Parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.

Preeclampsia is a major cause of perinatal mortality and disease affecting 5-10% of all pregnancies worldwide, but its etiology remains poorly understood despite considerable research effort. Parent-offspring conflict theory suggests that such hypertensive disorders of pregnancy may have evolved thr...

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Autores principales:	Birgitte Hollegaard, Sean G Byars, Jacob Lykke, Jacobus J Boomsma
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2013
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10df0e8f11d74132a8e999bcb0302662
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spelling	oai:doaj.org-article:10df0e8f11d74132a8e999bcb03026622021-11-18T07:56:13ZParent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.1932-620310.1371/journal.pone.0056821https://doaj.org/article/10df0e8f11d74132a8e999bcb03026622013-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23451092/?tool=EBIhttps://doaj.org/toc/1932-6203Preeclampsia is a major cause of perinatal mortality and disease affecting 5-10% of all pregnancies worldwide, but its etiology remains poorly understood despite considerable research effort. Parent-offspring conflict theory suggests that such hypertensive disorders of pregnancy may have evolved through the ability of fetal genes to increase maternal blood pressure as this enhances general nutrient supply. However, such mechanisms for inducing hypertension in pregnancy would need to incur sufficient offspring health benefits to compensate for the obvious risks for maternal and fetal health towards the end of pregnancy in order to explain why these disorders have not been removed by natural selection in our hunter-gatherer ancestors. We analyzed >750,000 live births in the Danish National Patient Registry and all registered medical diagnoses for up to 30 years after birth. We show that offspring exposed to pregnancy-induced hypertension (PIH) in trimester 1 had significantly reduced overall later-life disease risks, but increased risks when PIH exposure started or developed as preeclampsia in later trimesters. Similar patterns were found for first-year mortality. These results suggest that early PIH leading to improved postpartum survival and health represents a balanced compromise between the reproductive interests of parents and offspring, whereas later onset of PIH may reflect an unbalanced parent-offspring conflict at the detriment of maternal and offspring health.Birgitte HollegaardSean G ByarsJacob LykkeJacobus J BoomsmaPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 8, Iss 2, p e56821 (2013)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Birgitte Hollegaard Sean G Byars Jacob Lykke Jacobus J Boomsma Parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.
description	Preeclampsia is a major cause of perinatal mortality and disease affecting 5-10% of all pregnancies worldwide, but its etiology remains poorly understood despite considerable research effort. Parent-offspring conflict theory suggests that such hypertensive disorders of pregnancy may have evolved through the ability of fetal genes to increase maternal blood pressure as this enhances general nutrient supply. However, such mechanisms for inducing hypertension in pregnancy would need to incur sufficient offspring health benefits to compensate for the obvious risks for maternal and fetal health towards the end of pregnancy in order to explain why these disorders have not been removed by natural selection in our hunter-gatherer ancestors. We analyzed >750,000 live births in the Danish National Patient Registry and all registered medical diagnoses for up to 30 years after birth. We show that offspring exposed to pregnancy-induced hypertension (PIH) in trimester 1 had significantly reduced overall later-life disease risks, but increased risks when PIH exposure started or developed as preeclampsia in later trimesters. Similar patterns were found for first-year mortality. These results suggest that early PIH leading to improved postpartum survival and health represents a balanced compromise between the reproductive interests of parents and offspring, whereas later onset of PIH may reflect an unbalanced parent-offspring conflict at the detriment of maternal and offspring health.
format	article
author	Birgitte Hollegaard Sean G Byars Jacob Lykke Jacobus J Boomsma
author_facet	Birgitte Hollegaard Sean G Byars Jacob Lykke Jacobus J Boomsma
author_sort	Birgitte Hollegaard
title	Parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.
title_short	Parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.
title_full	Parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.
title_fullStr	Parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.
title_full_unstemmed	Parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.
title_sort	parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.
publisher	Public Library of Science (PLoS)
publishDate	2013
url	https://doaj.org/article/10df0e8f11d74132a8e999bcb0302662
work_keys_str_mv	AT birgittehollegaard parentoffspringconflictandthepersistenceofpregnancyinducedhypertensioninmodernhumans AT seangbyars parentoffspringconflictandthepersistenceofpregnancyinducedhypertensioninmodernhumans AT jacoblykke parentoffspringconflictandthepersistenceofpregnancyinducedhypertensioninmodernhumans AT jacobusjboomsma parentoffspringconflictandthepersistenceofpregnancyinducedhypertensioninmodernhumans
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Parent-offspring conflict and the persistence of pregnancy-induced hypertension in modern humans.

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