Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up

Introduction:Two-dimensional speckle tracking echocardiography (2D-STE) is sensitive in the assessment of left ventricular (LV) systolic function and may aid in diagnosis of late cardiac effects in asymptomatic Hodgkin’s lymphoma (HL) survivors in long-term follow-up.Methods:This is a cross-sectiona...

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Autores principales:	Mustafa Altınkaynak, Pelin Karaca Özer, Adem Atıcı, Rafet Başar, Nida Öztop, Berrin Umman, Meliha Nalçacı
Formato:	article
Lenguaje:	EN
Publicado:	Galenos Yayinevi 2021
Materias:	cardiomyopathy cardiotoxicity cardio-oncology diastolic dysfunction hodgkin’s disease strain echocardiography Medicine R
Acceso en línea:	https://doaj.org/article/10b417fb8791475dbd523f6f45a43338
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spelling	oai:doaj.org-article:10b417fb8791475dbd523f6f45a433382021-11-23T10:25:25ZAssessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up2619-97932148-094X10.4274/imj.galenos.2021.07448https://doaj.org/article/10b417fb8791475dbd523f6f45a433382021-11-01T00:00:00Z http://istanbulmedicaljournal.org/archives/archive-detail/article-preview/assessment-of-left-ventricular-function-using-a-tw/49714 https://doaj.org/toc/2619-9793https://doaj.org/toc/2148-094XIntroduction:Two-dimensional speckle tracking echocardiography (2D-STE) is sensitive in the assessment of left ventricular (LV) systolic function and may aid in diagnosis of late cardiac effects in asymptomatic Hodgkin’s lymphoma (HL) survivors in long-term follow-up.Methods:This is a cross-sectional study of 21 HL survivors previously treated with anthracyclines, with (8/21) or withoutmediastinal (8/21) radiotherapy and no recurrence at least 3 years after treatment compared to age-matched 43 healthy volunteers. To assess long-term cardiac complications, we performed 12-lead electrocardiography and 2D transthoracic echocardiography. In addition to conventional echocardiographic parameters, we used tissue Doppler echocardiography for LV diastolic functions and 2D-STE for evaluating the global longitudinal strain (GLS) of the LV myocardium.Results:The mean age of the HL survivors was 40±15 years and the female sex was predominant (11/21). The average PR interval of the HL survivors was significantly longer (154.7±19.6 ms vs 133.8±13.9 ms, p<0.001) while the QTc interval was significantly shorter (383.8±18.7 ms vs 402.4±11.7 ms, p<0.001) than the control group. HL survivors had significantly impaired GLS compared to the control group (-19.3±2.6 vs -22.6±1.6, p<0.001). Thirteen of the HL survivors (61%) with normal LV ejection fraction had impaired GLS. The frequency of left ventricular diastolic dysfunction (LVDD) in the HL survivors group was significantly higher than that of the control group (52% vs 26%, p=0.015). Therefore, LVDD was detected in 61.5% of patients with a GLS <-20%.Conclusion:2D-STE could be used in predicting late-onset subclinical cardiac side effects following treatment in asymptomatic HL survivors for long-term follow-up.Mustafa AltınkaynakPelin Karaca ÖzerAdem AtıcıRafet BaşarNida ÖztopBerrin UmmanMeliha NalçacıGalenos Yayineviarticlecardiomyopathycardiotoxicitycardio-oncologydiastolic dysfunctionhodgkin’s diseasestrain echocardiographyMedicineRENİstanbul Medical Journal, Vol 22, Iss 4, Pp 300-305 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	cardiomyopathy cardiotoxicity cardio-oncology diastolic dysfunction hodgkin’s disease strain echocardiography Medicine R
spellingShingle	cardiomyopathy cardiotoxicity cardio-oncology diastolic dysfunction hodgkin’s disease strain echocardiography Medicine R Mustafa Altınkaynak Pelin Karaca Özer Adem Atıcı Rafet Başar Nida Öztop Berrin Umman Meliha Nalçacı Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up
description	Introduction:Two-dimensional speckle tracking echocardiography (2D-STE) is sensitive in the assessment of left ventricular (LV) systolic function and may aid in diagnosis of late cardiac effects in asymptomatic Hodgkin’s lymphoma (HL) survivors in long-term follow-up.Methods:This is a cross-sectional study of 21 HL survivors previously treated with anthracyclines, with (8/21) or withoutmediastinal (8/21) radiotherapy and no recurrence at least 3 years after treatment compared to age-matched 43 healthy volunteers. To assess long-term cardiac complications, we performed 12-lead electrocardiography and 2D transthoracic echocardiography. In addition to conventional echocardiographic parameters, we used tissue Doppler echocardiography for LV diastolic functions and 2D-STE for evaluating the global longitudinal strain (GLS) of the LV myocardium.Results:The mean age of the HL survivors was 40±15 years and the female sex was predominant (11/21). The average PR interval of the HL survivors was significantly longer (154.7±19.6 ms vs 133.8±13.9 ms, p<0.001) while the QTc interval was significantly shorter (383.8±18.7 ms vs 402.4±11.7 ms, p<0.001) than the control group. HL survivors had significantly impaired GLS compared to the control group (-19.3±2.6 vs -22.6±1.6, p<0.001). Thirteen of the HL survivors (61%) with normal LV ejection fraction had impaired GLS. The frequency of left ventricular diastolic dysfunction (LVDD) in the HL survivors group was significantly higher than that of the control group (52% vs 26%, p=0.015). Therefore, LVDD was detected in 61.5% of patients with a GLS <-20%.Conclusion:2D-STE could be used in predicting late-onset subclinical cardiac side effects following treatment in asymptomatic HL survivors for long-term follow-up.
format	article
author	Mustafa Altınkaynak Pelin Karaca Özer Adem Atıcı Rafet Başar Nida Öztop Berrin Umman Meliha Nalçacı
author_facet	Mustafa Altınkaynak Pelin Karaca Özer Adem Atıcı Rafet Başar Nida Öztop Berrin Umman Meliha Nalçacı
author_sort	Mustafa Altınkaynak
title	Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up
title_short	Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up
title_full	Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up
title_fullStr	Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up
title_full_unstemmed	Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up
title_sort	assessment of left ventricular function using a two-dimensional speckle tracking echocardiography in asymptomatic survivors of hodgkin’s lymphoma in long-term follow-up
publisher	Galenos Yayinevi
publishDate	2021
url	https://doaj.org/article/10b417fb8791475dbd523f6f45a43338
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Assessment of Left Ventricular Function using a Two-Dimensional Speckle Tracking Echocardiography in Asymptomatic Survivors of Hodgkin’s Lymphoma in Long-Term Follow-Up

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