Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses

Abstract Following cervical and uterine cancer, ovarian cancer (OC) has the third rank in gynecologic cancers. It often remains non-diagnosed until it spreads throughout the pelvis and abdomen. Identification of the most effective risk factors can help take prevention measures concerning OC. Therefo...

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Autores principales:	Kiarash Tanha, Azadeh Mottaghi, Marzieh Nojomi, Marzieh Moradi, Rezvan Rajabzadeh, Samaneh Lotfi, Leila Janani
Formato:	article
Lenguaje:	EN
Publicado:	BMC 2021
Materias:	Ovarian cancer Risk factor Protective factor Nutritional factors Genetic factors Environmental factors Gynecology and obstetrics RG1-991
Acceso en línea:	https://doaj.org/article/10d1038036f442c9a7aa172c1127debd
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spelling	oai:doaj.org-article:10d1038036f442c9a7aa172c1127debd2021-11-14T12:31:57ZInvestigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses10.1186/s13048-021-00911-z1757-2215https://doaj.org/article/10d1038036f442c9a7aa172c1127debd2021-11-01T00:00:00Zhttps://doi.org/10.1186/s13048-021-00911-zhttps://doaj.org/toc/1757-2215Abstract Following cervical and uterine cancer, ovarian cancer (OC) has the third rank in gynecologic cancers. It often remains non-diagnosed until it spreads throughout the pelvis and abdomen. Identification of the most effective risk factors can help take prevention measures concerning OC. Therefore, the presented review aims to summarize the available studies on OC risk factors. A comprehensive systematic literature search was performed to identify all published systematic reviews and meta-analysis on associated factors with ovarian cancer. Web of Science, Cochrane Library databases, and Google Scholar were searched up to 17th January 2020. This study was performed according to Smith et al. methodology for conducting a systematic review of systematic reviews. Twenty-eight thousand sixty-two papers were initially retrieved from the electronic databases, among which 20,104 studies were screened. Two hundred seventy-seven articles met our inclusion criteria, 226 of which included in the meta-analysis. Most commonly reported genetic factors were MTHFR C677T (OR=1.077; 95 % CI (1.032, 1.124); P-value<0.001), BSML rs1544410 (OR=1.078; 95 %CI (1.024, 1.153); P-value=0.004), and Fokl rs2228570 (OR=1.123; 95 % CI (1.089, 1.157); P-value<0.001), which were significantly associated with increasing risk of ovarian cancer. Among the other factors, coffee intake (OR=1.106; 95 % CI (1.009, 1.211); P-value=0.030), hormone therapy (RR=1.057; 95 % CI (1.030, 1.400); P-value<0.001), hysterectomy (OR=0.863; 95 % CI (0.745, 0.999); P-value=0.049), and breast feeding (OR=0.719, 95 % CI (0.679, 0.762) and P-value<0.001) were mostly reported in studies. Among nutritional factors, coffee, egg, and fat intake significantly increase the risk of ovarian cancer. Estrogen, estrogen-progesterone, and overall hormone therapies also are related to the higher incidence of ovarian cancer. Some diseases, such as diabetes, endometriosis, and polycystic ovarian syndrome, as well as several genetic polymorphisms, cause a significant increase in ovarian cancer occurrence. Moreover, other factors, for instance, obesity, overweight, smoking, and perineal talc use, significantly increase the risk of ovarian cancer.Kiarash TanhaAzadeh MottaghiMarzieh NojomiMarzieh MoradiRezvan RajabzadehSamaneh LotfiLeila JananiBMCarticleOvarian cancerRisk factorProtective factorNutritional factorsGenetic factorsEnvironmental factorsGynecology and obstetricsRG1-991ENJournal of Ovarian Research, Vol 14, Iss 1, Pp 1-17 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Ovarian cancer Risk factor Protective factor Nutritional factors Genetic factors Environmental factors Gynecology and obstetrics RG1-991
spellingShingle	Ovarian cancer Risk factor Protective factor Nutritional factors Genetic factors Environmental factors Gynecology and obstetrics RG1-991 Kiarash Tanha Azadeh Mottaghi Marzieh Nojomi Marzieh Moradi Rezvan Rajabzadeh Samaneh Lotfi Leila Janani Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses
description	Abstract Following cervical and uterine cancer, ovarian cancer (OC) has the third rank in gynecologic cancers. It often remains non-diagnosed until it spreads throughout the pelvis and abdomen. Identification of the most effective risk factors can help take prevention measures concerning OC. Therefore, the presented review aims to summarize the available studies on OC risk factors. A comprehensive systematic literature search was performed to identify all published systematic reviews and meta-analysis on associated factors with ovarian cancer. Web of Science, Cochrane Library databases, and Google Scholar were searched up to 17th January 2020. This study was performed according to Smith et al. methodology for conducting a systematic review of systematic reviews. Twenty-eight thousand sixty-two papers were initially retrieved from the electronic databases, among which 20,104 studies were screened. Two hundred seventy-seven articles met our inclusion criteria, 226 of which included in the meta-analysis. Most commonly reported genetic factors were MTHFR C677T (OR=1.077; 95 % CI (1.032, 1.124); P-value<0.001), BSML rs1544410 (OR=1.078; 95 %CI (1.024, 1.153); P-value=0.004), and Fokl rs2228570 (OR=1.123; 95 % CI (1.089, 1.157); P-value<0.001), which were significantly associated with increasing risk of ovarian cancer. Among the other factors, coffee intake (OR=1.106; 95 % CI (1.009, 1.211); P-value=0.030), hormone therapy (RR=1.057; 95 % CI (1.030, 1.400); P-value<0.001), hysterectomy (OR=0.863; 95 % CI (0.745, 0.999); P-value=0.049), and breast feeding (OR=0.719, 95 % CI (0.679, 0.762) and P-value<0.001) were mostly reported in studies. Among nutritional factors, coffee, egg, and fat intake significantly increase the risk of ovarian cancer. Estrogen, estrogen-progesterone, and overall hormone therapies also are related to the higher incidence of ovarian cancer. Some diseases, such as diabetes, endometriosis, and polycystic ovarian syndrome, as well as several genetic polymorphisms, cause a significant increase in ovarian cancer occurrence. Moreover, other factors, for instance, obesity, overweight, smoking, and perineal talc use, significantly increase the risk of ovarian cancer.
format	article
author	Kiarash Tanha Azadeh Mottaghi Marzieh Nojomi Marzieh Moradi Rezvan Rajabzadeh Samaneh Lotfi Leila Janani
author_facet	Kiarash Tanha Azadeh Mottaghi Marzieh Nojomi Marzieh Moradi Rezvan Rajabzadeh Samaneh Lotfi Leila Janani
author_sort	Kiarash Tanha
title	Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses
title_short	Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses
title_full	Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses
title_fullStr	Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses
title_full_unstemmed	Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses
title_sort	investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses
publisher	BMC
publishDate	2021
url	https://doaj.org/article/10d1038036f442c9a7aa172c1127debd
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Investigation on factors associated with ovarian cancer: an umbrella review of systematic review and meta-analyses

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