The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma

The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma

Kenji Nakamoto,1 Masahiko Takeshi,2 Toshihiko Hiraoka,2,3 Mayuko Eguchi,2,4 Yuichiro Nakano,1,2 Naomi Otsuka,5 Hiroko Hizaki,5 Hiromi Akai,5 Masayo Hashimoto5 1Department of Ophthalmology, Nippon Medical School, Tokyo, Japan; 2Shinanozaka Clinic, Tokyo, Japan; 3Hiraoka Eye Clinic, Saitama, Japan; 4...

Descripción completa

Guardado en:
Detalles Bibliográficos
Autores principales: Nakamoto K, Takeshi M, Hiraoka T, Eguchi M, Nakano Y, Otsuka N, Hizaki H, Akai H, Hashimoto M
Formato: article
Lenguaje:EN
Publicado: Dove Medical Press 2018
Materias:
Intraocular pressure / Tafluprost / Circadian IOP/ 24-hour IOP/ timolol gel
Ophthalmology
RE1-994
Acceso en línea:https://doaj.org/article/10a685e80a224ee1b55462122e803c27
Etiquetas: Agregar Etiqueta
Sin Etiquetas, Sea el primero en etiquetar este registro!
id oai:doaj.org-article:10a685e80a224ee1b55462122e803c27
record_format dspace
spelling oai:doaj.org-article:10a685e80a224ee1b55462122e803c272021-12-02T05:19:27ZThe 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma1177-5483https://doaj.org/article/10a685e80a224ee1b55462122e803c272018-02-01T00:00:00Zhttps://www.dovepress.com/the-24-hour-intraocular-pressure-control-by-tafluprosttimolol-fixed-co-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Kenji Nakamoto,1 Masahiko Takeshi,2 Toshihiko Hiraoka,2,3 Mayuko Eguchi,2,4 Yuichiro Nakano,1,2 Naomi Otsuka,5 Hiroko Hizaki,5 Hiromi Akai,5 Masayo Hashimoto5 1Department of Ophthalmology, Nippon Medical School, Tokyo, Japan; 2Shinanozaka Clinic, Tokyo, Japan; 3Hiraoka Eye Clinic, Saitama, Japan; 4Musashiurawa Eye Clinic, Saitama, Japan; 5Japan Medical Affairs, Global R&D, Santen Pharmaceutical Co., Ltd., Osaka, Japan Objective: The aim of this study was to evaluate the 24-hour intraocular pressure (IOP)-control effect of the tafluprost/timolol fixed combination (TAF/TIM-FC) in patients with primary open-angle glaucoma after they switched from the concomitant use of tafluprost and timolol gel-forming solution. Patients and methods: Twenty patients with primary open-angle glaucoma (12 male and 8 female; mean ± SD age, 57.0±7.1 years) were included in this study. The patients were treated for 8 weeks with the concomitant administration of tafluprost and timolol gel-forming solution (evening dosing). At the end of this period, the patients underwent 24-hour IOP monitoring (measured at 21:00, 01:00, 05:00, 09:00, 13:00 and 17:00). IOP was measured with Goldmann applanation tonometer (GAT) and Icare PRO at sitting position at all timepoints and additionally, at supine position with Icare PRO tonometer at 01:00 and 05:00. The patients were then all switched to TAF/TIM-FC treatment (evening dosing). After 8 weeks, the 24-hour IOP monitoring was repeated. Results: Nineteen patients completed the study. The mean 24-hour IOPs in the concomitant and TAF/TIM-FC phases were 13.8±2.7 vs 13.3±2.8 mmHg (P=0.0033) with the GAT in the sitting position and 13.96±2.56 vs 13.48±2.56 mmHg (P=0.0120) with the Icare PRO in habitual positions. In comparison with the concomitant phase, significantly lower IOP was observed for the TAF/TIM-FC phase at 21:00 and 01:00 with the GAT and at 01:00 with the Icare PRO. In addition, the maximum IOP and fluctuations in IOP in habitual positions were lower for the TAF/TIM-FC phase than for the concomitant phase. Conclusion: TAF/TIM-FC showed a stable 24-hour IOP-lowering effect and was equally or more effective than the concomitant use of tafluprost and timolol gel, both when sitting and when in habitual positions. Keywords: intraocular pressure, tafluprost, circadian IOP, 24-hour IOP, timolol gelNakamoto KTakeshi MHiraoka TEguchi MNakano YOtsuka NHizaki HAkai HHashimoto MDove Medical PressarticleIntraocular pressure / Tafluprost / Circadian IOP/ 24-hour IOP/ timolol gelOphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 12, Pp 359-367 (2018)
institution DOAJ
collection DOAJ
language EN
topic Intraocular pressure / Tafluprost / Circadian IOP/ 24-hour IOP/ timolol gel
Ophthalmology
RE1-994
spellingShingle Intraocular pressure / Tafluprost / Circadian IOP/ 24-hour IOP/ timolol gel
Ophthalmology
RE1-994
Nakamoto K
Takeshi M
Hiraoka T
Eguchi M
Nakano Y
Otsuka N
Hizaki H
Akai H
Hashimoto M
The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma
