Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology

In vitro maturation (IVM) is a promising assisted reproductive technology (ART) for human infertility treatment. However, when cumulus oocyte complexes (COCs) are removed from their follicular environment when manipulated in vitro, it can lead to a decrease of intra-oocyte cyclic adenosine 3’, 5’-mo...

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Autores principales:	Christie L Sun, Sally L Catt, Kiri Beilby, Mulyoto Pangestu
Formato:	article
Lenguaje:	EN
Publicado:	Diponegoro University 2020
Materias:	oocyte maturation infertility cyclic nucleotide Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/10bfa1490f664cf3b9614a28084f33c5
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spelling	oai:doaj.org-article:10bfa1490f664cf3b9614a28084f33c52021-11-05T16:47:43ZCyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology2503-217810.14710/jbtr.v6i3.9691https://doaj.org/article/10bfa1490f664cf3b9614a28084f33c52020-12-01T00:00:00Zhttps://ejournal2.undip.ac.id/index.php/jbtr/article/view/9691https://doaj.org/toc/2503-2178In vitro maturation (IVM) is a promising assisted reproductive technology (ART) for human infertility treatment. However, when cumulus oocyte complexes (COCs) are removed from their follicular environment when manipulated in vitro, it can lead to a decrease of intra-oocyte cyclic adenosine 3’, 5’-monophosphare (cAMP) causing spontaneous nuclear maturation and an asynchrony with the oocytes’ cytoplasmic maturation, resulting in poor embryo developmental outcomes. Nuclear and cytoplasmic synchrony is important during oocyte maturation within antral follicles. It is maintained partially by the actions of c-type natriuretic peptide (CNP) binding with natriuretic peptide receptor 2 (NPR2), supporting high cAMP levels thus holding the oocyte in meiotic arrest. Addition of CNP to pre-IVM media has the capacity of maintaining cAMP levels and thus improve synchrony. Moreover, in women with advanced maternal age, successful IVM of aging oocytes faces significant challenges due to the morphological and cellular changes. Inhibiting initiation of nuclear maturation by cAMP modulator, CNP during pre-IVM period and thus improve oocyte developmental competence regardless of oocyte age.Christie L SunSally L CattKiri BeilbyMulyoto PangestuDiponegoro Universityarticleoocytematurationinfertilitycyclic nucleotideMedicine (General)R5-920ENJournal of Biomedicine and Translational Research, Vol 6, Iss 3, Pp 110-120 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	oocyte maturation infertility cyclic nucleotide Medicine (General) R5-920
spellingShingle	oocyte maturation infertility cyclic nucleotide Medicine (General) R5-920 Christie L Sun Sally L Catt Kiri Beilby Mulyoto Pangestu Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology
description	In vitro maturation (IVM) is a promising assisted reproductive technology (ART) for human infertility treatment. However, when cumulus oocyte complexes (COCs) are removed from their follicular environment when manipulated in vitro, it can lead to a decrease of intra-oocyte cyclic adenosine 3’, 5’-monophosphare (cAMP) causing spontaneous nuclear maturation and an asynchrony with the oocytes’ cytoplasmic maturation, resulting in poor embryo developmental outcomes. Nuclear and cytoplasmic synchrony is important during oocyte maturation within antral follicles. It is maintained partially by the actions of c-type natriuretic peptide (CNP) binding with natriuretic peptide receptor 2 (NPR2), supporting high cAMP levels thus holding the oocyte in meiotic arrest. Addition of CNP to pre-IVM media has the capacity of maintaining cAMP levels and thus improve synchrony. Moreover, in women with advanced maternal age, successful IVM of aging oocytes faces significant challenges due to the morphological and cellular changes. Inhibiting initiation of nuclear maturation by cAMP modulator, CNP during pre-IVM period and thus improve oocyte developmental competence regardless of oocyte age.
format	article
author	Christie L Sun Sally L Catt Kiri Beilby Mulyoto Pangestu
author_facet	Christie L Sun Sally L Catt Kiri Beilby Mulyoto Pangestu
author_sort	Christie L Sun
title	Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology
title_short	Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology
title_full	Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology
title_fullStr	Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology
title_full_unstemmed	Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology
title_sort	cyclic nucleotide in oocyte in vitro maturation in assisted reproductive technology
publisher	Diponegoro University
publishDate	2020
url	https://doaj.org/article/10bfa1490f664cf3b9614a28084f33c5
work_keys_str_mv	AT christielsun cyclicnucleotideinoocyteinvitromaturationinassistedreproductivetechnology AT sallylcatt cyclicnucleotideinoocyteinvitromaturationinassistedreproductivetechnology AT kiribeilby cyclicnucleotideinoocyteinvitromaturationinassistedreproductivetechnology AT mulyotopangestu cyclicnucleotideinoocyteinvitromaturationinassistedreproductivetechnology
_version_	1718444083050971136

Cyclic nucleotide in oocyte In vitro maturation in Assisted Reproductive Technology

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