IgA subclasses have different effector functions associated with distinct glycosylation profiles

Immunoglobulin A (IgA) has two subclasses, IgA1 and IgA2, but differential effects on inflammation are unclear. Here the authors show that IgA2, when compared with IgA1, has stronger pro-inflammatory functions associated with changed glycosylation and higher disease scores in patients with rheumatoi...

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Autores principales:	Ulrike Steffen, Carolien A. Koeleman, Maria V. Sokolova, Holger Bang, Arnd Kleyer, Jürgen Rech, Harald Unterweger, Martin Schicht, Fabian Garreis, Jonas Hahn, Fabian T. Andes, Fabian Hartmann, Madelaine Hahn, Aparna Mahajan, Friedrich Paulsen, Markus Hoffmann, Günter Lochnit, Luis E. Muñoz, Manfred Wuhrer, David Falck, Martin Herrmann, Georg Schett
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10d5aea8f2dd4168b05d11de004c1d68
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spelling	oai:doaj.org-article:10d5aea8f2dd4168b05d11de004c1d682021-12-02T17:33:14ZIgA subclasses have different effector functions associated with distinct glycosylation profiles10.1038/s41467-019-13992-82041-1723https://doaj.org/article/10d5aea8f2dd4168b05d11de004c1d682020-01-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-13992-8https://doaj.org/toc/2041-1723Immunoglobulin A (IgA) has two subclasses, IgA1 and IgA2, but differential effects on inflammation are unclear. Here the authors show that IgA2, when compared with IgA1, has stronger pro-inflammatory functions associated with changed glycosylation and higher disease scores in patients with rheumatoid arthritis.Ulrike SteffenCarolien A. KoelemanMaria V. SokolovaHolger BangArnd KleyerJürgen RechHarald UnterwegerMartin SchichtFabian GarreisJonas HahnFabian T. AndesFabian HartmannMadelaine HahnAparna MahajanFriedrich PaulsenMarkus HoffmannGünter LochnitLuis E. MuñozManfred WuhrerDavid FalckMartin HerrmannGeorg SchettNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Ulrike Steffen Carolien A. Koeleman Maria V. Sokolova Holger Bang Arnd Kleyer Jürgen Rech Harald Unterweger Martin Schicht Fabian Garreis Jonas Hahn Fabian T. Andes Fabian Hartmann Madelaine Hahn Aparna Mahajan Friedrich Paulsen Markus Hoffmann Günter Lochnit Luis E. Muñoz Manfred Wuhrer David Falck Martin Herrmann Georg Schett IgA subclasses have different effector functions associated with distinct glycosylation profiles
description	Immunoglobulin A (IgA) has two subclasses, IgA1 and IgA2, but differential effects on inflammation are unclear. Here the authors show that IgA2, when compared with IgA1, has stronger pro-inflammatory functions associated with changed glycosylation and higher disease scores in patients with rheumatoid arthritis.
format	article
author	Ulrike Steffen Carolien A. Koeleman Maria V. Sokolova Holger Bang Arnd Kleyer Jürgen Rech Harald Unterweger Martin Schicht Fabian Garreis Jonas Hahn Fabian T. Andes Fabian Hartmann Madelaine Hahn Aparna Mahajan Friedrich Paulsen Markus Hoffmann Günter Lochnit Luis E. Muñoz Manfred Wuhrer David Falck Martin Herrmann Georg Schett
author_facet	Ulrike Steffen Carolien A. Koeleman Maria V. Sokolova Holger Bang Arnd Kleyer Jürgen Rech Harald Unterweger Martin Schicht Fabian Garreis Jonas Hahn Fabian T. Andes Fabian Hartmann Madelaine Hahn Aparna Mahajan Friedrich Paulsen Markus Hoffmann Günter Lochnit Luis E. Muñoz Manfred Wuhrer David Falck Martin Herrmann Georg Schett
author_sort	Ulrike Steffen
title	IgA subclasses have different effector functions associated with distinct glycosylation profiles
title_short	IgA subclasses have different effector functions associated with distinct glycosylation profiles
title_full	IgA subclasses have different effector functions associated with distinct glycosylation profiles
title_fullStr	IgA subclasses have different effector functions associated with distinct glycosylation profiles
title_full_unstemmed	IgA subclasses have different effector functions associated with distinct glycosylation profiles
title_sort	iga subclasses have different effector functions associated with distinct glycosylation profiles
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/10d5aea8f2dd4168b05d11de004c1d68
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IgA subclasses have different effector functions associated with distinct glycosylation profiles

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