BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis

B-cell development is tightly regulated by transcription programs that are coordinated by transcription factors (TF) and locus accessibility. Here the authors show that, in mice and humans, the epigenetic reader BRWD1 inhibits and promotes the accessibility of enhancers for early and late B lymphopo...

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Autores principales:	Malay Mandal, Mark Maienschein-Cline, Patrick Maffucci, Margaret Veselits, Domenick E. Kennedy, Kaitlin C. McLean, Michael K. Okoreeh, Sophiya Karki, Charlotte Cunningham-Rundles, Marcus R. Clark
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10a9afe2f2c54ac6a4efed93ee1de7fb
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spelling	oai:doaj.org-article:10a9afe2f2c54ac6a4efed93ee1de7fb2021-12-02T16:56:44ZBRWD1 orchestrates epigenetic landscape of late B lymphopoiesis10.1038/s41467-018-06165-62041-1723https://doaj.org/article/10a9afe2f2c54ac6a4efed93ee1de7fb2018-09-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-06165-6https://doaj.org/toc/2041-1723B-cell development is tightly regulated by transcription programs that are coordinated by transcription factors (TF) and locus accessibility. Here the authors show that, in mice and humans, the epigenetic reader BRWD1 inhibits and promotes the accessibility of enhancers for early and late B lymphopoiesis, respectively.Malay MandalMark Maienschein-ClinePatrick MaffucciMargaret VeselitsDomenick E. KennedyKaitlin C. McLeanMichael K. OkoreehSophiya KarkiCharlotte Cunningham-RundlesMarcus R. ClarkNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Malay Mandal Mark Maienschein-Cline Patrick Maffucci Margaret Veselits Domenick E. Kennedy Kaitlin C. McLean Michael K. Okoreeh Sophiya Karki Charlotte Cunningham-Rundles Marcus R. Clark BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
description	B-cell development is tightly regulated by transcription programs that are coordinated by transcription factors (TF) and locus accessibility. Here the authors show that, in mice and humans, the epigenetic reader BRWD1 inhibits and promotes the accessibility of enhancers for early and late B lymphopoiesis, respectively.
format	article
author	Malay Mandal Mark Maienschein-Cline Patrick Maffucci Margaret Veselits Domenick E. Kennedy Kaitlin C. McLean Michael K. Okoreeh Sophiya Karki Charlotte Cunningham-Rundles Marcus R. Clark
author_facet	Malay Mandal Mark Maienschein-Cline Patrick Maffucci Margaret Veselits Domenick E. Kennedy Kaitlin C. McLean Michael K. Okoreeh Sophiya Karki Charlotte Cunningham-Rundles Marcus R. Clark
author_sort	Malay Mandal
title	BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
title_short	BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
title_full	BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
title_fullStr	BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
title_full_unstemmed	BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis
title_sort	brwd1 orchestrates epigenetic landscape of late b lymphopoiesis
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/10a9afe2f2c54ac6a4efed93ee1de7fb
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BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis

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