BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis

BRWD1 orchestrates epigenetic landscape of late B lymphopoiesis

B-cell development is tightly regulated by transcription programs that are coordinated by transcription factors (TF) and locus accessibility. Here the authors show that, in mice and humans, the epigenetic reader BRWD1 inhibits and promotes the accessibility of enhancers for early and late B lymphopo...

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Autores principales: Malay Mandal, Mark Maienschein-Cline, Patrick Maffucci, Margaret Veselits, Domenick E. Kennedy, Kaitlin C. McLean, Michael K. Okoreeh, Sophiya Karki, Charlotte Cunningham-Rundles, Marcus R. Clark
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Science
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Acceso en línea:https://doaj.org/article/10a9afe2f2c54ac6a4efed93ee1de7fb
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