Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder

Pengfei Cao,1,2,* Jun Xing,1,* Yin Cao,3 Qi Cheng,1 Xiaojing Sun,1 Qi Kang,1 Libin Dai,1 Xianju Zhou,3 Zixiang Song1 1Psychological Centre for Adolescents and Children, The Affiliated 102nd Hospital of The Second Military Medical University of People’s Liberation Army of China, Shanghai,...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Cao P, Xing J, Cao Y, Cheng Q, Sun X, Kang Q, Dai L, Zhou X, Song Z
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2018
Materias:	Attention deficit hyperactivity disorder Repetitive transcranial magnetic stimulation Atomoxetine Executive function Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/10c588f9417f462baaaa84252706f5c0
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:10c588f9417f462baaaa84252706f5c0
record_format	dspace
spelling	oai:doaj.org-article:10c588f9417f462baaaa84252706f5c02021-12-02T03:19:30ZClinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder1178-2021https://doaj.org/article/10c588f9417f462baaaa84252706f5c02018-11-01T00:00:00Zhttps://www.dovepress.com/clinical-effects-of-repetitive-transcranial-magnetic-stimulation-combi-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Pengfei Cao,1,2,* Jun Xing,1,* Yin Cao,3 Qi Cheng,1 Xiaojing Sun,1 Qi Kang,1 Libin Dai,1 Xianju Zhou,3 Zixiang Song1 1Psychological Centre for Adolescents and Children, The Affiliated 102nd Hospital of The Second Military Medical University of People’s Liberation Army of China, Shanghai, China; 2Department of Political Affairs, College of Politics, National Defense University of People’s Liberation Army of China, Beijing, China; 3Laboratory of Neurological Diseases, Department of Neurology, The Affiliated Changzhou No 2 People’s Hospital of Nanjing Medical University, Changzhou, China *These authors contributed equally to this work Objective: To explore the effect of repetitive transcranial magnetic stimulation (rTMS) combined with atomoxetine (ATX) in the treatment of attention-deficit hyperactivity disorder (ADHD). Methods: Sixty-four patients with newly diagnosed ADHD were enrolled from January 2016 to October 2017 from Psychological Centre for Adolescents and Children at 102th Hospital of People’s Liberation Army of China. These patients were randomly assigned to three groups according to treatment method: the rTMS group, the ATX group, and the rTMS+ ATX group. Before treatment and 6 weeks after treatment, clinical symptoms and executive functions of ADHD patients were evaluated with the Swanson, Nolan, and Pelham, Version IV (SNAP-IV) Questionnaire, continuous performance test, three subtests (arithmetic, digit span, and coding) of Wechsler Intelligence Scale for Children, as well as Iowa Gambling Tasks (IGT). The effects of treatment were compared among three groups. Results: After 6 weeks of treatment, the scores of all factors in the SNAP-IV questionnaire were lower than those before treatment in the three groups; the scores of three subtests of Wechsler Intelligence Scale for Children, continuous performance test, and IGT were also significantly higher than those before treatment. The rTMS+ ATX group had a better improvement in attention deficits and hyperactivity impulse on the SNAP-IV questionnaire compared with the other groups, and also had a higher efficacy on cold and hot executive functions such as arithmetic, forward numbers, coding, and IGT. In addition, the ATX group performed better than the rTMS group in coding and IGT. Conclusion: rTMS, ATX, and the combination therapy are effective in improving core symptoms and executive function in patients with ADHD. The combined treatment has significant therapeutic advantages over the single treatment groups. Compared with rTMS, the drug therapy has a better improvement in coding and IGT. Keywords: attention-deficit hyperactivity disorder, repetitive transcranial magnetic stimulation, atomoxetine, executive functionCao PXing JCao YCheng QSun XKang QDai LZhou XSong ZDove Medical PressarticleAttention deficit hyperactivity disorderRepetitive transcranial magnetic stimulationAtomoxetineExecutive functionNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 14, Pp 3231-3240 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Attention deficit hyperactivity disorder Repetitive transcranial magnetic stimulation Atomoxetine Executive function Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	Attention deficit hyperactivity disorder Repetitive transcranial magnetic stimulation Atomoxetine Executive function Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Cao P Xing J Cao Y Cheng Q Sun X Kang Q Dai L Zhou X Song Z Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder
