Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it coul...

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Auteurs principaux:	Fernanda M Cerqueira, Francisco R M Laurindo, Alicia J Kowaltowski
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2011
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/10d992073ec84d959a6f5f3f207035c5
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spelling	oai:doaj.org-article:10d992073ec84d959a6f5f3f207035c52021-11-18T06:56:28ZMild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.1932-620310.1371/journal.pone.0018433https://doaj.org/article/10d992073ec84d959a6f5f3f207035c52011-03-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/21483800/?tool=EBIhttps://doaj.org/toc/1932-6203Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.Fernanda M CerqueiraFrancisco R M LaurindoAlicia J KowaltowskiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 6, Iss 3, p e18433 (2011)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Fernanda M Cerqueira Francisco R M Laurindo Alicia J Kowaltowski Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.
description	Enhanced mitochondrial biogenesis promoted by eNOS activation is believed to play a central role in the beneficial effects of calorie restriction (CR). Since treatment of mice with dinitrophenol (DNP) promotes health and lifespan benefits similar to those observed in CR, we hypothesized that it could also impact biogenesis. We found that DNP and CR increase citrate synthase activity, PGC-1α, cytochrome c oxidase and mitofusin-2 expression, as well as fasting plasma levels of NO• products. In addition, eNOS and Akt phosphorylation in skeletal muscle and visceral adipose tissue was activated in fasting CR and DNP animals. Overall, our results indicate that systemic mild uncoupling activates eNOS and Akt-dependent pathways leading to mitochondrial biogenesis.
format	article
author	Fernanda M Cerqueira Francisco R M Laurindo Alicia J Kowaltowski
author_facet	Fernanda M Cerqueira Francisco R M Laurindo Alicia J Kowaltowski
author_sort	Fernanda M Cerqueira
title	Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.
title_short	Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.
title_full	Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.
title_fullStr	Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.
title_full_unstemmed	Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.
title_sort	mild mitochondrial uncoupling and calorie restriction increase fasting enos, akt and mitochondrial biogenesis.
publisher	Public Library of Science (PLoS)
publishDate	2011
url	https://doaj.org/article/10d992073ec84d959a6f5f3f207035c5
work_keys_str_mv	AT fernandamcerqueira mildmitochondrialuncouplingandcalorierestrictionincreasefastingenosaktandmitochondrialbiogenesis AT franciscormlaurindo mildmitochondrialuncouplingandcalorierestrictionincreasefastingenosaktandmitochondrialbiogenesis AT aliciajkowaltowski mildmitochondrialuncouplingandcalorierestrictionincreasefastingenosaktandmitochondrialbiogenesis
_version_	1718424150041690112

Mild mitochondrial uncoupling and calorie restriction increase fasting eNOS, akt and mitochondrial biogenesis.

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