Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life

Tarika Sivakumar, Kris V Kowdley Liver Institute Northwest Seattle, Seattle, WA, USACorrespondence: Kris V KowdleyLiver Institute Northwest, 3216 NE 45th Pl, Suite 212, Seattle, WA, 98105, Tel +1 206-536-3030Fax +1 206-524-0749Email kkowdley@liverinstitutenw.orgAbstract: Primary biliary cholangitis...

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Autores principales:	Sivakumar T, Kowdley KV
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2021
Materias:	primary biliary cholangitis depression anxiety fatigue quality of life chronic liver disease Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/10bf4180c1464533ac6b4a3557528f02
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spelling	oai:doaj.org-article:10bf4180c1464533ac6b4a3557528f022021-12-02T19:02:38ZAnxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life1179-1535https://doaj.org/article/10bf4180c1464533ac6b4a3557528f022021-08-01T00:00:00Zhttps://www.dovepress.com/anxiety-and-depression-in-patients-with-primary-biliary-cholangitis-cu-peer-reviewed-fulltext-article-HMERhttps://doaj.org/toc/1179-1535Tarika Sivakumar, Kris V Kowdley Liver Institute Northwest Seattle, Seattle, WA, USACorrespondence: Kris V KowdleyLiver Institute Northwest, 3216 NE 45th Pl, Suite 212, Seattle, WA, 98105, Tel +1 206-536-3030Fax +1 206-524-0749Email kkowdley@liverinstitutenw.orgAbstract: Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic cholestatic immune-mediated liver disease characterized by injury to intrahepatic bile ducts that may ultimately progress to cirrhosis and liver failure and result in the need for liver transplant or death without treatment. Ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) are approved therapies for PBC and are associated with a reduced risk of progression of disease, although patients may continue to experience significant symptoms of pruritus and fatigue independent of liver disease. The two most commonly reported symptoms among patients with PBC are fatigue and pruritus which may be debilitating, and negatively impact physical, mental, emotional, and social wellbeing. Intense symptom burden has been associated with depressive symptoms, cognitive defects, poor sleep schedules, and social isolation. This literature review explores the presence of anxiety and depressive symptoms in chronic liver disease, the impact of symptom burden on patients’ wellbeing, and available pharmaceutical and natural therapies.Keywords: primary biliary cholangitis, depression, anxiety, fatigue, quality of life, chronic liver diseaseSivakumar TKowdley KVDove Medical Pressarticleprimary biliary cholangitisdepressionanxietyfatiguequality of lifechronic liver diseaseDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 13, Pp 83-92 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	primary biliary cholangitis depression anxiety fatigue quality of life chronic liver disease Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	primary biliary cholangitis depression anxiety fatigue quality of life chronic liver disease Diseases of the digestive system. Gastroenterology RC799-869 Sivakumar T Kowdley KV Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life
description	Tarika Sivakumar, Kris V Kowdley Liver Institute Northwest Seattle, Seattle, WA, USACorrespondence: Kris V KowdleyLiver Institute Northwest, 3216 NE 45th Pl, Suite 212, Seattle, WA, 98105, Tel +1 206-536-3030Fax +1 206-524-0749Email kkowdley@liverinstitutenw.orgAbstract: Primary biliary cholangitis (PBC), formerly known as primary biliary cirrhosis, is a chronic cholestatic immune-mediated liver disease characterized by injury to intrahepatic bile ducts that may ultimately progress to cirrhosis and liver failure and result in the need for liver transplant or death without treatment. Ursodeoxycholic acid (UDCA) and obeticholic acid (OCA) are approved therapies for PBC and are associated with a reduced risk of progression of disease, although patients may continue to experience significant symptoms of pruritus and fatigue independent of liver disease. The two most commonly reported symptoms among patients with PBC are fatigue and pruritus which may be debilitating, and negatively impact physical, mental, emotional, and social wellbeing. Intense symptom burden has been associated with depressive symptoms, cognitive defects, poor sleep schedules, and social isolation. This literature review explores the presence of anxiety and depressive symptoms in chronic liver disease, the impact of symptom burden on patients’ wellbeing, and available pharmaceutical and natural therapies.Keywords: primary biliary cholangitis, depression, anxiety, fatigue, quality of life, chronic liver disease
format	article
author	Sivakumar T Kowdley KV
author_facet	Sivakumar T Kowdley KV
author_sort	Sivakumar T
title	Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life
title_short	Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life
title_full	Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life
title_fullStr	Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life
title_full_unstemmed	Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life
title_sort	anxiety and depression in patients with primary biliary cholangitis: current insights and impact on quality of life
publisher	Dove Medical Press
publishDate	2021
url	https://doaj.org/article/10bf4180c1464533ac6b4a3557528f02
work_keys_str_mv	AT sivakumart anxietyanddepressioninpatientswithprimarybiliarycholangitiscurrentinsightsandimpactonqualityoflife AT kowdleykv anxietyanddepressioninpatientswithprimarybiliarycholangitiscurrentinsightsandimpactonqualityoflife
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Anxiety and Depression in Patients with Primary Biliary Cholangitis: Current Insights and Impact on Quality of Life

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