Ybx1 fine-tunes PRC2 activities to control embryonic brain development
Polycomb repressive complex 2 (PRC2) methylates H3K27 and suppresses RNA polymerase II transcription by promoting a closed chromatin. Here the authors identify the transcription factor Ybx1 as an interactor that regulates the binding of PRC2 to chromatin and H3K27 methylation to promote the genetic...
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Autores principales: | Myron K. Evans, Yurika Matsui, Beisi Xu, Catherine Willis, Jennifer Loome, Luis Milburn, Yiping Fan, Vishwajeeth Pagala, Jamy C. Peng |
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Formato: | article |
Lenguaje: | EN |
Publicado: |
Nature Portfolio
2020
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Materias: | |
Acceso en línea: | https://doaj.org/article/10dafc53b3674edca179a8e881dc6d9f |
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