Pathogenesis of Endometriosis: New Insights into Prospective Therapies

Endometriosis is a female reproductive disorder characterized by growth of uterine cells and tissue in distant sites. Around 2–10% of women experience this condition during reproductive age, 35–50% of whom encounter fertility issues or pain. To date, there are no established methods for its early di...

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Autores principales:	Radhika Kapoor, Christina Anna Stratopoulou, Marie-Madeleine Dolmans
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	endometriosis pathogenesis inflammation estrogen signaling apoptosis epithelial–mesenchymal transition Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/10c299029b4c40ab8cf388fdc48de384
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spelling	oai:doaj.org-article:10c299029b4c40ab8cf388fdc48de3842021-11-11T17:09:38ZPathogenesis of Endometriosis: New Insights into Prospective Therapies10.3390/ijms2221117001422-00671661-6596https://doaj.org/article/10c299029b4c40ab8cf388fdc48de3842021-10-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/21/11700https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Endometriosis is a female reproductive disorder characterized by growth of uterine cells and tissue in distant sites. Around 2–10% of women experience this condition during reproductive age, 35–50% of whom encounter fertility issues or pain. To date, there are no established methods for its early diagnosis and treatment, other than surgical procedures and scans. It is difficult to identify the disease at its onset, unless symptoms such as infertility and/or pain are present. Determining the mechanisms involved in its pathogenesis is vital, not only to pave the way for early identification, but also for disease management and development of less invasive but successful treatment strategies. Endometriosis is characterized by cell proliferation, propagation, evasion of immunosurveillance, and invasive metastasis. This review reports the underlying mechanisms that are individually or collectively responsible for disease establishment and evolution. Treatment of endometriosis mainly involves hormone therapies, which may be undesirable or have their own repercussions. It is therefore important to devise alternative strategies that are both effective and cause fewer side effects. Use of phytochemicals may be one of them. This review focuses on pharmacological inhibitors that can be therapeutically investigated in terms of their effects on signaling pathways and/or mechanisms involved in the pathogenesis of endometriosis.Radhika KapoorChristina Anna StratopoulouMarie-Madeleine DolmansMDPI AGarticleendometriosispathogenesisinflammationestrogen signalingapoptosisepithelial–mesenchymal transitionBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 11700, p 11700 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	endometriosis pathogenesis inflammation estrogen signaling apoptosis epithelial–mesenchymal transition Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	endometriosis pathogenesis inflammation estrogen signaling apoptosis epithelial–mesenchymal transition Biology (General) QH301-705.5 Chemistry QD1-999 Radhika Kapoor Christina Anna Stratopoulou Marie-Madeleine Dolmans Pathogenesis of Endometriosis: New Insights into Prospective Therapies
description	Endometriosis is a female reproductive disorder characterized by growth of uterine cells and tissue in distant sites. Around 2–10% of women experience this condition during reproductive age, 35–50% of whom encounter fertility issues or pain. To date, there are no established methods for its early diagnosis and treatment, other than surgical procedures and scans. It is difficult to identify the disease at its onset, unless symptoms such as infertility and/or pain are present. Determining the mechanisms involved in its pathogenesis is vital, not only to pave the way for early identification, but also for disease management and development of less invasive but successful treatment strategies. Endometriosis is characterized by cell proliferation, propagation, evasion of immunosurveillance, and invasive metastasis. This review reports the underlying mechanisms that are individually or collectively responsible for disease establishment and evolution. Treatment of endometriosis mainly involves hormone therapies, which may be undesirable or have their own repercussions. It is therefore important to devise alternative strategies that are both effective and cause fewer side effects. Use of phytochemicals may be one of them. This review focuses on pharmacological inhibitors that can be therapeutically investigated in terms of their effects on signaling pathways and/or mechanisms involved in the pathogenesis of endometriosis.
format	article
author	Radhika Kapoor Christina Anna Stratopoulou Marie-Madeleine Dolmans
author_facet	Radhika Kapoor Christina Anna Stratopoulou Marie-Madeleine Dolmans
author_sort	Radhika Kapoor
title	Pathogenesis of Endometriosis: New Insights into Prospective Therapies
title_short	Pathogenesis of Endometriosis: New Insights into Prospective Therapies
title_full	Pathogenesis of Endometriosis: New Insights into Prospective Therapies
title_fullStr	Pathogenesis of Endometriosis: New Insights into Prospective Therapies
title_full_unstemmed	Pathogenesis of Endometriosis: New Insights into Prospective Therapies
title_sort	pathogenesis of endometriosis: new insights into prospective therapies
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/10c299029b4c40ab8cf388fdc48de384
work_keys_str_mv	AT radhikakapoor pathogenesisofendometriosisnewinsightsintoprospectivetherapies AT christinaannastratopoulou pathogenesisofendometriosisnewinsightsintoprospectivetherapies AT mariemadeleinedolmans pathogenesisofendometriosisnewinsightsintoprospectivetherapies
_version_	1718432161775747072

Pathogenesis of Endometriosis: New Insights into Prospective Therapies

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