Controlling for background genetic effects using polygenic scores improves the power of genome-wide association studies

Abstract Ongoing increases in the size of human genotype and phenotype collections offer the promise of improved understanding of the genetics of complex diseases. In addition to the biological insights that can be gained from the nature of the variants that contribute to the genetic component of co...

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Autores principales: Declan Bennett, Donal O’Shea, John Ferguson, Derek Morris, Cathal Seoighe
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2021
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Acceso en línea:https://doaj.org/article/10af198e88bd4aad98597e673ebec426
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