Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression

Metabolic rewiring of cancer cells can be driven by both extrinsic and intrinsic factors. Here the authors show that microenvironmental factors induce metabolic rewiring of B-cell lymphoma through activation of STAT3 and NF-ΚB resulting in upregulation of the aminotransferase GOT2 and glutamine addi...

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Autores principales:	Maren Feist, Philipp Schwarzfischer, Paul Heinrich, Xueni Sun, Judith Kemper, Frederike von Bonin, Paula Perez-Rubio, Franziska Taruttis, Thorsten Rehberg, Katja Dettmer, Wolfram Gronwald, Jörg Reinders, Julia C. Engelmann, Jan Dudek, Wolfram Klapper, Lorenz Trümper, Rainer Spang, Peter J. Oefner, Dieter Kube
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2018
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/10dedebdb6144adc9af992f5ae10844d
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spelling	oai:doaj.org-article:10dedebdb6144adc9af992f5ae10844d2021-12-02T15:34:18ZCooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression10.1038/s41467-018-03803-x2041-1723https://doaj.org/article/10dedebdb6144adc9af992f5ae10844d2018-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-018-03803-xhttps://doaj.org/toc/2041-1723Metabolic rewiring of cancer cells can be driven by both extrinsic and intrinsic factors. Here the authors show that microenvironmental factors induce metabolic rewiring of B-cell lymphoma through activation of STAT3 and NF-ΚB resulting in upregulation of the aminotransferase GOT2 and glutamine addiction.Maren FeistPhilipp SchwarzfischerPaul HeinrichXueni SunJudith KemperFrederike von BoninPaula Perez-RubioFranziska TaruttisThorsten RehbergKatja DettmerWolfram GronwaldJörg ReindersJulia C. EngelmannJan DudekWolfram KlapperLorenz TrümperRainer SpangPeter J. OefnerDieter KubeNature PortfolioarticleScienceQENNature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Maren Feist Philipp Schwarzfischer Paul Heinrich Xueni Sun Judith Kemper Frederike von Bonin Paula Perez-Rubio Franziska Taruttis Thorsten Rehberg Katja Dettmer Wolfram Gronwald Jörg Reinders Julia C. Engelmann Jan Dudek Wolfram Klapper Lorenz Trümper Rainer Spang Peter J. Oefner Dieter Kube Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
description	Metabolic rewiring of cancer cells can be driven by both extrinsic and intrinsic factors. Here the authors show that microenvironmental factors induce metabolic rewiring of B-cell lymphoma through activation of STAT3 and NF-ΚB resulting in upregulation of the aminotransferase GOT2 and glutamine addiction.
format	article
author	Maren Feist Philipp Schwarzfischer Paul Heinrich Xueni Sun Judith Kemper Frederike von Bonin Paula Perez-Rubio Franziska Taruttis Thorsten Rehberg Katja Dettmer Wolfram Gronwald Jörg Reinders Julia C. Engelmann Jan Dudek Wolfram Klapper Lorenz Trümper Rainer Spang Peter J. Oefner Dieter Kube
author_facet	Maren Feist Philipp Schwarzfischer Paul Heinrich Xueni Sun Judith Kemper Frederike von Bonin Paula Perez-Rubio Franziska Taruttis Thorsten Rehberg Katja Dettmer Wolfram Gronwald Jörg Reinders Julia C. Engelmann Jan Dudek Wolfram Klapper Lorenz Trümper Rainer Spang Peter J. Oefner Dieter Kube
author_sort	Maren Feist
title	Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
title_short	Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
title_full	Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
title_fullStr	Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
title_full_unstemmed	Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression
title_sort	cooperative stat/nf-κb signaling regulates lymphoma metabolic reprogramming and aberrant got2 expression
publisher	Nature Portfolio
publishDate	2018
url	https://doaj.org/article/10dedebdb6144adc9af992f5ae10844d
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Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression

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