Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes

Previous studies report that mutant p53 proteins have gain-of-function activities and cause oncogenic phenotypes. Herein, the authors engineered two isogenic epithelial cell lines to express wild-type or missense mutant p53 or be deficient for p53 protein and show that aneuploidy drives several of t...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Lindsay N. Redman-Rivera, Timothy M. Shaver, Hailing Jin, Clayton B. Marshall, Johanna M. Schafer, Quanhu Sheng, Rachel A. Hongo, Kathryn E. Beckermann, Ferrin C. Wheeler, Brian D. Lehmann, Jennifer A. Pietenpol
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10bdca26a8b945f9a336e6d86641208a
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:10bdca26a8b945f9a336e6d86641208a
record_format	dspace
spelling	oai:doaj.org-article:10bdca26a8b945f9a336e6d86641208a2021-12-02T19:04:19ZAcquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes10.1038/s41467-021-25359-z2041-1723https://doaj.org/article/10bdca26a8b945f9a336e6d86641208a2021-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-25359-zhttps://doaj.org/toc/2041-1723Previous studies report that mutant p53 proteins have gain-of-function activities and cause oncogenic phenotypes. Herein, the authors engineered two isogenic epithelial cell lines to express wild-type or missense mutant p53 or be deficient for p53 protein and show that aneuploidy drives several of the GOF phenotypes previously ascribed to mutant p53.Lindsay N. Redman-RiveraTimothy M. ShaverHailing JinClayton B. MarshallJohanna M. SchaferQuanhu ShengRachel A. HongoKathryn E. BeckermannFerrin C. WheelerBrian D. LehmannJennifer A. PietenpolNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lindsay N. Redman-Rivera Timothy M. Shaver Hailing Jin Clayton B. Marshall Johanna M. Schafer Quanhu Sheng Rachel A. Hongo Kathryn E. Beckermann Ferrin C. Wheeler Brian D. Lehmann Jennifer A. Pietenpol Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes
description	Previous studies report that mutant p53 proteins have gain-of-function activities and cause oncogenic phenotypes. Herein, the authors engineered two isogenic epithelial cell lines to express wild-type or missense mutant p53 or be deficient for p53 protein and show that aneuploidy drives several of the GOF phenotypes previously ascribed to mutant p53.
format	article
author	Lindsay N. Redman-Rivera Timothy M. Shaver Hailing Jin Clayton B. Marshall Johanna M. Schafer Quanhu Sheng Rachel A. Hongo Kathryn E. Beckermann Ferrin C. Wheeler Brian D. Lehmann Jennifer A. Pietenpol
author_facet	Lindsay N. Redman-Rivera Timothy M. Shaver Hailing Jin Clayton B. Marshall Johanna M. Schafer Quanhu Sheng Rachel A. Hongo Kathryn E. Beckermann Ferrin C. Wheeler Brian D. Lehmann Jennifer A. Pietenpol
author_sort	Lindsay N. Redman-Rivera
title	Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes
title_short	Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes
title_full	Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes
title_fullStr	Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes
title_full_unstemmed	Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes
title_sort	acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10bdca26a8b945f9a336e6d86641208a
work_keys_str_mv	AT lindsaynredmanrivera acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT timothymshaver acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT hailingjin acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT claytonbmarshall acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT johannamschafer acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT quanhusheng acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT rachelahongo acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT kathrynebeckermann acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT ferrincwheeler acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT briandlehmann acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes AT jenniferapietenpol acquisitionofaneuploidydrivesmutantp53associatedgainoffunctionphenotypes
_version_	1718377191039827968

Acquisition of aneuploidy drives mutant p53-associated gain-of-function phenotypes

Ejemplares similares