Clinical Implications of Intestinal Barrier Damage in Psoriasis

Mariusz Sikora,1 Albert Stec,1 Magdalena Chrabaszcz,1 Joanna Giebultowicz,2 Emilia Samborowska,3 Radoslaw Jazwiec,3 Michal Dadlez,3,4 Malgorzata Olszewska,1 Lidia Rudnicka1 1Department of Dermatology, Medical University of Warsaw, Warsaw, Poland; 2Department of Bioanalysis and Drug Analysis, Faculty...

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Autores principales:	Sikora M, Stec A, Chrabaszcz M, Giebultowicz J, Samborowska E, Jazwiec R, Dadlez M, Olszewska M, Rudnicka L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	gut barrier microbiome psoriasis systemic sclerosis tmao. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/109e863ee3de4425bdf43dd67cbb8eb5
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spelling	oai:doaj.org-article:109e863ee3de4425bdf43dd67cbb8eb52021-12-02T13:53:34ZClinical Implications of Intestinal Barrier Damage in Psoriasis1178-7031https://doaj.org/article/109e863ee3de4425bdf43dd67cbb8eb52021-01-01T00:00:00Zhttps://www.dovepress.com/clinical-implications-of-intestinal-barrier-damage-in-psoriasis-peer-reviewed-article-JIRhttps://doaj.org/toc/1178-7031Mariusz Sikora,1 Albert Stec,1 Magdalena Chrabaszcz,1 Joanna Giebultowicz,2 Emilia Samborowska,3 Radoslaw Jazwiec,3 Michal Dadlez,3,4 Malgorzata Olszewska,1 Lidia Rudnicka1 1Department of Dermatology, Medical University of Warsaw, Warsaw, Poland; 2Department of Bioanalysis and Drug Analysis, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Warsaw, Poland; 3Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland; 4Institute of Genetics and Biotechnology, Biology Department, Warsaw University, Warsaw, PolandCorrespondence: Mariusz SikoraDepartment of Dermatology, Medical University of Warsaw, Koszykowa 82A, Warsaw 02-008, PolandTel +48 22 502 13 24Fax +48 22 502 21 06Email msikora@wum.edu.plBackground: An increasing amount of evidence suggests an association between increased intestinal permeability and the pathogenesis of chronic inflammatory diseases. However, the clinical significance of gut barrier dysfunction in psoriasis remains to be established.Objective: To evaluate whether there are differences in disease activity, the severity of gastrointestinal symptoms and the blood concentration of bacterial metabolites in psoriatic patients with a normal and altered intestinal barrier.Patients and Methods: Gut barrier integrity was assessed with the serum concentrations of claudin-3, a modulator of intestinal tight junctions and an intestinal fatty acid-binding protein, a marker of enterocyte damage. Gastrointestinal symptoms were evaluated with a validated questionnaire. The concentration of trimethylamine N-oxide (TMAO), a gut microbiota-associated metabolite, was measured with high-performance liquid chromatography.Results: One hundred and fourteen patients with psoriasis were finally enrolled in the study – 68 with an altered gut barrier and 46 with a properly functioning intestinal barrier. Patients with an altered gut barrier showed a significantly higher score in the Gastrointestinal Symptom Rating Scale (3.20 vs 1.46, p< 0.001). Moreover, patients with psoriasis and a disrupted intestinal barrier demonstrated a higher disease activity (PASI: 19.7 vs 10.3, p< 0.001) and systemic inflammatory parameters (neutrophil-to-lymphocyte ratio: 2.86 vs 1.71, p< 0.001; C-reactive protein 3.76 vs 1.92; p< 0.05). The marker of bacterial translocation was significantly higher in psoriatic patients with damaged gut integrity (TMAO: 375.7± 51.9 vs 119.4± 27.5 ng/mL; p< 0.05).Conclusion: The altered gut barrier in psoriasis is associated with gastrointestinal symptoms, systemic inflammatory profile and the increased blood concentration of gut microbiota-derived metabolite – TMAO. Intestinal barrier modulation represents a new promising therapeutic approach.Keywords: gut barrier, microbiome, psoriasis, systemic sclerosis, TMAOSikora MStec AChrabaszcz MGiebultowicz JSamborowska EJazwiec RDadlez MOlszewska MRudnicka LDove Medical Pressarticlegut barriermicrobiomepsoriasissystemic sclerosistmao.PathologyRB1-214Therapeutics. PharmacologyRM1-950ENJournal of Inflammation Research, Vol Volume 14, Pp 237-243 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gut barrier microbiome psoriasis systemic sclerosis tmao. Pathology RB1-214 Therapeutics. Pharmacology RM1-950
spellingShingle	gut barrier microbiome psoriasis systemic sclerosis tmao. Pathology RB1-214 Therapeutics. Pharmacology RM1-950 Sikora M Stec A Chrabaszcz M Giebultowicz J Samborowska E Jazwiec R Dadlez M Olszewska M Rudnicka L Clinical Implications of Intestinal Barrier Damage in Psoriasis
