mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

Inhibitors of the mTORC1 pathway are considered anti-cancer drugs. Here, the authors show that on nutrient restriction, glutaminolysis-induced activation of mTORC1 induces apoptosis via inhibiting autophagy, highlighting that under such conditions inhibition of mTORC1 results in survival of cancer c...

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Auteurs principaux:	Victor H. Villar, Tra Ly Nguyen, Vanessa Delcroix, Silvia Terés, Marion Bouchecareilh, Bénédicte Salin, Clément Bodineau, Pierre Vacher, Muriel Priault, Pierre Soubeyran, Raúl V. Durán
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2017
Sujets:	Science Q
Accès en ligne:	https://doaj.org/article/10a70e280d43468aa959ed6e6598adf2
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spelling	oai:doaj.org-article:10a70e280d43468aa959ed6e6598adf22021-12-02T14:42:17ZmTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation10.1038/ncomms141242041-1723https://doaj.org/article/10a70e280d43468aa959ed6e6598adf22017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms14124https://doaj.org/toc/2041-1723Inhibitors of the mTORC1 pathway are considered anti-cancer drugs. Here, the authors show that on nutrient restriction, glutaminolysis-induced activation of mTORC1 induces apoptosis via inhibiting autophagy, highlighting that under such conditions inhibition of mTORC1 results in survival of cancer cells.Victor H. VillarTra Ly NguyenVanessa DelcroixSilvia TerésMarion BouchecareilhBénédicte SalinClément BodineauPierre VacherMuriel PriaultPierre SoubeyranRaúl V. DuránNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Victor H. Villar Tra Ly Nguyen Vanessa Delcroix Silvia Terés Marion Bouchecareilh Bénédicte Salin Clément Bodineau Pierre Vacher Muriel Priault Pierre Soubeyran Raúl V. Durán mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
description	Inhibitors of the mTORC1 pathway are considered anti-cancer drugs. Here, the authors show that on nutrient restriction, glutaminolysis-induced activation of mTORC1 induces apoptosis via inhibiting autophagy, highlighting that under such conditions inhibition of mTORC1 results in survival of cancer cells.
format	article
author	Victor H. Villar Tra Ly Nguyen Vanessa Delcroix Silvia Terés Marion Bouchecareilh Bénédicte Salin Clément Bodineau Pierre Vacher Muriel Priault Pierre Soubeyran Raúl V. Durán
author_facet	Victor H. Villar Tra Ly Nguyen Vanessa Delcroix Silvia Terés Marion Bouchecareilh Bénédicte Salin Clément Bodineau Pierre Vacher Muriel Priault Pierre Soubeyran Raúl V. Durán
author_sort	Victor H. Villar
title	mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
title_short	mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
title_full	mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
title_fullStr	mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
title_full_unstemmed	mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
title_sort	mtorc1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/10a70e280d43468aa959ed6e6598adf2
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mTORC1 inhibition in cancer cells protects from glutaminolysis-mediated apoptosis during nutrient limitation

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