Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells

Crohn's disease activates the inflammatory reactions to induce intestinal disorders. Enteral nutrition (EN) could exert general immunomodulatory effects. Cecal ligation and perforation (CLP) surgery was utilized to establish Crohn's disease mice models. Survival analysis, hematoxylin-eosin...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Di Zhao, Bo Yang, Chen Ye, Shaoyi Zhang, Xiaoqiong Lv, Qiyi Chen
Formato:	article
Lenguaje:	EN
Publicado:	SAGE Publishing 2021
Materias:	Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/10c70fa7c5764dbcbb0eab950b1a82ab
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:10c70fa7c5764dbcbb0eab950b1a82ab
record_format	dspace
spelling	oai:doaj.org-article:10c70fa7c5764dbcbb0eab950b1a82ab2021-12-02T07:35:24ZEnteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells1753-42591753-426710.1177/17534259211057038https://doaj.org/article/10c70fa7c5764dbcbb0eab950b1a82ab2021-10-01T00:00:00Zhttps://doi.org/10.1177/17534259211057038https://doaj.org/toc/1753-4259https://doaj.org/toc/1753-4267Crohn's disease activates the inflammatory reactions to induce intestinal disorders. Enteral nutrition (EN) could exert general immunomodulatory effects. Cecal ligation and perforation (CLP) surgery was utilized to establish Crohn's disease mice models. Survival analysis, hematoxylin-eosin staining, flow cytometry, ELISA, Western blot and liquid chromatography-tandem MS were applied. Baicalein was added to inhibit lipoxygenases. The survival rate was restored and inflammatory injury, exudate neutrophils in peritoneal lavage and serum levels of IL-6 and TNF-α were ameliorated by EN treatment as compared with CLP treatment. EN also increased ILC-3 content, 5/15-LOX level and RvD1-RvD5 in peritoneal lavage. Baicalein reversed all the detected effects of EN except ILC-3 content. EN could activate special pro-resolving mediators (SPMs) through ILCs to mitigate injuries of Crohn's disease.Di ZhaoBo YangChen YeShaoyi ZhangXiaoqiong LvQiyi ChenSAGE PublishingarticleImmunologic diseases. AllergyRC581-607ENInnate Immunity, Vol 27 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Immunologic diseases. Allergy RC581-607
spellingShingle	Immunologic diseases. Allergy RC581-607 Di Zhao Bo Yang Chen Ye Shaoyi Zhang Xiaoqiong Lv Qiyi Chen Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
description	Crohn's disease activates the inflammatory reactions to induce intestinal disorders. Enteral nutrition (EN) could exert general immunomodulatory effects. Cecal ligation and perforation (CLP) surgery was utilized to establish Crohn's disease mice models. Survival analysis, hematoxylin-eosin staining, flow cytometry, ELISA, Western blot and liquid chromatography-tandem MS were applied. Baicalein was added to inhibit lipoxygenases. The survival rate was restored and inflammatory injury, exudate neutrophils in peritoneal lavage and serum levels of IL-6 and TNF-α were ameliorated by EN treatment as compared with CLP treatment. EN also increased ILC-3 content, 5/15-LOX level and RvD1-RvD5 in peritoneal lavage. Baicalein reversed all the detected effects of EN except ILC-3 content. EN could activate special pro-resolving mediators (SPMs) through ILCs to mitigate injuries of Crohn's disease.
format	article
author	Di Zhao Bo Yang Chen Ye Shaoyi Zhang Xiaoqiong Lv Qiyi Chen
author_facet	Di Zhao Bo Yang Chen Ye Shaoyi Zhang Xiaoqiong Lv Qiyi Chen
author_sort	Di Zhao
title	Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
title_short	Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
title_full	Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
title_fullStr	Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
title_full_unstemmed	Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
title_sort	enteral nutrition ameliorates the symptoms of crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells
publisher	SAGE Publishing
publishDate	2021
url	https://doaj.org/article/10c70fa7c5764dbcbb0eab950b1a82ab
work_keys_str_mv	AT dizhao enteralnutritionamelioratesthesymptomsofcrohnsdiseaseinmiceviaactivatingspecialproresolvingmediatorsthroughinnatelymphoidcells AT boyang enteralnutritionamelioratesthesymptomsofcrohnsdiseaseinmiceviaactivatingspecialproresolvingmediatorsthroughinnatelymphoidcells AT chenye enteralnutritionamelioratesthesymptomsofcrohnsdiseaseinmiceviaactivatingspecialproresolvingmediatorsthroughinnatelymphoidcells AT shaoyizhang enteralnutritionamelioratesthesymptomsofcrohnsdiseaseinmiceviaactivatingspecialproresolvingmediatorsthroughinnatelymphoidcells AT xiaoqionglv enteralnutritionamelioratesthesymptomsofcrohnsdiseaseinmiceviaactivatingspecialproresolvingmediatorsthroughinnatelymphoidcells AT qiyichen enteralnutritionamelioratesthesymptomsofcrohnsdiseaseinmiceviaactivatingspecialproresolvingmediatorsthroughinnatelymphoidcells
_version_	1718399321095798784

Enteral nutrition ameliorates the symptoms of Crohn's disease in mice via activating special pro-resolving mediators through innate lymphoid cells

Ejemplares similares