Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study

Abstract Bullous pemphigoid (BP), the most frequent blistering dermatosis in the elderly, is associated with increased mortality. The severity of BP can be assessed by detecting the anti-BP180 immunoglobulin G (IgG) concentration, but the lab test is not available in many community clinics. BP patie...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Sijia Wang, Mei Lu, Zijun Zhao, Xueting Peng, Liang Li, Chuantao Cheng, Min Fang, Yumin Xia, Yale Liu
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/109f954b88fc439e9a814bfa7c885c6f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:109f954b88fc439e9a814bfa7c885c6f
record_format	dspace
spelling	oai:doaj.org-article:109f954b88fc439e9a814bfa7c885c6f2021-12-02T17:19:14ZPlasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study10.1038/s41598-021-97202-w2045-2322https://doaj.org/article/109f954b88fc439e9a814bfa7c885c6f2021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97202-whttps://doaj.org/toc/2045-2322Abstract Bullous pemphigoid (BP), the most frequent blistering dermatosis in the elderly, is associated with increased mortality. The severity of BP can be assessed by detecting the anti-BP180 immunoglobulin G (IgG) concentration, but the lab test is not available in many community clinics. BP patients are usually in a hypercoagulable state with increased levels of D-dimer and fibrin degradation products (FDPs). We aimed to evaluate the use of D-dimer and FDPs in assessing BP severity. We compared the levels of plasma D-dimer, plasma FDPs, eosinophil counts, eosinophil cationic protein, and serum anti-BP180 IgG concentration between 48 typical BP patients and 33 Herpes zoster (HZ) patients (control group). Correlational analyses were conducted to determine the relationships between the lab values and common BP severity markers. The plasma D-dimer and FDP levels were higher in BP patients than in HZ controls (D-dimer: 3297 ± 2517 µg/L vs. 569.70 ± 412.40 µg/L; FDP: 9.74 ± 5.88 mg/L vs. 2.02 ± 1.69 mg/L, respectively, P < 0.0001). Significant positive correlations were found between D-dimer/FDP levels and BP severity markers (i.e. anti-BP180 IgG concentration [D-dimer: r = 0.3928, P = 0.0058; FDP: r = 0.4379, P = 0.0019] and eosinophil counts [D-dimer: r = 0.3625, P = 0.0013; FDP: r = 0.2880, P = 0.0472]) in BP patients. We also found an association between FDP and urticaria/erythema lesions (r = 0.3016, P = 0.0372), but no other BPDAI components. In 19 BP patients with complete remission after systemic glucocorticoid treatment, D-dimer and FDP levels decreased post-therapy (D-dimer: 5559 ± 7492 µg/L vs. 1738 ± 1478 µg/L; P < 0.0001; FDP: 11.20 ± 5.88 mg/L vs. 5.13 ± 3.44 mg/L; P = 0.0003), whereas they did not in BP patients with treatment resistant. Plasma D-dimer and FDP are convenient markers to evaluate BP severity assistant on BPDAI and eosinophil counts. FDP is also helpful for inflammatory lesions in BP patients.Sijia WangMei LuZijun ZhaoXueting PengLiang LiChuantao ChengMin FangYumin XiaYale LiuNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sijia Wang Mei Lu Zijun Zhao Xueting Peng Liang Li Chuantao Cheng Min Fang Yumin Xia Yale Liu Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study
description	Abstract Bullous pemphigoid (BP), the most frequent blistering dermatosis in the elderly, is associated with increased mortality. The severity of BP can be assessed by detecting the anti-BP180 immunoglobulin G (IgG) concentration, but the lab test is not available in many community clinics. BP patients are usually in a hypercoagulable state with increased levels of D-dimer and fibrin degradation products (FDPs). We aimed to evaluate the use of D-dimer and FDPs in assessing BP severity. We compared the levels of plasma D-dimer, plasma FDPs, eosinophil counts, eosinophil cationic protein, and serum anti-BP180 IgG concentration between 48 typical BP patients and 33 Herpes zoster (HZ) patients (control group). Correlational analyses were conducted to determine the relationships between the lab values and common BP severity markers. The plasma D-dimer and FDP levels were higher in BP patients than in HZ controls (D-dimer: 3297 ± 2517 µg/L vs. 569.70 ± 412.40 µg/L; FDP: 9.74 ± 5.88 mg/L vs. 2.02 ± 1.69 mg/L, respectively, P < 0.0001). Significant positive correlations were found between D-dimer/FDP levels and BP severity markers (i.e. anti-BP180 IgG concentration [D-dimer: r = 0.3928, P = 0.0058; FDP: r = 0.4379, P = 0.0019] and eosinophil counts [D-dimer: r = 0.3625, P = 0.0013; FDP: r = 0.2880, P = 0.0472]) in BP patients. We also found an association between FDP and urticaria/erythema lesions (r = 0.3016, P = 0.0372), but no other BPDAI components. In 19 BP patients with complete remission after systemic glucocorticoid treatment, D-dimer and FDP levels decreased post-therapy (D-dimer: 5559 ± 7492 µg/L vs. 1738 ± 1478 µg/L; P < 0.0001; FDP: 11.20 ± 5.88 mg/L vs. 5.13 ± 3.44 mg/L; P = 0.0003), whereas they did not in BP patients with treatment resistant. Plasma D-dimer and FDP are convenient markers to evaluate BP severity assistant on BPDAI and eosinophil counts. FDP is also helpful for inflammatory lesions in BP patients.
format	article
author	Sijia Wang Mei Lu Zijun Zhao Xueting Peng Liang Li Chuantao Cheng Min Fang Yumin Xia Yale Liu
author_facet	Sijia Wang Mei Lu Zijun Zhao Xueting Peng Liang Li Chuantao Cheng Min Fang Yumin Xia Yale Liu
author_sort	Sijia Wang
title	Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study
title_short	Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study
title_full	Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study
title_fullStr	Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study
title_full_unstemmed	Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study
title_sort	plasma levels of d-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/109f954b88fc439e9a814bfa7c885c6f
work_keys_str_mv	AT sijiawang plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy AT meilu plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy AT zijunzhao plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy AT xuetingpeng plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy AT liangli plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy AT chuantaocheng plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy AT minfang plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy AT yuminxia plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy AT yaleliu plasmalevelsofddimerandfibrindegradationproductscorrelatewithbullouspemphigoidseverityacrosssectionalstudy
_version_	1718381067727011840

Plasma levels of D-dimer and fibrin degradation products correlate with bullous pemphigoid severity: a cross-sectional study

Ejemplares similares