Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes

Background: Asthma is a heterogeneous disease with distinct prevalence and manifestation between sexes. This study was to identify sex-specific features of asthma via metabolomic analysis of sphingolipids. Methods: Forty-two asthma patients (27 women and 15 men) admitted to the Peking University Thi...

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Autores principales:	Zhu Song, Wei Yan, Mairipaiti Abulikemu, Juan Wang, Yan Xing, Qingtao Zhou, Shaohua Ma, Chun Chang
Formato:	article
Lenguaje:	EN
Publicado:	KeAi Communications Co., Ltd. 2021
Materias:	Asthma Inflammation Sphingolipids Sex characteristics Testosterone Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/10a7fe140896436da05c6080bdd0206e
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spelling	oai:doaj.org-article:10a7fe140896436da05c6080bdd0206e2021-12-02T18:46:02ZSphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes2095-882X10.1016/j.cdtm.2021.04.002https://doaj.org/article/10a7fe140896436da05c6080bdd0206e2021-09-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S2095882X21000268https://doaj.org/toc/2095-882XBackground: Asthma is a heterogeneous disease with distinct prevalence and manifestation between sexes. This study was to identify sex-specific features of asthma via metabolomic analysis of sphingolipids. Methods: Forty-two asthma patients (27 women and 15 men) admitted to the Peking University Third Hospital from January 2015 to December 2015 were enrolled. Peripheral venous blood was collected for metabolomic analysis by targeted liquid chromatography-mass spectrometry. Sex hormones(estradiol, progesterone, testosterone, and androstenedione) and multiple inflammatory factors (periostin, leptin, IgE, IL-4, IL-5, IL-10, IL-13, IL-17A, and IFN-γ) were also assessed. The eosinophil percentage in induced sputum was also detected. All these data were applied to comparative analysis between sexes. Results: Testosterone was negatively related to periostin (ρ = −0.420, P = 0.009) and IL-5 (ρ = −0.540, P = 0.012), while estradiol was positively related to the blood eosinophil percentage (ρ = 0.384, P = 0.025). Among the eighteen species of sphingolipids detected in the 42 patients, five ceramide (Cer) species (Cer16:0, Cer:20:0, Cer22:0, Cer24:0, and Cer26:0) and one sphingomyelin (SM) species (SM38:0) were significantly higher in male than in female patients. Further investigation found that the correlation between Cer20:0 and IL-5 was positive in males (ρ = 0.943, P = 0.005) but negative in females (ρ = −0.561, P = 0.030). Conclusions: Testosterone was negatively correlated with eosinophil inflammatory factors, but estradiol was positively correlated. Male asthma patients had higher ceramide and sphingomyelin levels than female patients. Different sexes had opposite correlations with ceramide and IL-5, respectively, suggesting that therapeutic strategies targeting ceramide should be different between sexes.Zhu SongWei YanMairipaiti AbulikemuJuan WangYan XingQingtao ZhouShaohua MaChun ChangKeAi Communications Co., Ltd.articleAsthmaInflammationSphingolipidsSex characteristicsTestosteroneMedicine (General)R5-920ENChronic Diseases and Translational Medicine, Vol 7, Iss 3, Pp 199-205 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Asthma Inflammation Sphingolipids Sex characteristics Testosterone Medicine (General) R5-920
spellingShingle	Asthma Inflammation Sphingolipids Sex characteristics Testosterone Medicine (General) R5-920 Zhu Song Wei Yan Mairipaiti Abulikemu Juan Wang Yan Xing Qingtao Zhou Shaohua Ma Chun Chang Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes
description	Background: Asthma is a heterogeneous disease with distinct prevalence and manifestation between sexes. This study was to identify sex-specific features of asthma via metabolomic analysis of sphingolipids. Methods: Forty-two asthma patients (27 women and 15 men) admitted to the Peking University Third Hospital from January 2015 to December 2015 were enrolled. Peripheral venous blood was collected for metabolomic analysis by targeted liquid chromatography-mass spectrometry. Sex hormones(estradiol, progesterone, testosterone, and androstenedione) and multiple inflammatory factors (periostin, leptin, IgE, IL-4, IL-5, IL-10, IL-13, IL-17A, and IFN-γ) were also assessed. The eosinophil percentage in induced sputum was also detected. All these data were applied to comparative analysis between sexes. Results: Testosterone was negatively related to periostin (ρ = −0.420, P = 0.009) and IL-5 (ρ = −0.540, P = 0.012), while estradiol was positively related to the blood eosinophil percentage (ρ = 0.384, P = 0.025). Among the eighteen species of sphingolipids detected in the 42 patients, five ceramide (Cer) species (Cer16:0, Cer:20:0, Cer22:0, Cer24:0, and Cer26:0) and one sphingomyelin (SM) species (SM38:0) were significantly higher in male than in female patients. Further investigation found that the correlation between Cer20:0 and IL-5 was positive in males (ρ = 0.943, P = 0.005) but negative in females (ρ = −0.561, P = 0.030). Conclusions: Testosterone was negatively correlated with eosinophil inflammatory factors, but estradiol was positively correlated. Male asthma patients had higher ceramide and sphingomyelin levels than female patients. Different sexes had opposite correlations with ceramide and IL-5, respectively, suggesting that therapeutic strategies targeting ceramide should be different between sexes.
format	article
author	Zhu Song Wei Yan Mairipaiti Abulikemu Juan Wang Yan Xing Qingtao Zhou Shaohua Ma Chun Chang
author_facet	Zhu Song Wei Yan Mairipaiti Abulikemu Juan Wang Yan Xing Qingtao Zhou Shaohua Ma Chun Chang
author_sort	Zhu Song
title	Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes
title_short	Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes
title_full	Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes
title_fullStr	Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes
title_full_unstemmed	Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes
title_sort	sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes
publisher	KeAi Communications Co., Ltd.
publishDate	2021
url	https://doaj.org/article/10a7fe140896436da05c6080bdd0206e
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Sphingolipid profiles and their relationship with inflammatory factors in asthmatic patients of different sexes

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