Therapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model

Background: Medicinal plants contain organic chemicals with different properties. As synthetic medications can create deleterious effects, therefore, use of safe natural medicinal adjuncts like Stevia rebaudiana is endorsed. Objectives: The purpose of this study was to assess the antidiabetic, a...

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Autores principales:	Fatma Hussain, Javaria Hafeez
Formato:	article
Lenguaje:	EN
Publicado:	Jinnah University for Women 2021
Materias:	Antidiabetic, Antioxidant, Hepatoprotective, Renoprotective, Stevia rebaudiana. Medicine R Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/109cbf87596a492d8a82c82659de4b23
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spelling	oai:doaj.org-article:109cbf87596a492d8a82c82659de4b232021-11-25T06:47:15ZTherapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model10.37962/jbas.v12i1.3442305-87222521-8573https://doaj.org/article/109cbf87596a492d8a82c82659de4b232021-07-01T00:00:00Zhttp://jbas.juw.edu.pk/index.php/JBAS/article/view/344https://doaj.org/toc/2305-8722https://doaj.org/toc/2521-8573 Background: Medicinal plants contain organic chemicals with different properties. As synthetic medications can create deleterious effects, therefore, use of safe natural medicinal adjuncts like Stevia rebaudiana is endorsed. Objectives: The purpose of this study was to assess the antidiabetic, antioxidant, antihyperlipidemic, hepatoprotective and renoprotective attributes of Stevia rebaudiana leaves in the diabetic rat model. Methodology: Single dose of alloxan monohydrate was given to induce Diabetes mellitus in the rats. Plant extract treatment along with synthetic drug glibenclamide was given to rats for about 28 days to check their efficacies (antidiabetic, antioxidant, antihyperlipidemic, hepatoprotective and reno-protective) by using commercially available kits. Results: Treatment showed a significant decrease in blood glucose, glycated hemoglobin HbA1c, and a rise in insulin, although it could not normalize these biomarkers after 28 days of treatment. Catalase (CAT) activity was restored yet it was not significantly improved in the case of Superoxide Dismutase (SOD) and Reduced Glutathione (GSH). Changes in lipid peroxidation products were trivial. Ingestion of Stevia rebaudiana significantly reduced Alanine Transaminase (ALT) and Aspartate Transaminase (AST) levels, however, changes in Gamma-Glutamyl Transpeptidase (GGT), and Total Protein (TP) were not significant. Similarly, treatment with Stevia rebaudiana reduced serum urea, creatinine and urinary albumin in diabetic animals. Conclusion: It is established that Stevia rebaudiana leaves have multiple benefits and can be an exceptional nutraceutical. Fatma HussainJavaria HafeezJinnah University for WomenarticleAntidiabetic, Antioxidant, Hepatoprotective, Renoprotective, Stevia rebaudiana.MedicineRBiology (General)QH301-705.5ENRADS Journal of Biological Research & Applied Science, Vol 12, Iss 1 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Antidiabetic, Antioxidant, Hepatoprotective, Renoprotective, Stevia rebaudiana. Medicine R Biology (General) QH301-705.5
spellingShingle	Antidiabetic, Antioxidant, Hepatoprotective, Renoprotective, Stevia rebaudiana. Medicine R Biology (General) QH301-705.5 Fatma Hussain Javaria Hafeez Therapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model
description	Background: Medicinal plants contain organic chemicals with different properties. As synthetic medications can create deleterious effects, therefore, use of safe natural medicinal adjuncts like Stevia rebaudiana is endorsed. Objectives: The purpose of this study was to assess the antidiabetic, antioxidant, antihyperlipidemic, hepatoprotective and renoprotective attributes of Stevia rebaudiana leaves in the diabetic rat model. Methodology: Single dose of alloxan monohydrate was given to induce Diabetes mellitus in the rats. Plant extract treatment along with synthetic drug glibenclamide was given to rats for about 28 days to check their efficacies (antidiabetic, antioxidant, antihyperlipidemic, hepatoprotective and reno-protective) by using commercially available kits. Results: Treatment showed a significant decrease in blood glucose, glycated hemoglobin HbA1c, and a rise in insulin, although it could not normalize these biomarkers after 28 days of treatment. Catalase (CAT) activity was restored yet it was not significantly improved in the case of Superoxide Dismutase (SOD) and Reduced Glutathione (GSH). Changes in lipid peroxidation products were trivial. Ingestion of Stevia rebaudiana significantly reduced Alanine Transaminase (ALT) and Aspartate Transaminase (AST) levels, however, changes in Gamma-Glutamyl Transpeptidase (GGT), and Total Protein (TP) were not significant. Similarly, treatment with Stevia rebaudiana reduced serum urea, creatinine and urinary albumin in diabetic animals. Conclusion: It is established that Stevia rebaudiana leaves have multiple benefits and can be an exceptional nutraceutical.
format	article
author	Fatma Hussain Javaria Hafeez
author_facet	Fatma Hussain Javaria Hafeez
author_sort	Fatma Hussain
title	Therapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model
title_short	Therapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model
title_full	Therapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model
title_fullStr	Therapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model
title_full_unstemmed	Therapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model
title_sort	therapeutic attributes of stevia rebaudiana leaves in diabetic animal model
publisher	Jinnah University for Women
publishDate	2021
url	https://doaj.org/article/109cbf87596a492d8a82c82659de4b23
work_keys_str_mv	AT fatmahussain therapeuticattributesofsteviarebaudianaleavesindiabeticanimalmodel AT javariahafeez therapeuticattributesofsteviarebaudianaleavesindiabeticanimalmodel
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Therapeutic Attributes of Stevia rebaudiana Leaves in Diabetic Animal Model

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