Population-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease

Background. Obesity is a barrier to transplant, reducing access and leading to worse outcomes versus nonobese adults. Most transplant centers in the United States maintain body mass index (BMI) cutoffs to listing for kidney transplantation of 35 to 40 kg/m2. There is little contemporary data on the...

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Autores principales:	Glenn K. Wakam, MD, Kyle H. Sheetz, MD, MS, Laura Gerhardinger, MA, John R. Montgomery, MD, Seth A. Waits, MD
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer 2021
Materias:	Surgery RD1-811
Acceso en línea:	https://doaj.org/article/10ad4e6e95bf40c78d66ba1645650ae6
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spelling	oai:doaj.org-article:10ad4e6e95bf40c78d66ba1645650ae62021-11-25T07:59:57ZPopulation-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease2373-873110.1097/TXD.0000000000001163https://doaj.org/article/10ad4e6e95bf40c78d66ba1645650ae62021-12-01T00:00:00Zhttp://journals.lww.com/transplantationdirect/fulltext/10.1097/TXD.0000000000001163https://doaj.org/toc/2373-8731Background. Obesity is a barrier to transplant, reducing access and leading to worse outcomes versus nonobese adults. Most transplant centers in the United States maintain body mass index (BMI) cutoffs to listing for kidney transplantation of 35 to 40 kg/m2. There is little contemporary data on the prevalence of obesity among patients with end-stage kidney disease (ESKD) despite its impact on clinical outcomes and healthcare expenditures. Methods. We utilized data from the US Renal Data System from 2008 to 2016 to identify a prevalent cohort of 1 079 410 patients with ESKD. Linear regression determined trends in the proportion of patients within each category of BMI. We also evaluated geographic variation in rates of obesity and transplantation across the United States. Results. Among the 1 079 410 ESKD patients, the largest cohort of patients were those with obesity (n = 423 270; 39.2%). There were 309 707 (28.7%) patients with an overweight BMI and 274 683 (25.4%) with a normal BMI. The proportion of patients with obesity increased significantly from 36.8% in 2008 to 40.2% in 2016 (trend 0.28; 95% confidence interval, 0.05-0.51). There was significant geographic variation by state with rates of obesity ranging from 32.3% to 45.4% and state transplant rates among those obese patients ranging from 22.5% to 46.8%. There is a weak correlation between states with increased rates of obese ESKD patients and states with an increased obesity transplant rate as indicated with r = 0.40 (P = 0.003). Conclusions. Beneficiaries with obesity are now the largest and fastest growing demographic among patients with ESKD in the United States.Glenn K. Wakam, MDKyle H. Sheetz, MD, MSLaura Gerhardinger, MAJohn R. Montgomery, MDSeth A. Waits, MDWolters KluwerarticleSurgeryRD1-811ENTransplantation Direct, Vol 7, Iss 12, p e787 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Surgery RD1-811
spellingShingle	Surgery RD1-811 Glenn K. Wakam, MD Kyle H. Sheetz, MD, MS Laura Gerhardinger, MA John R. Montgomery, MD Seth A. Waits, MD Population-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease
description	Background. Obesity is a barrier to transplant, reducing access and leading to worse outcomes versus nonobese adults. Most transplant centers in the United States maintain body mass index (BMI) cutoffs to listing for kidney transplantation of 35 to 40 kg/m2. There is little contemporary data on the prevalence of obesity among patients with end-stage kidney disease (ESKD) despite its impact on clinical outcomes and healthcare expenditures. Methods. We utilized data from the US Renal Data System from 2008 to 2016 to identify a prevalent cohort of 1 079 410 patients with ESKD. Linear regression determined trends in the proportion of patients within each category of BMI. We also evaluated geographic variation in rates of obesity and transplantation across the United States. Results. Among the 1 079 410 ESKD patients, the largest cohort of patients were those with obesity (n = 423 270; 39.2%). There were 309 707 (28.7%) patients with an overweight BMI and 274 683 (25.4%) with a normal BMI. The proportion of patients with obesity increased significantly from 36.8% in 2008 to 40.2% in 2016 (trend 0.28; 95% confidence interval, 0.05-0.51). There was significant geographic variation by state with rates of obesity ranging from 32.3% to 45.4% and state transplant rates among those obese patients ranging from 22.5% to 46.8%. There is a weak correlation between states with increased rates of obese ESKD patients and states with an increased obesity transplant rate as indicated with r = 0.40 (P = 0.003). Conclusions. Beneficiaries with obesity are now the largest and fastest growing demographic among patients with ESKD in the United States.
format	article
author	Glenn K. Wakam, MD Kyle H. Sheetz, MD, MS Laura Gerhardinger, MA John R. Montgomery, MD Seth A. Waits, MD
author_facet	Glenn K. Wakam, MD Kyle H. Sheetz, MD, MS Laura Gerhardinger, MA John R. Montgomery, MD Seth A. Waits, MD
author_sort	Glenn K. Wakam, MD
title	Population-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease
title_short	Population-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease
title_full	Population-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease
title_fullStr	Population-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease
title_full_unstemmed	Population-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease
title_sort	population-based trends in obesity and kidney transplantation among patients with end-stage kidney disease
publisher	Wolters Kluwer
publishDate	2021
url	https://doaj.org/article/10ad4e6e95bf40c78d66ba1645650ae6
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Population-based Trends in Obesity and Kidney Transplantation Among Patients With End-stage Kidney Disease

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