description Kenji Nakamoto,1 Masahiko Takeshi,2 Toshihiko Hiraoka,2,3 Mayuko Eguchi,2,4 Yuichiro Nakano,1,2 Naomi Otsuka,5 Hiroko Hizaki,5 Hiromi Akai,5 Masayo Hashimoto5 1Department of Ophthalmology, Nippon Medical School, Tokyo, Japan; 2Shinanozaka Clinic, Tokyo, Japan; 3Hiraoka Eye Clinic, Saitama, Japan; 4Musashiurawa Eye Clinic, Saitama, Japan; 5Japan Medical Affairs, Global R&D, Santen Pharmaceutical Co., Ltd., Osaka, Japan Objective: The aim of this study was to evaluate the 24-hour intraocular pressure (IOP)-control effect of the tafluprost/timolol fixed combination (TAF/TIM-FC) in patients with primary open-angle glaucoma after they switched from the concomitant use of tafluprost and timolol gel-forming solution. Patients and methods: Twenty patients with primary open-angle glaucoma (12 male and 8 female; mean ± SD age, 57.0±7.1 years) were included in this study. The patients were treated for 8 weeks with the concomitant administration of tafluprost and timolol gel-forming solution (evening dosing). At the end of this period, the patients underwent 24-hour IOP monitoring (measured at 21:00, 01:00, 05:00, 09:00, 13:00 and 17:00). IOP was measured with Goldmann applanation tonometer (GAT) and Icare PRO at sitting position at all timepoints and additionally, at supine position with Icare PRO tonometer at 01:00 and 05:00. The patients were then all switched to TAF/TIM-FC treatment (evening dosing). After 8 weeks, the 24-hour IOP monitoring was repeated. Results: Nineteen patients completed the study. The mean 24-hour IOPs in the concomitant and TAF/TIM-FC phases were 13.8±2.7 vs 13.3±2.8 mmHg (P=0.0033) with the GAT in the sitting position and 13.96±2.56 vs 13.48±2.56 mmHg (P=0.0120) with the Icare PRO in habitual positions. In comparison with the concomitant phase, significantly lower IOP was observed for the TAF/TIM-FC phase at 21:00 and 01:00 with the GAT and at 01:00 with the Icare PRO. In addition, the maximum IOP and fluctuations in IOP in habitual positions were lower for the TAF/TIM-FC phase than for the concomitant phase. Conclusion: TAF/TIM-FC showed a stable 24-hour IOP-lowering effect and was equally or more effective than the concomitant use of tafluprost and timolol gel, both when sitting and when in habitual positions. Keywords: intraocular pressure, tafluprost, circadian IOP, 24-hour IOP, timolol gel
format article
author Nakamoto K
Takeshi M
Hiraoka T
Eguchi M
Nakano Y
Otsuka N
Hizaki H
Akai H
Hashimoto M
author_facet Nakamoto K
Takeshi M
Hiraoka T
Eguchi M
Nakano Y
Otsuka N
Hizaki H
Akai H
Hashimoto M
author_sort Nakamoto K
title The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma
title_short The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma
title_full The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma
title_fullStr The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma
title_full_unstemmed The 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma
title_sort 24-hour intraocular pressure control by tafluprost/timolol fixed combination after switching from the concomitant use of tafluprost and timolol gel-forming solution, in patients with primary open-angle glaucoma
publisher Dove Medical Press
publishDate 2018
url https://doaj.org/article/10a685e80a224ee1b55462122e803c27
work_keys_str_mv AT nakamotok the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT takeshim the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT hiraokat the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT eguchim the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT nakanoy the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT otsukan the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT hizakih the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT akaih the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT hashimotom the24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT nakamotok 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT takeshim 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT hiraokat 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT eguchim 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT nakanoy 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT otsukan 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT hizakih 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT akaih 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
AT hashimotom 24hourintraocularpressurecontrolbytafluprosttimololfixedcombinationafterswitchingfromtheconcomitantuseoftafluprostandtimololgelformingsolutioninpatientswithprimaryopenangleglaucoma
_version_ 1718400455577436160

Ejemplares similares