Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort
Abstract Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom...
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Nature Portfolio
2021
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oai:doaj.org-article:10a254afe79640d29b0d02561b498bb02021-12-02T10:44:23ZLung microbiota associations with clinical features of COPD in the SPIROMICS cohort10.1038/s41522-021-00185-92055-5008https://doaj.org/article/10a254afe79640d29b0d02561b498bb02021-02-01T00:00:00Zhttps://doi.org/10.1038/s41522-021-00185-9https://doaj.org/toc/2055-5008Abstract Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom burden, and functional impairment). Using bronchoalveolar lavage fluid collected from 181 never-smokers and ever-smokers with or without COPD (GOLD 0-2) enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we find that lung bacterial composition associates with several clinical features, in particular bronchodilator responsiveness, peak expiratory flow rate, and forced expiratory flow rate between 25 and 75% of FVC (FEF25–75). Measures of symptom burden (COPD Assessment Test) and functional impairment (six-minute walk distance) also associate with disparate lung microbiota composition. Drivers of these relationships include members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. Thus, lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD.Kristopher OpronLesa A. BegleyJohn R. Erb-DownwardChristine FreemanSiddharth MadapoosiNeil E. AlexisIgor BarjaktarevicR. Graham BarrEugene R. BleeckerRussell P. BowlerStephanie A. ChristensonAlejandro P. ComellasChristopher B. CooperDavid J. CouperClaire M. DoerschukMark T. DransfieldMeiLan K. HanNadia N. HanselAnnette T. HastieEric A. HoffmanRobert J. KanerJerry KrishnanWanda K. O’NealVictor E. OrtegaRobert PaineStephen P. PetersJ. Michael WellsPrescott G. WoodruffFernando J. MartinezJeffrey L. CurtisGary B. HuffnagleYvonne J. HuangNature PortfolioarticleMicrobial ecologyQR100-130ENnpj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-10 (2021) |
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DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Microbial ecology QR100-130 |
| spellingShingle |
Microbial ecology QR100-130 Kristopher Opron Lesa A. Begley John R. Erb-Downward Christine Freeman Siddharth Madapoosi Neil E. Alexis Igor Barjaktarevic R. Graham Barr Eugene R. Bleecker Russell P. Bowler Stephanie A. Christenson Alejandro P. Comellas Christopher B. Cooper David J. Couper Claire M. Doerschuk Mark T. Dransfield MeiLan K. Han Nadia N. Hansel Annette T. Hastie Eric A. Hoffman Robert J. Kaner Jerry Krishnan Wanda K. O’Neal Victor E. Ortega Robert Paine Stephen P. Peters J. Michael Wells Prescott G. Woodruff Fernando J. Martinez Jeffrey L. Curtis Gary B. Huffnagle Yvonne J. Huang Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| description |
Abstract Chronic obstructive pulmonary disease (COPD) is heterogeneous in development, progression, and phenotypes. Little is known about the lung microbiome, sampled by bronchoscopy, in milder COPD and its relationships to clinical features that reflect disease heterogeneity (lung function, symptom burden, and functional impairment). Using bronchoalveolar lavage fluid collected from 181 never-smokers and ever-smokers with or without COPD (GOLD 0-2) enrolled in the SubPopulations and InteRmediate Outcome Measures In COPD Study (SPIROMICS), we find that lung bacterial composition associates with several clinical features, in particular bronchodilator responsiveness, peak expiratory flow rate, and forced expiratory flow rate between 25 and 75% of FVC (FEF25–75). Measures of symptom burden (COPD Assessment Test) and functional impairment (six-minute walk distance) also associate with disparate lung microbiota composition. Drivers of these relationships include members of the Streptococcus, Prevotella, Veillonella, Staphylococcus, and Pseudomonas genera. Thus, lung microbiota differences may contribute to airway dysfunction and airway disease in milder COPD. |
| format |
article |
| author |
Kristopher Opron Lesa A. Begley John R. Erb-Downward Christine Freeman Siddharth Madapoosi Neil E. Alexis Igor Barjaktarevic R. Graham Barr Eugene R. Bleecker Russell P. Bowler Stephanie A. Christenson Alejandro P. Comellas Christopher B. Cooper David J. Couper Claire M. Doerschuk Mark T. Dransfield MeiLan K. Han Nadia N. Hansel Annette T. Hastie Eric A. Hoffman Robert J. Kaner Jerry Krishnan Wanda K. O’Neal Victor E. Ortega Robert Paine Stephen P. Peters J. Michael Wells Prescott G. Woodruff Fernando J. Martinez Jeffrey L. Curtis Gary B. Huffnagle Yvonne J. Huang |
| author_facet |
Kristopher Opron Lesa A. Begley John R. Erb-Downward Christine Freeman Siddharth Madapoosi Neil E. Alexis Igor Barjaktarevic R. Graham Barr Eugene R. Bleecker Russell P. Bowler Stephanie A. Christenson Alejandro P. Comellas Christopher B. Cooper David J. Couper Claire M. Doerschuk Mark T. Dransfield MeiLan K. Han Nadia N. Hansel Annette T. Hastie Eric A. Hoffman Robert J. Kaner Jerry Krishnan Wanda K. O’Neal Victor E. Ortega Robert Paine Stephen P. Peters J. Michael Wells Prescott G. Woodruff Fernando J. Martinez Jeffrey L. Curtis Gary B. Huffnagle Yvonne J. Huang |
| author_sort |
Kristopher Opron |
| title |
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_short |
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_full |
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_fullStr |
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_full_unstemmed |
Lung microbiota associations with clinical features of COPD in the SPIROMICS cohort |
| title_sort |
lung microbiota associations with clinical features of copd in the spiromics cohort |
| publisher |
Nature Portfolio |
| publishDate |
2021 |
| url |
https://doaj.org/article/10a254afe79640d29b0d02561b498bb0 |
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