Ybx1 fine-tunes PRC2 activities to control embryonic brain development

Polycomb repressive complex 2 (PRC2) methylates H3K27 and suppresses RNA polymerase II transcription by promoting a closed chromatin. Here the authors identify the transcription factor Ybx1 as an interactor that regulates the binding of PRC2 to chromatin and H3K27 methylation to promote the genetic...

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Bibliographic Details
Main Authors: Myron K. Evans, Yurika Matsui, Beisi Xu, Catherine Willis, Jennifer Loome, Luis Milburn, Yiping Fan, Vishwajeeth Pagala, Jamy C. Peng
Format: article
Language:EN
Published: Nature Portfolio 2020
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Online Access:https://doaj.org/article/10dafc53b3674edca179a8e881dc6d9f
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