Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy

Abstract Alum is the only licensed adjuvant by Food and Drug Administration of USA used in many human vaccines and has excellent safety record in clinical applications. However, alum hardly induces T helper 1 (Th1) immune responses that are required for anti-tumor immunity. In the present study, we...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Xia Li, Mohamed A. Shenashen, Xiupeng Wang, Atsuo Ito, Akiyoshi Taniguchi, Sherif A. EI-Safty
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/10e091724c084d9a90a00602b8c662f6
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:10e091724c084d9a90a00602b8c662f6
record_format	dspace
spelling	oai:doaj.org-article:10e091724c084d9a90a00602b8c662f62021-12-02T15:06:17ZHierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy10.1038/s41598-017-12446-92045-2322https://doaj.org/article/10e091724c084d9a90a00602b8c662f62017-12-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-12446-9https://doaj.org/toc/2045-2322Abstract Alum is the only licensed adjuvant by Food and Drug Administration of USA used in many human vaccines and has excellent safety record in clinical applications. However, alum hardly induces T helper 1 (Th1) immune responses that are required for anti-tumor immunity. In the present study, we fabricated hierarchical copper- and zinc- buds dressing γ-AlOOH mesostrands (Cu- and Zn-AMSs) with randomly wrinkled morphology, mesoscale void- or cave-like pockets, high-exposed surface coverage sites, and positive charge streams in saline. We confirmed that Cu- and Zn-AMSs promoted intracellular uptake of model cancer antigen (ovalbumin, OVA) by THP-1-differentiated macrophage-like cells in vitro. Moreover, Cu- and Zn-AMSs enhanced maturation and cytokine release of bone marrow dendritic cells in vitro. In vivo study demonstrated that Cu- and Zn-AMSs markedly induced anti-tumor-immunity and enhanced CD4 + and CD8 + T cell populations in splenocytes of mice. These findings demonstrated that hierarchical copper- and zinc- buds dressing γ-AlOOH mesostrands, which are oriented in randomly wrinkled matrice, are suitable platforms as novel adjuvants for cancer immunotherapy.Xia LiMohamed A. ShenashenXiupeng WangAtsuo ItoAkiyoshi TaniguchiSherif A. EI-SaftyNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xia Li Mohamed A. Shenashen Xiupeng Wang Atsuo Ito Akiyoshi Taniguchi Sherif A. EI-Safty Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy
description	Abstract Alum is the only licensed adjuvant by Food and Drug Administration of USA used in many human vaccines and has excellent safety record in clinical applications. However, alum hardly induces T helper 1 (Th1) immune responses that are required for anti-tumor immunity. In the present study, we fabricated hierarchical copper- and zinc- buds dressing γ-AlOOH mesostrands (Cu- and Zn-AMSs) with randomly wrinkled morphology, mesoscale void- or cave-like pockets, high-exposed surface coverage sites, and positive charge streams in saline. We confirmed that Cu- and Zn-AMSs promoted intracellular uptake of model cancer antigen (ovalbumin, OVA) by THP-1-differentiated macrophage-like cells in vitro. Moreover, Cu- and Zn-AMSs enhanced maturation and cytokine release of bone marrow dendritic cells in vitro. In vivo study demonstrated that Cu- and Zn-AMSs markedly induced anti-tumor-immunity and enhanced CD4 + and CD8 + T cell populations in splenocytes of mice. These findings demonstrated that hierarchical copper- and zinc- buds dressing γ-AlOOH mesostrands, which are oriented in randomly wrinkled matrice, are suitable platforms as novel adjuvants for cancer immunotherapy.
format	article
author	Xia Li Mohamed A. Shenashen Xiupeng Wang Atsuo Ito Akiyoshi Taniguchi Sherif A. EI-Safty
author_facet	Xia Li Mohamed A. Shenashen Xiupeng Wang Atsuo Ito Akiyoshi Taniguchi Sherif A. EI-Safty
author_sort	Xia Li
title	Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy
title_short	Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy
title_full	Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy
title_fullStr	Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy
title_full_unstemmed	Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy
title_sort	hierarchically porous, and cu- and zn-containing γ-alooh mesostrands as adjuvants for cancer immunotherapy
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/10e091724c084d9a90a00602b8c662f6
work_keys_str_mv	AT xiali hierarchicallyporousandcuandzncontaininggaloohmesostrandsasadjuvantsforcancerimmunotherapy AT mohamedashenashen hierarchicallyporousandcuandzncontaininggaloohmesostrandsasadjuvantsforcancerimmunotherapy AT xiupengwang hierarchicallyporousandcuandzncontaininggaloohmesostrandsasadjuvantsforcancerimmunotherapy AT atsuoito hierarchicallyporousandcuandzncontaininggaloohmesostrandsasadjuvantsforcancerimmunotherapy AT akiyoshitaniguchi hierarchicallyporousandcuandzncontaininggaloohmesostrandsasadjuvantsforcancerimmunotherapy AT sherifaeisafty hierarchicallyporousandcuandzncontaininggaloohmesostrandsasadjuvantsforcancerimmunotherapy
_version_	1718388496155017216

Hierarchically porous, and Cu- and Zn-containing γ-AlOOH mesostrands as adjuvants for cancer immunotherapy

Ejemplares similares