Length-dependent gene misexpression is associated with Alzheimer’s disease progression

Abstract Recent reports show transcription preference for long genes in neuronal tissues compared with non-neuronal tissues, and a gene-length dependent change in expression in the neurodevelopmental disease Rett syndrome (RTT). Whether the gene-length dependent changes in expression seen in RTT mig...

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Autores principales:	Shahar Barbash, Thomas P. Sakmar
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10c4fb4d6a564e4dbffd519a381146e5
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spelling	oai:doaj.org-article:10c4fb4d6a564e4dbffd519a381146e52021-12-02T12:32:15ZLength-dependent gene misexpression is associated with Alzheimer’s disease progression10.1038/s41598-017-00250-42045-2322https://doaj.org/article/10c4fb4d6a564e4dbffd519a381146e52017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00250-4https://doaj.org/toc/2045-2322Abstract Recent reports show transcription preference for long genes in neuronal tissues compared with non-neuronal tissues, and a gene-length dependent change in expression in the neurodevelopmental disease Rett syndrome (RTT). Whether the gene-length dependent changes in expression seen in RTT might also be seen in neurodegenerative diseases is not yet known. However, a reasonable hypothesis is that similar effects might be seen in neurodegenerative diseases as well as in RTT since a common general feature of both illnesses involves progressive dysfunction of synapses. Here, we demonstrate a clear length-dependent gene misexpression in the most prevalent neurodegenerative disease, Alzheimer’s disease. We show that the effect is associated with disease progression and can be attributed specifically to neurons. In particular, we observed gene length-dependent down regulation on the level of the whole tissue and gene length-dependent up regulation on the level of single cells. Our analysis shows that a gene-length effect on expression can be found in degenerative neurological illnesses, such as Alzheimer’s disease. Additional investigation to elucidate the precise mechanism underlying gene-length dependent changes in expression is warranted.Shahar BarbashThomas P. SakmarNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-5 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shahar Barbash Thomas P. Sakmar Length-dependent gene misexpression is associated with Alzheimer’s disease progression
description	Abstract Recent reports show transcription preference for long genes in neuronal tissues compared with non-neuronal tissues, and a gene-length dependent change in expression in the neurodevelopmental disease Rett syndrome (RTT). Whether the gene-length dependent changes in expression seen in RTT might also be seen in neurodegenerative diseases is not yet known. However, a reasonable hypothesis is that similar effects might be seen in neurodegenerative diseases as well as in RTT since a common general feature of both illnesses involves progressive dysfunction of synapses. Here, we demonstrate a clear length-dependent gene misexpression in the most prevalent neurodegenerative disease, Alzheimer’s disease. We show that the effect is associated with disease progression and can be attributed specifically to neurons. In particular, we observed gene length-dependent down regulation on the level of the whole tissue and gene length-dependent up regulation on the level of single cells. Our analysis shows that a gene-length effect on expression can be found in degenerative neurological illnesses, such as Alzheimer’s disease. Additional investigation to elucidate the precise mechanism underlying gene-length dependent changes in expression is warranted.
format	article
author	Shahar Barbash Thomas P. Sakmar
author_facet	Shahar Barbash Thomas P. Sakmar
author_sort	Shahar Barbash
title	Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_short	Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_full	Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_fullStr	Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_full_unstemmed	Length-dependent gene misexpression is associated with Alzheimer’s disease progression
title_sort	length-dependent gene misexpression is associated with alzheimer’s disease progression
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/10c4fb4d6a564e4dbffd519a381146e5
work_keys_str_mv	AT shaharbarbash lengthdependentgenemisexpressionisassociatedwithalzheimersdiseaseprogression AT thomaspsakmar lengthdependentgenemisexpressionisassociatedwithalzheimersdiseaseprogression
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Length-dependent gene misexpression is associated with Alzheimer’s disease progression

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