Associations between dog keeping and indoor dust microbiota

Abstract Living with dogs appears to protect against allergic diseases and airway infections, an effect possibly linked with immunomodulation by microbial exposures associated with dogs. The aim of this study was to characterize the influence of dog ownership on house dust microbiota composition. Th...

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Autores principales:	Jenni M. Mäki, Pirkka V. Kirjavainen, Martin Täubel, Eija Piippo-Savolainen, Katri Backman, Anne Hyvärinen, Pauli Tuoresmäki, Balamuralikrishna Jayaprakash, Joachim Heinrich, Gunda Herberth, Marie Standl, Juha Pekkanen, Anne M. Karvonen
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10acb69b3c4d412b8741086c7218aa4f
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spelling	oai:doaj.org-article:10acb69b3c4d412b8741086c7218aa4f2021-12-02T13:34:58ZAssociations between dog keeping and indoor dust microbiota10.1038/s41598-021-84790-w2045-2322https://doaj.org/article/10acb69b3c4d412b8741086c7218aa4f2021-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-84790-whttps://doaj.org/toc/2045-2322Abstract Living with dogs appears to protect against allergic diseases and airway infections, an effect possibly linked with immunomodulation by microbial exposures associated with dogs. The aim of this study was to characterize the influence of dog ownership on house dust microbiota composition. The bacterial and fungal microbiota was characterized with Illumina MiSeq sequencing from floor dust samples collected from homes in a Finnish rural-suburban (LUKAS2, N = 182) birth cohort, and the results were replicated in a German urban (LISA, N = 284) birth cohort. Human associated bacteria variable was created by summing up the relative abundances of five bacterial taxa. Bacterial richness, Shannon index and the relative abundances of seven bacterial genera, mostly within the phyla Proteobacteria and Firmicutes, were significantly higher in the dog than in the non-dog homes, whereas the relative abundance of human associated bacteria was lower. The results were largely replicated in LISA. Fungal microbiota richness and abundance of Leucosporidiella genus were higher in dog homes in LUKAS2 and the latter association replicated in LISA. Our study confirms that dog ownership is reproducibly associated with increased bacterial richness and diversity in house dust and identifies specific dog ownership-associated genera. Dogs appeared to have more limited influence on the fungal than bacterial indoor microbiota.Jenni M. MäkiPirkka V. KirjavainenMartin TäubelEija Piippo-SavolainenKatri BackmanAnne HyvärinenPauli TuoresmäkiBalamuralikrishna JayaprakashJoachim HeinrichGunda HerberthMarie StandlJuha PekkanenAnne M. KarvonenNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Jenni M. Mäki Pirkka V. Kirjavainen Martin Täubel Eija Piippo-Savolainen Katri Backman Anne Hyvärinen Pauli Tuoresmäki Balamuralikrishna Jayaprakash Joachim Heinrich Gunda Herberth Marie Standl Juha Pekkanen Anne M. Karvonen Associations between dog keeping and indoor dust microbiota
description	Abstract Living with dogs appears to protect against allergic diseases and airway infections, an effect possibly linked with immunomodulation by microbial exposures associated with dogs. The aim of this study was to characterize the influence of dog ownership on house dust microbiota composition. The bacterial and fungal microbiota was characterized with Illumina MiSeq sequencing from floor dust samples collected from homes in a Finnish rural-suburban (LUKAS2, N = 182) birth cohort, and the results were replicated in a German urban (LISA, N = 284) birth cohort. Human associated bacteria variable was created by summing up the relative abundances of five bacterial taxa. Bacterial richness, Shannon index and the relative abundances of seven bacterial genera, mostly within the phyla Proteobacteria and Firmicutes, were significantly higher in the dog than in the non-dog homes, whereas the relative abundance of human associated bacteria was lower. The results were largely replicated in LISA. Fungal microbiota richness and abundance of Leucosporidiella genus were higher in dog homes in LUKAS2 and the latter association replicated in LISA. Our study confirms that dog ownership is reproducibly associated with increased bacterial richness and diversity in house dust and identifies specific dog ownership-associated genera. Dogs appeared to have more limited influence on the fungal than bacterial indoor microbiota.
format	article
author	Jenni M. Mäki Pirkka V. Kirjavainen Martin Täubel Eija Piippo-Savolainen Katri Backman Anne Hyvärinen Pauli Tuoresmäki Balamuralikrishna Jayaprakash Joachim Heinrich Gunda Herberth Marie Standl Juha Pekkanen Anne M. Karvonen
author_facet	Jenni M. Mäki Pirkka V. Kirjavainen Martin Täubel Eija Piippo-Savolainen Katri Backman Anne Hyvärinen Pauli Tuoresmäki Balamuralikrishna Jayaprakash Joachim Heinrich Gunda Herberth Marie Standl Juha Pekkanen Anne M. Karvonen
author_sort	Jenni M. Mäki
title	Associations between dog keeping and indoor dust microbiota
title_short	Associations between dog keeping and indoor dust microbiota
title_full	Associations between dog keeping and indoor dust microbiota
title_fullStr	Associations between dog keeping and indoor dust microbiota
title_full_unstemmed	Associations between dog keeping and indoor dust microbiota
title_sort	associations between dog keeping and indoor dust microbiota
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10acb69b3c4d412b8741086c7218aa4f
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Associations between dog keeping and indoor dust microbiota

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