Intranasal administration of the chemotherapeutic perillyl alcohol results in selective delivery to the cerebrospinal fluid in rats

Abstract Perillyl alcohol (POH) has been extensively studied for the treatment of peripheral and primary brain tumors. The intranasal route of administration has been preferred for dosing POH in early-stage clinical trials associated with promising outcomes in primary brain cancer. However, it is un...

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Autores principales: Geetika Nehra, Shannon Andrews, Joan Rettig, Michael N. Gould, Jill D. Haag, Steven P. Howard, Robert G. Thorne
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/10ae0b670c5e46fc889e1453f7c66a14
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