Persistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study

Introduction: The persistence positivity detected for severe acute respiratory syndrome coronavirus 2 ribonucleic acid by real-time reverse transcriptase-polymerase chain reaction test in asymptomatic coronavirus disease 2019 positive patients has attracted a lot of attention. There is limited data...

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Autores principales:	Narayani Maharjan, Niresh Thapa, Bibek Pun Magar, Muna Maharjan, Jiancheng Tu
Formato:	article
Lenguaje:	EN
Publicado:	Nepal Medical Association 2021
Materias:	COVID-19; recurrence; reverse transcriptase-polymerase chain reaction; SARS-CoV-2; viral shedding. Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/10de7192e72749d1a0b3ce8155ff8bc7
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spelling	oai:doaj.org-article:10de7192e72749d1a0b3ce8155ff8bc72021-11-18T19:19:52ZPersistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study10.31729/jnma.70770028-27151815-672Xhttps://doaj.org/article/10de7192e72749d1a0b3ce8155ff8bc72021-11-01T00:00:00Zhttp://www.jnma.com.np/jnma/index.php/jnma/article/view/7077https://doaj.org/toc/0028-2715https://doaj.org/toc/1815-672X Introduction: The persistence positivity detected for severe acute respiratory syndrome coronavirus 2 ribonucleic acid by real-time reverse transcriptase-polymerase chain reaction test in asymptomatic coronavirus disease 2019 positive patients has attracted a lot of attention. There is limited data on the duration of viral shedding. We aimed to determine the proportion of coronavirus disease patients with persistent positivity of real-time reverse transcriptase-polymerase chain reaction test in a teaching hospital of Nepal. Methods: A descriptive cross-sectional study was conducted using medical records from May to September 2020 in a teaching hospital of Nepal. The study was approved by the Institutional Review Committee of Karnali Academy of Health Sciences (Reference no 077/078/03). Convenient sampling method was used. Data was analysed by Statistical Package for the Social Sciences. Point estimate at 90% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Of the total 95 cases, 9 (9.5%) cases (4.6-14.4 at 90% Confidence Interval), were repeat positive after achieving the first negative. The mean day required of achieving the last negative for the repeat positive group was 62.11±3.95, range (60-70 days). The mean time duration for the virus shedding was found to be 20.43±12.19 days (range 7-60 days) after the first positive test result. Conclusions: This study concludes that there might be a persistent positivity of the polymerase chain reaction test among patients with COVID-19. The majority of the patients were test positive for 8-14 days, and some were positive till 60-70 days. Narayani MaharjanNiresh ThapaBibek Pun MagarMuna MaharjanJiancheng TuNepal Medical AssociationarticleCOVID-19; recurrence; reverse transcriptase-polymerase chain reaction; SARS-CoV-2; viral shedding.Medicine (General)R5-920ENJournal of Nepal Medical Association, Vol 59, Iss 243 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	COVID-19; recurrence; reverse transcriptase-polymerase chain reaction; SARS-CoV-2; viral shedding. Medicine (General) R5-920
spellingShingle	COVID-19; recurrence; reverse transcriptase-polymerase chain reaction; SARS-CoV-2; viral shedding. Medicine (General) R5-920 Narayani Maharjan Niresh Thapa Bibek Pun Magar Muna Maharjan Jiancheng Tu Persistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study
description	Introduction: The persistence positivity detected for severe acute respiratory syndrome coronavirus 2 ribonucleic acid by real-time reverse transcriptase-polymerase chain reaction test in asymptomatic coronavirus disease 2019 positive patients has attracted a lot of attention. There is limited data on the duration of viral shedding. We aimed to determine the proportion of coronavirus disease patients with persistent positivity of real-time reverse transcriptase-polymerase chain reaction test in a teaching hospital of Nepal. Methods: A descriptive cross-sectional study was conducted using medical records from May to September 2020 in a teaching hospital of Nepal. The study was approved by the Institutional Review Committee of Karnali Academy of Health Sciences (Reference no 077/078/03). Convenient sampling method was used. Data was analysed by Statistical Package for the Social Sciences. Point estimate at 90% Confidence Interval was calculated along with frequency and proportion for binary data. Results: Of the total 95 cases, 9 (9.5%) cases (4.6-14.4 at 90% Confidence Interval), were repeat positive after achieving the first negative. The mean day required of achieving the last negative for the repeat positive group was 62.11±3.95, range (60-70 days). The mean time duration for the virus shedding was found to be 20.43±12.19 days (range 7-60 days) after the first positive test result. Conclusions: This study concludes that there might be a persistent positivity of the polymerase chain reaction test among patients with COVID-19. The majority of the patients were test positive for 8-14 days, and some were positive till 60-70 days.
format	article
author	Narayani Maharjan Niresh Thapa Bibek Pun Magar Muna Maharjan Jiancheng Tu
author_facet	Narayani Maharjan Niresh Thapa Bibek Pun Magar Muna Maharjan Jiancheng Tu
author_sort	Narayani Maharjan
title	Persistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study
title_short	Persistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study
title_full	Persistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study
title_fullStr	Persistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study
title_full_unstemmed	Persistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study
title_sort	persistent positivity of reverse transcriptase-polymerase chain reaction test among patients with covid-19 in rural teaching hospital: a descriptive cross-sectional study
publisher	Nepal Medical Association
publishDate	2021
url	https://doaj.org/article/10de7192e72749d1a0b3ce8155ff8bc7
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Persistent Positivity of Reverse Transcriptase-Polymerase Chain Reaction Test among Patients with COVID-19 in Rural Teaching Hospital: A Descriptive Cross-sectional Study

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