Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study

Abstract Identification of risk factors for early mortality (EM) in multiple myeloma (MM) patients may contribute to different therapeutic approaches in patients at risk for EM. This population-based study aimed to assess trends in EM and risk factors for EM among MM patients diagnosed in the Nether...

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Autores principales:	Mirian Brink, Kaz Groen, Pieter Sonneveld, Monique C. Minnema, Annemiek Broijl, Avinash G. Dinmohamed, Ellen van der Spek, Mark-David Levin, Paula F. Ypma, Esther de Waal, Eduardus F. M. Ward Posthuma, Sonja Zweegman, Niels W. C. J. van de Donk
Formato:	article
Lenguaje:	EN
Publicado:	Nature Publishing Group 2021
Materias:	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/10e01658db454831b4b2e5e6af5592ee
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spelling	oai:doaj.org-article:10e01658db454831b4b2e5e6af5592ee2021-11-14T12:43:29ZDecrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study10.1038/s41408-021-00571-82044-5385https://doaj.org/article/10e01658db454831b4b2e5e6af5592ee2021-11-01T00:00:00Zhttps://doi.org/10.1038/s41408-021-00571-8https://doaj.org/toc/2044-5385Abstract Identification of risk factors for early mortality (EM) in multiple myeloma (MM) patients may contribute to different therapeutic approaches in patients at risk for EM. This population-based study aimed to assess trends in EM and risk factors for EM among MM patients diagnosed in the Netherlands. All MM patients, newly diagnosed between 1989 and 2018, were identified in the Netherlands Cancer Registry. Patients were categorized into three calendar periods (1989–1998, 1999–2008, 2009–2018) and into five age groups (≤65, 66–70, 71–75, 76–80, >80 years). EM was defined as death by any cause ≤180 days post-diagnosis. We included 28,328 MM patients (median age 70 years; 55% males). EM decreased from 22% for patients diagnosed in 1989–1998 to 13% for patients diagnosed in 2009–2018 (P < 0.01) and this decrease was observed among all age groups. Exact causes of death could not be elucidated. Besides patient’s age, we found that features related to a more aggressive disease presentation, and patient characteristics reflecting patients’ physical condition were predictive of EM. In summary, EM decreased from 1999 onwards. Nevertheless, EM remains high, especially for patients aged >70 years. Therefore, novel strategies should be explored to improve the outcome of patients at risk for EM.Mirian BrinkKaz GroenPieter SonneveldMonique C. MinnemaAnnemiek BroijlAvinash G. DinmohamedEllen van der SpekMark-David LevinPaula F. YpmaEsther de WaalEduardus F. M. Ward PosthumaSonja ZweegmanNiels W. C. J. van de DonkNature Publishing GrouparticleNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENBlood Cancer Journal, Vol 11, Iss 11, Pp 1-7 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Mirian Brink Kaz Groen Pieter Sonneveld Monique C. Minnema Annemiek Broijl Avinash G. Dinmohamed Ellen van der Spek Mark-David Levin Paula F. Ypma Esther de Waal Eduardus F. M. Ward Posthuma Sonja Zweegman Niels W. C. J. van de Donk Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study
description	Abstract Identification of risk factors for early mortality (EM) in multiple myeloma (MM) patients may contribute to different therapeutic approaches in patients at risk for EM. This population-based study aimed to assess trends in EM and risk factors for EM among MM patients diagnosed in the Netherlands. All MM patients, newly diagnosed between 1989 and 2018, were identified in the Netherlands Cancer Registry. Patients were categorized into three calendar periods (1989–1998, 1999–2008, 2009–2018) and into five age groups (≤65, 66–70, 71–75, 76–80, >80 years). EM was defined as death by any cause ≤180 days post-diagnosis. We included 28,328 MM patients (median age 70 years; 55% males). EM decreased from 22% for patients diagnosed in 1989–1998 to 13% for patients diagnosed in 2009–2018 (P < 0.01) and this decrease was observed among all age groups. Exact causes of death could not be elucidated. Besides patient’s age, we found that features related to a more aggressive disease presentation, and patient characteristics reflecting patients’ physical condition were predictive of EM. In summary, EM decreased from 1999 onwards. Nevertheless, EM remains high, especially for patients aged >70 years. Therefore, novel strategies should be explored to improve the outcome of patients at risk for EM.
format	article
author	Mirian Brink Kaz Groen Pieter Sonneveld Monique C. Minnema Annemiek Broijl Avinash G. Dinmohamed Ellen van der Spek Mark-David Levin Paula F. Ypma Esther de Waal Eduardus F. M. Ward Posthuma Sonja Zweegman Niels W. C. J. van de Donk
author_facet	Mirian Brink Kaz Groen Pieter Sonneveld Monique C. Minnema Annemiek Broijl Avinash G. Dinmohamed Ellen van der Spek Mark-David Levin Paula F. Ypma Esther de Waal Eduardus F. M. Ward Posthuma Sonja Zweegman Niels W. C. J. van de Donk
author_sort	Mirian Brink
title	Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study
title_short	Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study
title_full	Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study
title_fullStr	Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study
title_full_unstemmed	Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study
title_sort	decrease in early mortality for newly diagnosed multiple myeloma patients in the netherlands: a population-based study
publisher	Nature Publishing Group
publishDate	2021
url	https://doaj.org/article/10e01658db454831b4b2e5e6af5592ee
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Decrease in early mortality for newly diagnosed multiple myeloma patients in the Netherlands: a population-based study

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