Persistence and reversal of plasmid-mediated antibiotic resistance

It is unclear whether the transfer of plasmids carrying antibiotic resistance genes can explain their persistence when antibiotics are not present. Here, Lopatkin et al. show that conjugal plasmids, even when costly, are indeed transferred at sufficiently high rates to be maintained in the absence o...

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Autores principales: Allison J. Lopatkin, Hannah R. Meredith, Jaydeep K. Srimani, Connor Pfeiffer, Rick Durrett, Lingchong You
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2017
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Acceso en línea:https://doaj.org/article/10bb373fb9b849cb90cc4010bf2d8a82
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Sumario:It is unclear whether the transfer of plasmids carrying antibiotic resistance genes can explain their persistence when antibiotics are not present. Here, Lopatkin et al. show that conjugal plasmids, even when costly, are indeed transferred at sufficiently high rates to be maintained in the absence of antibiotics.