Ybx1 fine-tunes PRC2 activities to control embryonic brain development

Polycomb repressive complex 2 (PRC2) methylates H3K27 and suppresses RNA polymerase II transcription by promoting a closed chromatin. Here the authors identify the transcription factor Ybx1 as an interactor that regulates the binding of PRC2 to chromatin and H3K27 methylation to promote the genetic...

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Autores principales:	Myron K. Evans, Yurika Matsui, Beisi Xu, Catherine Willis, Jennifer Loome, Luis Milburn, Yiping Fan, Vishwajeeth Pagala, Jamy C. Peng
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10dafc53b3674edca179a8e881dc6d9f
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spelling	oai:doaj.org-article:10dafc53b3674edca179a8e881dc6d9f2021-12-02T16:27:46ZYbx1 fine-tunes PRC2 activities to control embryonic brain development10.1038/s41467-020-17878-y2041-1723https://doaj.org/article/10dafc53b3674edca179a8e881dc6d9f2020-08-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-17878-yhttps://doaj.org/toc/2041-1723Polycomb repressive complex 2 (PRC2) methylates H3K27 and suppresses RNA polymerase II transcription by promoting a closed chromatin. Here the authors identify the transcription factor Ybx1 as an interactor that regulates the binding of PRC2 to chromatin and H3K27 methylation to promote the genetic programs underlying neural lineages and neural progenitor self-renewal–differentiation choices.Myron K. EvansYurika MatsuiBeisi XuCatherine WillisJennifer LoomeLuis MilburnYiping FanVishwajeeth PagalaJamy C. PengNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Myron K. Evans Yurika Matsui Beisi Xu Catherine Willis Jennifer Loome Luis Milburn Yiping Fan Vishwajeeth Pagala Jamy C. Peng Ybx1 fine-tunes PRC2 activities to control embryonic brain development
description	Polycomb repressive complex 2 (PRC2) methylates H3K27 and suppresses RNA polymerase II transcription by promoting a closed chromatin. Here the authors identify the transcription factor Ybx1 as an interactor that regulates the binding of PRC2 to chromatin and H3K27 methylation to promote the genetic programs underlying neural lineages and neural progenitor self-renewal–differentiation choices.
format	article
author	Myron K. Evans Yurika Matsui Beisi Xu Catherine Willis Jennifer Loome Luis Milburn Yiping Fan Vishwajeeth Pagala Jamy C. Peng
author_facet	Myron K. Evans Yurika Matsui Beisi Xu Catherine Willis Jennifer Loome Luis Milburn Yiping Fan Vishwajeeth Pagala Jamy C. Peng
author_sort	Myron K. Evans
title	Ybx1 fine-tunes PRC2 activities to control embryonic brain development
title_short	Ybx1 fine-tunes PRC2 activities to control embryonic brain development
title_full	Ybx1 fine-tunes PRC2 activities to control embryonic brain development
title_fullStr	Ybx1 fine-tunes PRC2 activities to control embryonic brain development
title_full_unstemmed	Ybx1 fine-tunes PRC2 activities to control embryonic brain development
title_sort	ybx1 fine-tunes prc2 activities to control embryonic brain development
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/10dafc53b3674edca179a8e881dc6d9f
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Ybx1 fine-tunes PRC2 activities to control embryonic brain development

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