description	Mariusz Sikora,1 Albert Stec,1 Magdalena Chrabaszcz,1 Joanna Giebultowicz,2 Emilia Samborowska,3 Radoslaw Jazwiec,3 Michal Dadlez,3,4 Malgorzata Olszewska,1 Lidia Rudnicka1 1Department of Dermatology, Medical University of Warsaw, Warsaw, Poland; 2Department of Bioanalysis and Drug Analysis, Faculty of Pharmacy with the Laboratory Medicine Division, Medical University of Warsaw, Warsaw, Poland; 3Mass Spectrometry Laboratory, Institute of Biochemistry and Biophysics, Polish Academy of Sciences, Warsaw, Poland; 4Institute of Genetics and Biotechnology, Biology Department, Warsaw University, Warsaw, PolandCorrespondence: Mariusz SikoraDepartment of Dermatology, Medical University of Warsaw, Koszykowa 82A, Warsaw 02-008, PolandTel +48 22 502 13 24Fax +48 22 502 21 06Email msikora@wum.edu.plBackground: An increasing amount of evidence suggests an association between increased intestinal permeability and the pathogenesis of chronic inflammatory diseases. However, the clinical significance of gut barrier dysfunction in psoriasis remains to be established.Objective: To evaluate whether there are differences in disease activity, the severity of gastrointestinal symptoms and the blood concentration of bacterial metabolites in psoriatic patients with a normal and altered intestinal barrier.Patients and Methods: Gut barrier integrity was assessed with the serum concentrations of claudin-3, a modulator of intestinal tight junctions and an intestinal fatty acid-binding protein, a marker of enterocyte damage. Gastrointestinal symptoms were evaluated with a validated questionnaire. The concentration of trimethylamine N-oxide (TMAO), a gut microbiota-associated metabolite, was measured with high-performance liquid chromatography.Results: One hundred and fourteen patients with psoriasis were finally enrolled in the study – 68 with an altered gut barrier and 46 with a properly functioning intestinal barrier. Patients with an altered gut barrier showed a significantly higher score in the Gastrointestinal Symptom Rating Scale (3.20 vs 1.46, p< 0.001). Moreover, patients with psoriasis and a disrupted intestinal barrier demonstrated a higher disease activity (PASI: 19.7 vs 10.3, p< 0.001) and systemic inflammatory parameters (neutrophil-to-lymphocyte ratio: 2.86 vs 1.71, p< 0.001; C-reactive protein 3.76 vs 1.92; p< 0.05). The marker of bacterial translocation was significantly higher in psoriatic patients with damaged gut integrity (TMAO: 375.7± 51.9 vs 119.4± 27.5 ng/mL; p< 0.05).Conclusion: The altered gut barrier in psoriasis is associated with gastrointestinal symptoms, systemic inflammatory profile and the increased blood concentration of gut microbiota-derived metabolite – TMAO. Intestinal barrier modulation represents a new promising therapeutic approach.Keywords: gut barrier, microbiome, psoriasis, systemic sclerosis, TMAO
format	article
author	Sikora M Stec A Chrabaszcz M Giebultowicz J Samborowska E Jazwiec R Dadlez M Olszewska M Rudnicka L
author_facet	Sikora M Stec A Chrabaszcz M Giebultowicz J Samborowska E Jazwiec R Dadlez M Olszewska M Rudnicka L
author_sort	Sikora M
title	Clinical Implications of Intestinal Barrier Damage in Psoriasis
title_short	Clinical Implications of Intestinal Barrier Damage in Psoriasis
title_full	Clinical Implications of Intestinal Barrier Damage in Psoriasis
title_fullStr	Clinical Implications of Intestinal Barrier Damage in Psoriasis
title_full_unstemmed	Clinical Implications of Intestinal Barrier Damage in Psoriasis
title_sort	clinical implications of intestinal barrier damage in psoriasis
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/109e863ee3de4425bdf43dd67cbb8eb5
work_keys_str_mv	AT sikoram clinicalimplicationsofintestinalbarrierdamageinpsoriasis AT steca clinicalimplicationsofintestinalbarrierdamageinpsoriasis AT chrabaszczm clinicalimplicationsofintestinalbarrierdamageinpsoriasis AT giebultowiczj clinicalimplicationsofintestinalbarrierdamageinpsoriasis AT samborowskae clinicalimplicationsofintestinalbarrierdamageinpsoriasis AT jazwiecr clinicalimplicationsofintestinalbarrierdamageinpsoriasis AT dadlezm clinicalimplicationsofintestinalbarrierdamageinpsoriasis AT olszewskam clinicalimplicationsofintestinalbarrierdamageinpsoriasis AT rudnickal clinicalimplicationsofintestinalbarrierdamageinpsoriasis
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Clinical Implications of Intestinal Barrier Damage in Psoriasis

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