Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces

We know that air-water interfaces can generically inactivate viruses, but the mechanisms behind this observation are unclear. Here the authors use simulations to uncover those mechanisms and find that the electrostatic repulsive free energy of an RNA virus increases by several thousands of kBT as it...

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Autores principales:	C. A. Brackley, A. Lips, A. Morozov, W. C. K. Poon, D. Marenduzzo
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10dbd7880438414ba473842e24f2d028
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spelling	oai:doaj.org-article:10dbd7880438414ba473842e24f2d0282021-11-28T12:31:15ZMechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces10.1038/s41467-021-27052-72041-1723https://doaj.org/article/10dbd7880438414ba473842e24f2d0282021-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-27052-7https://doaj.org/toc/2041-1723We know that air-water interfaces can generically inactivate viruses, but the mechanisms behind this observation are unclear. Here the authors use simulations to uncover those mechanisms and find that the electrostatic repulsive free energy of an RNA virus increases by several thousands of kBT as it approaches an air-water interface, providing a mechanism for viral destabilization which may induce inactivation.C. A. BrackleyA. LipsA. MorozovW. C. K. PoonD. MarenduzzoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q C. A. Brackley A. Lips A. Morozov W. C. K. Poon D. Marenduzzo Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces
description	We know that air-water interfaces can generically inactivate viruses, but the mechanisms behind this observation are unclear. Here the authors use simulations to uncover those mechanisms and find that the electrostatic repulsive free energy of an RNA virus increases by several thousands of kBT as it approaches an air-water interface, providing a mechanism for viral destabilization which may induce inactivation.
format	article
author	C. A. Brackley A. Lips A. Morozov W. C. K. Poon D. Marenduzzo
author_facet	C. A. Brackley A. Lips A. Morozov W. C. K. Poon D. Marenduzzo
author_sort	C. A. Brackley
title	Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces
title_short	Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces
title_full	Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces
title_fullStr	Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces
title_full_unstemmed	Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces
title_sort	mechanisms for destabilisation of rna viruses at air-water and liquid-liquid interfaces
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/10dbd7880438414ba473842e24f2d028
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Mechanisms for destabilisation of RNA viruses at air-water and liquid-liquid interfaces

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