Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study

Abstract Optimal noninvasive brain stimulation parameters for the treatment of negative symptoms of schizophrenia remain unclear. Here, we aimed to investigate the clinical and biological effects of intermittent theta burst transcranial magnetic stimulation (iTBS) in patients with treatment-resistan...

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Autores principales:	Rémy Bation, Charline Magnin, Emmanuel Poulet, Marine Mondino, Jérôme Brunelin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Psychiatry RC435-571
Acceso en línea:	https://doaj.org/article/10d25ef312584e709236bc1f7f9c28e6
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spelling	oai:doaj.org-article:10d25ef312584e709236bc1f7f9c28e62021-12-02T12:09:44ZIntermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study10.1038/s41537-021-00138-32334-265Xhttps://doaj.org/article/10d25ef312584e709236bc1f7f9c28e62021-02-01T00:00:00Zhttps://doi.org/10.1038/s41537-021-00138-3https://doaj.org/toc/2334-265XAbstract Optimal noninvasive brain stimulation parameters for the treatment of negative symptoms of schizophrenia remain unclear. Here, we aimed to investigate the clinical and biological effects of intermittent theta burst transcranial magnetic stimulation (iTBS) in patients with treatment-resistant negative symptoms of schizophrenia (NCT00875498). In a randomized sham-controlled 2-arm study, 22 patients with schizophrenia and treatment-resistant negative symptoms received 20 sessions of either active (n = 12) or sham (n = 10) iTBS. Sessions were delivered twice a day on 10 consecutive working days. Negative symptom severity was assessed 5 times using the Scale for the Assessment of Negative Symptoms (SANS): before iTBS, after iTBS, and 1, 3, and 6 months after iTBS. As a secondary objective, we explored the acute effects of iTBS on functional connectivity of the left dorsolateral prefrontal cortex (DLPFC) using seed-based resting-state functional connectivity MRI (rsFC fMRI) images acquired before and after iTBS. Active iTBS over the left DLPFC significantly decreased negative symptoms severity compared to sham iTBS (F (3,60) = 3.321, p = 0.026). Post hoc analyses revealed that the difference between groups was significant 6 months after the end of stimulation sessions. Neuroimaging revealed an increase in rsFC between the left DLPFC and a brain region encompassing the right lateral occipital cortex and right angular gyrus and a right midbrain region that may encompass dopamine neuron cell bodies. Thus, iTBS over the left DLPFC can alleviate negative symptoms of schizophrenia. The effect might be driven by significant modulation of dopamine transmission.Rémy BationCharline MagninEmmanuel PouletMarine MondinoJérôme BrunelinNature PortfolioarticlePsychiatryRC435-571ENnpj Schizophrenia, Vol 7, Iss 1, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Psychiatry RC435-571
spellingShingle	Psychiatry RC435-571 Rémy Bation Charline Magnin Emmanuel Poulet Marine Mondino Jérôme Brunelin Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study
description	Abstract Optimal noninvasive brain stimulation parameters for the treatment of negative symptoms of schizophrenia remain unclear. Here, we aimed to investigate the clinical and biological effects of intermittent theta burst transcranial magnetic stimulation (iTBS) in patients with treatment-resistant negative symptoms of schizophrenia (NCT00875498). In a randomized sham-controlled 2-arm study, 22 patients with schizophrenia and treatment-resistant negative symptoms received 20 sessions of either active (n = 12) or sham (n = 10) iTBS. Sessions were delivered twice a day on 10 consecutive working days. Negative symptom severity was assessed 5 times using the Scale for the Assessment of Negative Symptoms (SANS): before iTBS, after iTBS, and 1, 3, and 6 months after iTBS. As a secondary objective, we explored the acute effects of iTBS on functional connectivity of the left dorsolateral prefrontal cortex (DLPFC) using seed-based resting-state functional connectivity MRI (rsFC fMRI) images acquired before and after iTBS. Active iTBS over the left DLPFC significantly decreased negative symptoms severity compared to sham iTBS (F (3,60) = 3.321, p = 0.026). Post hoc analyses revealed that the difference between groups was significant 6 months after the end of stimulation sessions. Neuroimaging revealed an increase in rsFC between the left DLPFC and a brain region encompassing the right lateral occipital cortex and right angular gyrus and a right midbrain region that may encompass dopamine neuron cell bodies. Thus, iTBS over the left DLPFC can alleviate negative symptoms of schizophrenia. The effect might be driven by significant modulation of dopamine transmission.
format	article
author	Rémy Bation Charline Magnin Emmanuel Poulet Marine Mondino Jérôme Brunelin
author_facet	Rémy Bation Charline Magnin Emmanuel Poulet Marine Mondino Jérôme Brunelin
author_sort	Rémy Bation
title	Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study
title_short	Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study
title_full	Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study
title_fullStr	Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study
title_full_unstemmed	Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study
title_sort	intermittent theta burst stimulation for negative symptoms of schizophrenia—a double-blind, sham-controlled pilot study
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10d25ef312584e709236bc1f7f9c28e6
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Intermittent theta burst stimulation for negative symptoms of schizophrenia—A double-blind, sham-controlled pilot study

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