protein (hsCRP) levels (correlation coefficient, 0.331; P < 0.001). However, the Cox model analysis, when adjusted for possible covariates including hsCRP, identified the fifth AAT quintile as a risk factor for all-cause death (hazard ratio, 2.12 [95% confidence interval, 1.41–3.18]; P < 0.001). An analysis of participants older than 50 years (hazard ratio, 1.98, P < 0.001) yielded similar results. The hazard ratio increased proportionately in combination with high AAT and high hsCRP levels, and the highest hazard ratio reached 4.51 (95% confidence interval, 3.14–6.54, P < 0.001). High AAT levels were determined to be an independent risk factor for mortality in the general population.Yasuharu TabaraKazuya SetohTakahisa KawaguchiShinji KosugiTakeo NakayamaFumihiko MatsudaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Yasuharu Tabara Kazuya Setoh Takahisa Kawaguchi Shinji Kosugi Takeo Nakayama Fumihiko Matsuda Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study
description	Abstract Circulating levels of inflammatory proteins have to be prognostic markers of all-cause mortality. α1-Antitrypsin (AAT) is a major inflammatory plasma protein, but its association with all-cause mortality is unclear. We aimed to evaluate the prognostic significance of AAT levels for all-cause mortality. Study participants comprised 9682 community residents (53.5 ± 13.3 years old). During the 9.8-year follow-up period, 313 participants died from any cause. The mortality rate increased linearly with AAT quintiles (Q1, 18.2; Q2, 24.7; Q3, 23.8; Q4, 31.9; Q5, 64.6 per 10,000 person-years). There were significant correlations between AAT and high-sensitivity C-reactive protein (hsCRP) levels (correlation coefficient, 0.331; P < 0.001). However, the Cox model analysis, when adjusted for possible covariates including hsCRP, identified the fifth AAT quintile as a risk factor for all-cause death (hazard ratio, 2.12 [95% confidence interval, 1.41–3.18]; P < 0.001). An analysis of participants older than 50 years (hazard ratio, 1.98, P < 0.001) yielded similar results. The hazard ratio increased proportionately in combination with high AAT and high hsCRP levels, and the highest hazard ratio reached 4.51 (95% confidence interval, 3.14–6.54, P < 0.001). High AAT levels were determined to be an independent risk factor for mortality in the general population.
format	article
author	Yasuharu Tabara Kazuya Setoh Takahisa Kawaguchi Shinji Kosugi Takeo Nakayama Fumihiko Matsuda
author_facet	Yasuharu Tabara Kazuya Setoh Takahisa Kawaguchi Shinji Kosugi Takeo Nakayama Fumihiko Matsuda
author_sort	Yasuharu Tabara
title	Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study
title_short	Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study
title_full	Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study
title_fullStr	Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study
title_full_unstemmed	Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study
title_sort	association between serum α1-antitrypsin levels and all-cause mortality in the general population: the nagahama study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/1096629d25124e6ea232d1b137bf1f50
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Association between serum α1-antitrypsin levels and all-cause mortality in the general population: the Nagahama study

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