description	Pengfei Cao,1,2,* Jun Xing,1,* Yin Cao,3 Qi Cheng,1 Xiaojing Sun,1 Qi Kang,1 Libin Dai,1 Xianju Zhou,3 Zixiang Song1 1Psychological Centre for Adolescents and Children, The Affiliated 102nd Hospital of The Second Military Medical University of People’s Liberation Army of China, Shanghai, China; 2Department of Political Affairs, College of Politics, National Defense University of People’s Liberation Army of China, Beijing, China; 3Laboratory of Neurological Diseases, Department of Neurology, The Affiliated Changzhou No 2 People’s Hospital of Nanjing Medical University, Changzhou, China *These authors contributed equally to this work Objective: To explore the effect of repetitive transcranial magnetic stimulation (rTMS) combined with atomoxetine (ATX) in the treatment of attention-deficit hyperactivity disorder (ADHD). Methods: Sixty-four patients with newly diagnosed ADHD were enrolled from January 2016 to October 2017 from Psychological Centre for Adolescents and Children at 102th Hospital of People’s Liberation Army of China. These patients were randomly assigned to three groups according to treatment method: the rTMS group, the ATX group, and the rTMS+ ATX group. Before treatment and 6 weeks after treatment, clinical symptoms and executive functions of ADHD patients were evaluated with the Swanson, Nolan, and Pelham, Version IV (SNAP-IV) Questionnaire, continuous performance test, three subtests (arithmetic, digit span, and coding) of Wechsler Intelligence Scale for Children, as well as Iowa Gambling Tasks (IGT). The effects of treatment were compared among three groups. Results: After 6 weeks of treatment, the scores of all factors in the SNAP-IV questionnaire were lower than those before treatment in the three groups; the scores of three subtests of Wechsler Intelligence Scale for Children, continuous performance test, and IGT were also significantly higher than those before treatment. The rTMS+ ATX group had a better improvement in attention deficits and hyperactivity impulse on the SNAP-IV questionnaire compared with the other groups, and also had a higher efficacy on cold and hot executive functions such as arithmetic, forward numbers, coding, and IGT. In addition, the ATX group performed better than the rTMS group in coding and IGT. Conclusion: rTMS, ATX, and the combination therapy are effective in improving core symptoms and executive function in patients with ADHD. The combined treatment has significant therapeutic advantages over the single treatment groups. Compared with rTMS, the drug therapy has a better improvement in coding and IGT. Keywords: attention-deficit hyperactivity disorder, repetitive transcranial magnetic stimulation, atomoxetine, executive function
format	article
author	Cao P Xing J Cao Y Cheng Q Sun X Kang Q Dai L Zhou X Song Z
author_facet	Cao P Xing J Cao Y Cheng Q Sun X Kang Q Dai L Zhou X Song Z
author_sort	Cao P
title	Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder
title_short	Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder
title_full	Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder
title_fullStr	Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder
title_full_unstemmed	Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder
title_sort	clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder
publisher	Dove Medical Press
publishDate	2018
url	https://doaj.org/article/10c588f9417f462baaaa84252706f5c0
work_keys_str_mv	AT caop clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder AT xingj clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder AT caoy clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder AT chengq clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder AT sunx clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder AT kangq clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder AT dail clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder AT zhoux clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder AT songz clinicaleffectsofrepetitivetranscranialmagneticstimulationcombinedwithatomoxetineinthetreatmentofattentiondeficithyperactivitydisorder
_version_	1718401776324968448

Clinical effects of repetitive transcranial magnetic stimulation combined with atomoxetine in the treatment of attention-deficit hyperactivity disorder

Ejemplares similares