Lower vitamin D levels are associated with depression in patients with gout

Qiang Zhou, Yi-chuan Shao, Zheng-qi Gan, Li-shu Fang Department of Endocrinology, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China Background: Depression is commonly observed among patients with gout. Low levels of vitamin D have been associated with depression in...

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Autores principales:	Zhou Q, Shao Y, Gan Z, Fang L
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2019
Materias:	depression vitamin gout Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
Acceso en línea:	https://doaj.org/article/10e1550352ff4a9fa99d4eef13a76b9f
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spelling	oai:doaj.org-article:10e1550352ff4a9fa99d4eef13a76b9f2021-12-02T09:14:55ZLower vitamin D levels are associated with depression in patients with gout1178-2021https://doaj.org/article/10e1550352ff4a9fa99d4eef13a76b9f2019-01-01T00:00:00Zhttps://www.dovepress.com/lower-vitamin-d-levels-are-associated-with-depression-in-patients-with-peer-reviewed-article-NDThttps://doaj.org/toc/1178-2021Qiang Zhou, Yi-chuan Shao, Zheng-qi Gan, Li-shu Fang Department of Endocrinology, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China Background: Depression is commonly observed among patients with gout. Low levels of vitamin D have been associated with depression in non-gout subjects. We examined the association of vitamin D levels with depression in patients with gout. Methods: We conducted a cross-sectional study of 186 gout patients at the Endocrinology Department of First Affiliated Hospital of Jiaxing University. Levels of serum 25-hydroxyvitamin D (25(OH)D) were determined using a competitive protein-binding assay. The 17-item Hamilton Depression Scale was used for screening for depressive symptoms. Diagnosis of depression in gout patients was made in accordance with Diagnostic and Statistical Manual of Mental Disorders, fifth edition criteria for depression. Multivariate analysis was performed using logistic regression models. Results: Thirty-two gout patients (17.2%) were diagnosed as having depression. Patients with depression showed significantly lower 25(OH)D levels as compared to patients without depression (46.4±19.0 vs 57.0±17.3 nmol/L, P<0.001). Significant differences in 25(OH)D quartiles of gout patients were observed between the patients with depression and the patients without depression (P=0.003). In multivariate analyses, serum 25(OH)D levels (≤40.0 nmol/L) were independently associated with depression in patients with gout (OR 3.833, 95% CI 1.406–10.453, P=0.009). Conclusion: Our study demonstrates an important association between serum vitamin D levels and depression in patients with gout. Keywords: depression, vitamin, goutZhou QShao YGan ZFang LDove Medical PressarticledepressionvitamingoutNeurosciences. Biological psychiatry. NeuropsychiatryRC321-571Neurology. Diseases of the nervous systemRC346-429ENNeuropsychiatric Disease and Treatment, Vol Volume 15, Pp 227-231 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	depression vitamin gout Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429
spellingShingle	depression vitamin gout Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571 Neurology. Diseases of the nervous system RC346-429 Zhou Q Shao Y Gan Z Fang L Lower vitamin D levels are associated with depression in patients with gout
description	Qiang Zhou, Yi-chuan Shao, Zheng-qi Gan, Li-shu Fang Department of Endocrinology, First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang Province, China Background: Depression is commonly observed among patients with gout. Low levels of vitamin D have been associated with depression in non-gout subjects. We examined the association of vitamin D levels with depression in patients with gout. Methods: We conducted a cross-sectional study of 186 gout patients at the Endocrinology Department of First Affiliated Hospital of Jiaxing University. Levels of serum 25-hydroxyvitamin D (25(OH)D) were determined using a competitive protein-binding assay. The 17-item Hamilton Depression Scale was used for screening for depressive symptoms. Diagnosis of depression in gout patients was made in accordance with Diagnostic and Statistical Manual of Mental Disorders, fifth edition criteria for depression. Multivariate analysis was performed using logistic regression models. Results: Thirty-two gout patients (17.2%) were diagnosed as having depression. Patients with depression showed significantly lower 25(OH)D levels as compared to patients without depression (46.4±19.0 vs 57.0±17.3 nmol/L, P<0.001). Significant differences in 25(OH)D quartiles of gout patients were observed between the patients with depression and the patients without depression (P=0.003). In multivariate analyses, serum 25(OH)D levels (≤40.0 nmol/L) were independently associated with depression in patients with gout (OR 3.833, 95% CI 1.406–10.453, P=0.009). Conclusion: Our study demonstrates an important association between serum vitamin D levels and depression in patients with gout. Keywords: depression, vitamin, gout
format	article
author	Zhou Q Shao Y Gan Z Fang L
author_facet	Zhou Q Shao Y Gan Z Fang L
author_sort	Zhou Q
title	Lower vitamin D levels are associated with depression in patients with gout
title_short	Lower vitamin D levels are associated with depression in patients with gout
title_full	Lower vitamin D levels are associated with depression in patients with gout
title_fullStr	Lower vitamin D levels are associated with depression in patients with gout
title_full_unstemmed	Lower vitamin D levels are associated with depression in patients with gout
title_sort	lower vitamin d levels are associated with depression in patients with gout
publisher	Dove Medical Press
publishDate	2019
url	https://doaj.org/article/10e1550352ff4a9fa99d4eef13a76b9f
work_keys_str_mv	AT zhouq lowervitamindlevelsareassociatedwithdepressioninpatientswithgout AT shaoy lowervitamindlevelsareassociatedwithdepressioninpatientswithgout AT ganz lowervitamindlevelsareassociatedwithdepressioninpatientswithgout AT fangl lowervitamindlevelsareassociatedwithdepressioninpatientswithgout
_version_	1718398166034808832

Lower vitamin D levels are associated with depression in patients with gout

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