Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses

Abstract Polyols are effective against caries-causing streptococci but the effect on oropharynx-derived pyogenic streptococci is not well characterised. We aimed to study the effect of erythritol (ERY) and xylitol (XYL) against Streptococcus pyogenes isolated from peritonsillar abscesses (PTA). We u...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Siiri Kõljalg, Risto Vaikjärv, Imbi Smidt, Tiiu Rööp, Anirikh Chakrabarti, Priit Kasenõmm, Reet Mändar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/109be5715a334cb89eb419cd1d9bb7bb
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:109be5715a334cb89eb419cd1d9bb7bb
record_format	dspace
spelling	oai:doaj.org-article:109be5715a334cb89eb419cd1d9bb7bb2021-12-02T14:53:43ZEffect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses10.1038/s41598-021-95367-y2045-2322https://doaj.org/article/109be5715a334cb89eb419cd1d9bb7bb2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-95367-yhttps://doaj.org/toc/2045-2322Abstract Polyols are effective against caries-causing streptococci but the effect on oropharynx-derived pyogenic streptococci is not well characterised. We aimed to study the effect of erythritol (ERY) and xylitol (XYL) against Streptococcus pyogenes isolated from peritonsillar abscesses (PTA). We used 31 clinical isolates and 5 throat culture collection strains. Inhibition of bacterial growth by polyols at 2.5%, 5% and 10% concentrations was studied and the results were scored. Amylase levels in PTA pus were compared to polyol effectivity scores (PES). Growth curves of four S. pyogenes isolates were analysed. Our study showed that XYL was more effective than ERY inhibiting 71–97% and 48–84% of isolates, respectively, depending of concentrations. 48% of clinical and all throat strains were inhibited by polyols in all concentrations (PES 3). PES was negative or zero in 26% of the isolates in the presence of ERY and in 19% of XYL. ERY enhanced the growth of S. pyogenes isolated from pus with high amylase levels. Polyols in all concentrations inhibited the growth in exponential phase. In conclusion, ERY and XYL are potent growth inhibitors of S. pyogenes isolated from PTA. Therefore, ERY and XYL may have potential in preventing PTA in the patients with frequent tonsillitis episodes.Siiri KõljalgRisto VaikjärvImbi SmidtTiiu RööpAnirikh ChakrabartiPriit KasenõmmReet MändarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Siiri Kõljalg Risto Vaikjärv Imbi Smidt Tiiu Rööp Anirikh Chakrabarti Priit Kasenõmm Reet Mändar Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses
description	Abstract Polyols are effective against caries-causing streptococci but the effect on oropharynx-derived pyogenic streptococci is not well characterised. We aimed to study the effect of erythritol (ERY) and xylitol (XYL) against Streptococcus pyogenes isolated from peritonsillar abscesses (PTA). We used 31 clinical isolates and 5 throat culture collection strains. Inhibition of bacterial growth by polyols at 2.5%, 5% and 10% concentrations was studied and the results were scored. Amylase levels in PTA pus were compared to polyol effectivity scores (PES). Growth curves of four S. pyogenes isolates were analysed. Our study showed that XYL was more effective than ERY inhibiting 71–97% and 48–84% of isolates, respectively, depending of concentrations. 48% of clinical and all throat strains were inhibited by polyols in all concentrations (PES 3). PES was negative or zero in 26% of the isolates in the presence of ERY and in 19% of XYL. ERY enhanced the growth of S. pyogenes isolated from pus with high amylase levels. Polyols in all concentrations inhibited the growth in exponential phase. In conclusion, ERY and XYL are potent growth inhibitors of S. pyogenes isolated from PTA. Therefore, ERY and XYL may have potential in preventing PTA in the patients with frequent tonsillitis episodes.
format	article
author	Siiri Kõljalg Risto Vaikjärv Imbi Smidt Tiiu Rööp Anirikh Chakrabarti Priit Kasenõmm Reet Mändar
author_facet	Siiri Kõljalg Risto Vaikjärv Imbi Smidt Tiiu Rööp Anirikh Chakrabarti Priit Kasenõmm Reet Mändar
author_sort	Siiri Kõljalg
title	Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses
title_short	Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses
title_full	Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses
title_fullStr	Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses
title_full_unstemmed	Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses
title_sort	effect of erythritol and xylitol on streptococcus pyogenes causing peritonsillar abscesses
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/109be5715a334cb89eb419cd1d9bb7bb
work_keys_str_mv	AT siirikoljalg effectoferythritolandxylitolonstreptococcuspyogenescausingperitonsillarabscesses AT ristovaikjarv effectoferythritolandxylitolonstreptococcuspyogenescausingperitonsillarabscesses AT imbismidt effectoferythritolandxylitolonstreptococcuspyogenescausingperitonsillarabscesses AT tiiuroop effectoferythritolandxylitolonstreptococcuspyogenescausingperitonsillarabscesses AT anirikhchakrabarti effectoferythritolandxylitolonstreptococcuspyogenescausingperitonsillarabscesses AT priitkasenomm effectoferythritolandxylitolonstreptococcuspyogenescausingperitonsillarabscesses AT reetmandar effectoferythritolandxylitolonstreptococcuspyogenescausingperitonsillarabscesses
_version_	1718389366807592960

Effect of erythritol and xylitol on Streptococcus pyogenes causing peritonsillar abscesses

Ejemplares similares