Clinical and immunological aspects of microRNAs in neonatal sepsis

Neonatal sepsis constitutes a highly relevant public health challenge and is the most common cause of infant morbidity and mortality worldwide. Recent studies have demonstrated that during infection epigenetic changes may occur leading to reprogramming of gene expression. Post-transcriptional regula...

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Autores principales:	Ahlam Fatmi, Nafissa Chabni, María Cernada, Máximo Vento, María González-López, Mourad Aribi, Federico V. Pallardó, José Luis García-Giménez
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2022
Materias:	MicroRNAs Epigenetic changes Immunity Inflammation Neonatal sepsis Therapeutics. Pharmacology RM1-950
Acceso en línea:	https://doaj.org/article/10df9b38dcd44cac8d816645a858237a
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spelling	oai:doaj.org-article:10df9b38dcd44cac8d816645a858237a2021-11-22T04:17:47ZClinical and immunological aspects of microRNAs in neonatal sepsis0753-332210.1016/j.biopha.2021.112444https://doaj.org/article/10df9b38dcd44cac8d816645a858237a2022-01-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0753332221012300https://doaj.org/toc/0753-3322Neonatal sepsis constitutes a highly relevant public health challenge and is the most common cause of infant morbidity and mortality worldwide. Recent studies have demonstrated that during infection epigenetic changes may occur leading to reprogramming of gene expression. Post-transcriptional regulation by short non-coding RNAs (e.g., microRNAs) have recently acquired special relevance because of their role in the regulation of the pathophysiology of sepsis and their potential clinical use as biomarkers. ~22-nucleotide of microRNAs are not only involved in regulating multiple relevant cellular and molecular functions, such as immune cell function and inflammatory response, but have also been proposed as good candidates as biomarkers in sepsis. Nevertheless, establishing clinical practice guidelines based on microRNA patterns as biomarkers for diagnosis and prognosis in neonatal sepsis has yet to be achieved. Given their differential expression across tissues in neonates, the release of specific microRNAs to blood and their expression pattern can differ compared to sepsis in adult patients. Further in-depth research is necessary to fully understand the biological relevance of microRNAs and assess their potential use in clinical settings. This review provides a general overview of microRNAs, their structure, function and biogenesis before exploring their potential clinical interest as diagnostic and prognostic biomarkers of neonatal sepsis. An important part of the review is focused on immune and inflammatory aspects of selected microRNAs that may become biomarkers for clinical use and therapeutic intervention.Ahlam FatmiNafissa ChabniMaría CernadaMáximo VentoMaría González-LópezMourad AribiFederico V. PallardóJosé Luis García-GiménezElsevierarticleMicroRNAsEpigenetic changesImmunityInflammationNeonatal sepsisTherapeutics. PharmacologyRM1-950ENBiomedicine & Pharmacotherapy, Vol 145, Iss , Pp 112444- (2022)
institution	DOAJ
collection	DOAJ
language	EN
topic	MicroRNAs Epigenetic changes Immunity Inflammation Neonatal sepsis Therapeutics. Pharmacology RM1-950
spellingShingle	MicroRNAs Epigenetic changes Immunity Inflammation Neonatal sepsis Therapeutics. Pharmacology RM1-950 Ahlam Fatmi Nafissa Chabni María Cernada Máximo Vento María González-López Mourad Aribi Federico V. Pallardó José Luis García-Giménez Clinical and immunological aspects of microRNAs in neonatal sepsis
description	Neonatal sepsis constitutes a highly relevant public health challenge and is the most common cause of infant morbidity and mortality worldwide. Recent studies have demonstrated that during infection epigenetic changes may occur leading to reprogramming of gene expression. Post-transcriptional regulation by short non-coding RNAs (e.g., microRNAs) have recently acquired special relevance because of their role in the regulation of the pathophysiology of sepsis and their potential clinical use as biomarkers. ~22-nucleotide of microRNAs are not only involved in regulating multiple relevant cellular and molecular functions, such as immune cell function and inflammatory response, but have also been proposed as good candidates as biomarkers in sepsis. Nevertheless, establishing clinical practice guidelines based on microRNA patterns as biomarkers for diagnosis and prognosis in neonatal sepsis has yet to be achieved. Given their differential expression across tissues in neonates, the release of specific microRNAs to blood and their expression pattern can differ compared to sepsis in adult patients. Further in-depth research is necessary to fully understand the biological relevance of microRNAs and assess their potential use in clinical settings. This review provides a general overview of microRNAs, their structure, function and biogenesis before exploring their potential clinical interest as diagnostic and prognostic biomarkers of neonatal sepsis. An important part of the review is focused on immune and inflammatory aspects of selected microRNAs that may become biomarkers for clinical use and therapeutic intervention.
format	article
author	Ahlam Fatmi Nafissa Chabni María Cernada Máximo Vento María González-López Mourad Aribi Federico V. Pallardó José Luis García-Giménez
author_facet	Ahlam Fatmi Nafissa Chabni María Cernada Máximo Vento María González-López Mourad Aribi Federico V. Pallardó José Luis García-Giménez
author_sort	Ahlam Fatmi
title	Clinical and immunological aspects of microRNAs in neonatal sepsis
title_short	Clinical and immunological aspects of microRNAs in neonatal sepsis
title_full	Clinical and immunological aspects of microRNAs in neonatal sepsis
title_fullStr	Clinical and immunological aspects of microRNAs in neonatal sepsis
title_full_unstemmed	Clinical and immunological aspects of microRNAs in neonatal sepsis
title_sort	clinical and immunological aspects of micrornas in neonatal sepsis
publisher	Elsevier
publishDate	2022
url	https://doaj.org/article/10df9b38dcd44cac8d816645a858237a
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Clinical and immunological aspects of microRNAs in neonatal sepsis

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