Cell Cycle Dysregulation and Renal Fibrosis

Precise regulation of cell cycle is essential for tissue homeostasis and development, while cell cycle dysregulation is associated with many human diseases including renal fibrosis, a common process of various chronic kidney diseases progressing to end-stage renal disease. Under normal physiological...

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Autores principales:	Yun-Shan Wu, Shan Liang, Dong-Yi Li, Jun-Hao Wen, Ji-Xin Tang, Hua-Feng Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	cell cycle arrest over proliferation cell senescence senescence associated secretory phenotype renal fibrosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/10967b305d0f400d8b8c1ebb88f738d4
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spelling	oai:doaj.org-article:10967b305d0f400d8b8c1ebb88f738d42021-12-01T01:33:14ZCell Cycle Dysregulation and Renal Fibrosis2296-634X10.3389/fcell.2021.714320https://doaj.org/article/10967b305d0f400d8b8c1ebb88f738d42021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fcell.2021.714320/fullhttps://doaj.org/toc/2296-634XPrecise regulation of cell cycle is essential for tissue homeostasis and development, while cell cycle dysregulation is associated with many human diseases including renal fibrosis, a common process of various chronic kidney diseases progressing to end-stage renal disease. Under normal physiological conditions, most of the renal cells are post-mitotic quiescent cells arrested in the G0 phase of cell cycle and renal cells turnover is very low. Injuries induced by toxins, hypoxia, and metabolic disorders can stimulate renal cells to enter the cell cycle, which is essential for kidney regeneration and renal function restoration. However, more severe or repeated injuries will lead to maladaptive repair, manifesting as cell cycle arrest or overproliferation of renal cells, both of which are closely related to renal fibrosis. Thus, cell cycle dysregulation of renal cells is a potential therapeutic target for the treatment of renal fibrosis. In this review, we focus on cell cycle regulation of renal cells in healthy and diseased kidney, discussing the role of cell cycle dysregulation of renal cells in renal fibrosis. Better understanding of the function of cell cycle dysregulation in renal fibrosis is essential for the development of therapeutics to halt renal fibrosis progression or promote regression.Yun-Shan WuShan LiangDong-Yi LiJun-Hao WenJi-Xin TangJi-Xin TangHua-Feng LiuFrontiers Media S.A.articlecell cycle arrestover proliferationcell senescencesenescence associated secretory phenotyperenal fibrosisBiology (General)QH301-705.5ENFrontiers in Cell and Developmental Biology, Vol 9 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cell cycle arrest over proliferation cell senescence senescence associated secretory phenotype renal fibrosis Biology (General) QH301-705.5
spellingShingle	cell cycle arrest over proliferation cell senescence senescence associated secretory phenotype renal fibrosis Biology (General) QH301-705.5 Yun-Shan Wu Shan Liang Dong-Yi Li Jun-Hao Wen Ji-Xin Tang Ji-Xin Tang Hua-Feng Liu Cell Cycle Dysregulation and Renal Fibrosis
description	Precise regulation of cell cycle is essential for tissue homeostasis and development, while cell cycle dysregulation is associated with many human diseases including renal fibrosis, a common process of various chronic kidney diseases progressing to end-stage renal disease. Under normal physiological conditions, most of the renal cells are post-mitotic quiescent cells arrested in the G0 phase of cell cycle and renal cells turnover is very low. Injuries induced by toxins, hypoxia, and metabolic disorders can stimulate renal cells to enter the cell cycle, which is essential for kidney regeneration and renal function restoration. However, more severe or repeated injuries will lead to maladaptive repair, manifesting as cell cycle arrest or overproliferation of renal cells, both of which are closely related to renal fibrosis. Thus, cell cycle dysregulation of renal cells is a potential therapeutic target for the treatment of renal fibrosis. In this review, we focus on cell cycle regulation of renal cells in healthy and diseased kidney, discussing the role of cell cycle dysregulation of renal cells in renal fibrosis. Better understanding of the function of cell cycle dysregulation in renal fibrosis is essential for the development of therapeutics to halt renal fibrosis progression or promote regression.
format	article
author	Yun-Shan Wu Shan Liang Dong-Yi Li Jun-Hao Wen Ji-Xin Tang Ji-Xin Tang Hua-Feng Liu
author_facet	Yun-Shan Wu Shan Liang Dong-Yi Li Jun-Hao Wen Ji-Xin Tang Ji-Xin Tang Hua-Feng Liu
author_sort	Yun-Shan Wu
title	Cell Cycle Dysregulation and Renal Fibrosis
title_short	Cell Cycle Dysregulation and Renal Fibrosis
title_full	Cell Cycle Dysregulation and Renal Fibrosis
title_fullStr	Cell Cycle Dysregulation and Renal Fibrosis
title_full_unstemmed	Cell Cycle Dysregulation and Renal Fibrosis
title_sort	cell cycle dysregulation and renal fibrosis
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/10967b305d0f400d8b8c1ebb88f738d4
work_keys_str_mv	AT yunshanwu cellcycledysregulationandrenalfibrosis AT shanliang cellcycledysregulationandrenalfibrosis AT dongyili cellcycledysregulationandrenalfibrosis AT junhaowen cellcycledysregulationandrenalfibrosis AT jixintang cellcycledysregulationandrenalfibrosis AT jixintang cellcycledysregulationandrenalfibrosis AT huafengliu cellcycledysregulationandrenalfibrosis
_version_	1718405944636866560

Cell Cycle Dysregulation and Renal Fibrosis

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