Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146.

<h4>Aims/hypothesis</h4>Polymorphisms in the transcription factor 7-like 2 (TCF7L2) gene have been shown to display a powerful association with type 2 diabetes. The aim of the present study was to evaluate metabolic alterations in carriers of a common TCF7L2 risk variant.<h4>Method...

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Auteurs principaux:	Cornelia Then, Simone Wahl, Anna Kirchhofer, Harald Grallert, Susanne Krug, Gabi Kastenmüller, Werner Römisch-Margl, Melina Claussnitzer, Thomas Illig, Margit Heier, Christa Meisinger, Jerzy Adamski, Barbara Thorand, Cornelia Huth, Annette Peters, Cornelia Prehn, Ina Heukamp, Helmut Laumen, Andreas Lechner, Hans Hauner, Jochen Seissler
Format:	article
Langue:	EN
Publié:	Public Library of Science (PLoS) 2013
Sujets:	Medicine R Science Q
Accès en ligne:	https://doaj.org/article/10dcb9f87dc441918c7b7b91ac273b05
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Plasma metabolomics reveal alterations of sphingo- and glycerophospholipid levels in non-diabetic carriers of the transcription factor 7-like 2 polymorphism rs7903146.

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