Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment

Gastric cancer (GC) is one of the most prevalent malignancies with an unfavorable survival rate. Immunotherapy may contribute to a better prognosis. However, several phase III trials failed. Circular RNA (circRNA) is a novel type of non-coding RNA, plays a vital role in the progression of tumors. Th...

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Autores principales:	Xianghui Li, Zhiyan Li, Ping Liu, Shichao Ai, Feng Sun, Qiongyuan Hu, Yuxiang Dong, Xuefeng Xia, Wenxian Guan, Song Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gastric cancer Immunotherapy novel circular RNA ceRNA axis immunosuppressive microenvironment Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/10cff8d04ecc4b109debdd4720a92a38
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spelling	oai:doaj.org-article:10cff8d04ecc4b109debdd4720a92a382021-11-08T05:45:12ZNovel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment2296-858X10.3389/fmed.2021.771206https://doaj.org/article/10cff8d04ecc4b109debdd4720a92a382021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmed.2021.771206/fullhttps://doaj.org/toc/2296-858XGastric cancer (GC) is one of the most prevalent malignancies with an unfavorable survival rate. Immunotherapy may contribute to a better prognosis. However, several phase III trials failed. Circular RNA (circRNA) is a novel type of non-coding RNA, plays a vital role in the progression of tumors. The expression and function of circRNA in the GC immune microenvironment remain obscure. In this study, we utilized a bioinformatic analysis to construct a circRNA/microRNA (miRNA)/messenger RNA (mRNA) network involved in the progression and prognosis of GC. CircRNA DYRK1A_017, circRNA FLNA_118, miR-6512-3p, miR-6270-5p, and VCAN were identified as the key molecules in the hub regulatory axis. Dysregulation of this axis contributed to the cancer-associated signaling pathways (epithelial-mesenchymal transition [EMT], Nuclear factor kappa β-Tumor necrosis factor-α (NFκβ-TNFα) signaling, and angiogenesis) and aberrant immune microenvironment (infiltration by tumor associated macrophage, regulatory T cell, and mast cell). More importantly, the immunosuppressive tumor microenvironment may reveal the mechanism of novel circRNAs in tumors and serve as the target of immunotherapy.Xianghui LiZhiyan LiPing LiuShichao AiFeng SunQiongyuan HuYuxiang DongXuefeng XiaWenxian GuanSong LiuFrontiers Media S.A.articlegastric cancerImmunotherapynovel circular RNAceRNA axisimmunosuppressive microenvironmentMedicine (General)R5-920ENFrontiers in Medicine, Vol 8 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gastric cancer Immunotherapy novel circular RNA ceRNA axis immunosuppressive microenvironment Medicine (General) R5-920
spellingShingle	gastric cancer Immunotherapy novel circular RNA ceRNA axis immunosuppressive microenvironment Medicine (General) R5-920 Xianghui Li Zhiyan Li Ping Liu Shichao Ai Feng Sun Qiongyuan Hu Yuxiang Dong Xuefeng Xia Wenxian Guan Song Liu Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment
description	Gastric cancer (GC) is one of the most prevalent malignancies with an unfavorable survival rate. Immunotherapy may contribute to a better prognosis. However, several phase III trials failed. Circular RNA (circRNA) is a novel type of non-coding RNA, plays a vital role in the progression of tumors. The expression and function of circRNA in the GC immune microenvironment remain obscure. In this study, we utilized a bioinformatic analysis to construct a circRNA/microRNA (miRNA)/messenger RNA (mRNA) network involved in the progression and prognosis of GC. CircRNA DYRK1A_017, circRNA FLNA_118, miR-6512-3p, miR-6270-5p, and VCAN were identified as the key molecules in the hub regulatory axis. Dysregulation of this axis contributed to the cancer-associated signaling pathways (epithelial-mesenchymal transition [EMT], Nuclear factor kappa β-Tumor necrosis factor-α (NFκβ-TNFα) signaling, and angiogenesis) and aberrant immune microenvironment (infiltration by tumor associated macrophage, regulatory T cell, and mast cell). More importantly, the immunosuppressive tumor microenvironment may reveal the mechanism of novel circRNAs in tumors and serve as the target of immunotherapy.
format	article
author	Xianghui Li Zhiyan Li Ping Liu Shichao Ai Feng Sun Qiongyuan Hu Yuxiang Dong Xuefeng Xia Wenxian Guan Song Liu
author_facet	Xianghui Li Zhiyan Li Ping Liu Shichao Ai Feng Sun Qiongyuan Hu Yuxiang Dong Xuefeng Xia Wenxian Guan Song Liu
author_sort	Xianghui Li
title	Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment
title_short	Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment
title_full	Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment
title_fullStr	Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment
title_full_unstemmed	Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment
title_sort	novel circrnas in hub cerna axis regulate gastric cancer prognosis and microenvironment
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/10cff8d04ecc4b109debdd4720a92a38
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_version_	1718442879645384704

Novel CircRNAs in Hub ceRNA Axis Regulate Gastric Cancer Prognosis and Microenvironment

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