Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth

Abstract Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep pro...

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Autores principales:	Marion I. van den Heuvel, Jasmine L. Hect, Benjamin L. Smarr, Tamara Qawasmeh, Lance J. Kriegsfeld, Jeanne Barcelona, Kowsar E. Hijazi, Moriah E. Thomason
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10b4192441004b6492e2d7e1410206d7
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spelling	oai:doaj.org-article:10b4192441004b6492e2d7e1410206d72021-12-02T14:16:26ZMaternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth10.1038/s41598-021-81681-y2045-2322https://doaj.org/article/10b4192441004b6492e2d7e1410206d72021-01-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-81681-yhttps://doaj.org/toc/2045-2322Abstract Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in toddlers. We also examined whether fetal brain connectivity has direct or indirect influence on this putative association. Pregnant women underwent fetal resting-state functional connectivity MRI and completed questionnaires on stress, worry, and negative affect. At 3-year follow-up, 64 mothers reported on child sleep problems, and in the subset that have reached 5-year follow-up, actigraphy data (N = 25) has also been obtained. We observe that higher maternal prenatal stress is associated with increased toddler sleep concerns, with actigraphy sleep metrics, and with decreased fetal cerebellar-insular connectivity. Specific mediating effects were not identified for the fetal brain regions examined. The search for underlying mechanisms of the link between maternal prenatal stress and child sleep problems should be continued and extended to other brain areas.Marion I. van den HeuvelJasmine L. HectBenjamin L. SmarrTamara QawasmehLance J. KriegsfeldJeanne BarcelonaKowsar E. HijaziMoriah E. ThomasonNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Marion I. van den Heuvel Jasmine L. Hect Benjamin L. Smarr Tamara Qawasmeh Lance J. Kriegsfeld Jeanne Barcelona Kowsar E. Hijazi Moriah E. Thomason Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
description	Abstract Child sleep disorders are increasingly prevalent and understanding early predictors of sleep problems, starting in utero, may meaningfully guide future prevention efforts. Here, we investigated whether prenatal exposure to maternal psychological stress is associated with increased sleep problems in toddlers. We also examined whether fetal brain connectivity has direct or indirect influence on this putative association. Pregnant women underwent fetal resting-state functional connectivity MRI and completed questionnaires on stress, worry, and negative affect. At 3-year follow-up, 64 mothers reported on child sleep problems, and in the subset that have reached 5-year follow-up, actigraphy data (N = 25) has also been obtained. We observe that higher maternal prenatal stress is associated with increased toddler sleep concerns, with actigraphy sleep metrics, and with decreased fetal cerebellar-insular connectivity. Specific mediating effects were not identified for the fetal brain regions examined. The search for underlying mechanisms of the link between maternal prenatal stress and child sleep problems should be continued and extended to other brain areas.
format	article
author	Marion I. van den Heuvel Jasmine L. Hect Benjamin L. Smarr Tamara Qawasmeh Lance J. Kriegsfeld Jeanne Barcelona Kowsar E. Hijazi Moriah E. Thomason
author_facet	Marion I. van den Heuvel Jasmine L. Hect Benjamin L. Smarr Tamara Qawasmeh Lance J. Kriegsfeld Jeanne Barcelona Kowsar E. Hijazi Moriah E. Thomason
author_sort	Marion I. van den Heuvel
title	Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_short	Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_full	Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_fullStr	Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_full_unstemmed	Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
title_sort	maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10b4192441004b6492e2d7e1410206d7
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Maternal stress during pregnancy alters fetal cortico-cerebellar connectivity in utero and increases child sleep problems after birth

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