Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes

Abstract Hepatitis B virus (HBV) is classified into several genotypes, correlated with different geographic distributions, clinical outcomes and susceptible human populations. It is crucial to investigate the evolutionary significance behind the diversification of HBV genotypes, because it improves...

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Autores principales:	Shengdi Li, Zhen Wang, Yixue Li, Guohui Ding
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10cb987564c647f0bbe5cad10cdc9a6a
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spelling	oai:doaj.org-article:10cb987564c647f0bbe5cad10cdc9a6a2021-12-02T11:41:10ZAdaptive evolution of proteins in hepatitis B virus during divergence of genotypes10.1038/s41598-017-02012-82045-2322https://doaj.org/article/10cb987564c647f0bbe5cad10cdc9a6a2017-05-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-02012-8https://doaj.org/toc/2045-2322Abstract Hepatitis B virus (HBV) is classified into several genotypes, correlated with different geographic distributions, clinical outcomes and susceptible human populations. It is crucial to investigate the evolutionary significance behind the diversification of HBV genotypes, because it improves our understanding of their pathological differences and pathogen-host interactions. Here, we performed comprehensive analysis of HBV genome sequences collected from public database. With a stringent criteria, we generated a dataset of 2992 HBV genomes from eight major genotypes. In particular, we applied a specified classification of non-synonymous and synonymous variants in overlapping regions, to distinguish joint and independent gene evolutions. We confirmed the presence of selective constraints over non-synonymous variants in consideration of overlapping regions. We then performed the McDonald-Kreitman test and revealed adaptive evolutions of non-synonymous variants during genotypic differentiation. Remarkably, we identified strong positive selection that drove the differentiation of PreS1 domain, which is an essential regulator involved in viral transmission. Our study presents novel evidences for the adaptive evolution of HBV genotypes, which suggests that these viruses evolve directionally for maintenance or improvement of successful infections.Shengdi LiZhen WangYixue LiGuohui DingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Shengdi Li Zhen Wang Yixue Li Guohui Ding Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
description	Abstract Hepatitis B virus (HBV) is classified into several genotypes, correlated with different geographic distributions, clinical outcomes and susceptible human populations. It is crucial to investigate the evolutionary significance behind the diversification of HBV genotypes, because it improves our understanding of their pathological differences and pathogen-host interactions. Here, we performed comprehensive analysis of HBV genome sequences collected from public database. With a stringent criteria, we generated a dataset of 2992 HBV genomes from eight major genotypes. In particular, we applied a specified classification of non-synonymous and synonymous variants in overlapping regions, to distinguish joint and independent gene evolutions. We confirmed the presence of selective constraints over non-synonymous variants in consideration of overlapping regions. We then performed the McDonald-Kreitman test and revealed adaptive evolutions of non-synonymous variants during genotypic differentiation. Remarkably, we identified strong positive selection that drove the differentiation of PreS1 domain, which is an essential regulator involved in viral transmission. Our study presents novel evidences for the adaptive evolution of HBV genotypes, which suggests that these viruses evolve directionally for maintenance or improvement of successful infections.
format	article
author	Shengdi Li Zhen Wang Yixue Li Guohui Ding
author_facet	Shengdi Li Zhen Wang Yixue Li Guohui Ding
author_sort	Shengdi Li
title	Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
title_short	Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
title_full	Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
title_fullStr	Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
title_full_unstemmed	Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes
title_sort	adaptive evolution of proteins in hepatitis b virus during divergence of genotypes
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/10cb987564c647f0bbe5cad10cdc9a6a
work_keys_str_mv	AT shengdili adaptiveevolutionofproteinsinhepatitisbvirusduringdivergenceofgenotypes AT zhenwang adaptiveevolutionofproteinsinhepatitisbvirusduringdivergenceofgenotypes AT yixueli adaptiveevolutionofproteinsinhepatitisbvirusduringdivergenceofgenotypes AT guohuiding adaptiveevolutionofproteinsinhepatitisbvirusduringdivergenceofgenotypes
_version_	1718395444845871104

Adaptive evolution of proteins in hepatitis B virus during divergence of genotypes

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